PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Budeprion XL (Generic Bupropion)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Budeprion XL is a medication primarily used to treat depression. Like any medication, it comes with potential risks. Some of the risks associated with taking Budeprion XL include:

  • Suicidal Thoughts or Behavior: Antidepressants, including Budeprion XL, may increase the risk of suicidal thoughts or actions, particularly in children, adolescents, and young adults. Close monitoring by a healthcare provider is necessary, especially when starting or changing the dosage.
  • Serotonin Syndrome: Budeprion XL can increase serotonin levels in the brain. If too much serotonin accumulates, it can lead to a potentially life-threatening condition known as serotonin syndrome. Symptoms include confusion, hallucinations, rapid heart rate, fever, excessive sweating, shivering, trembling, muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea.
  • Allergic Reactions: Some individuals may experience allergic reactions to Budeprion XL, which can manifest as rash, itching, swelling, severe dizziness, or trouble breathing. Immediate medical attention is necessary if any of these symptoms occur.
  • Seizures: Budeprion XL may lower the seizure threshold, increasing the risk of seizures, especially in individuals with a history of seizures or certain medical conditions.
  • Manic Episodes: In individuals with bipolar disorder, Budeprion XL may induce manic episodes or hypomania.
  • Withdrawal Symptoms: Abruptly stopping Budeprion XL can lead to withdrawal symptoms, including flu-like symptoms, dizziness, headache, irritability, insomnia, nightmares, nausea, vomiting, diarrhea, anxiety, and agitation. It’s important to taper off the medication under the supervision of a healthcare professional.
  • Other Side Effects: Common side effects of Budeprion XL include dry mouth, nausea, headache, dizziness, constipation, insomnia, weight loss or gain, and sexual dysfunction.

It’s crucial for individuals considering or currently taking Budeprion XL to discuss potential risks and benefits with their healthcare provider and to report any concerning symptoms promptly.

Why is this medication prescribed?

Budeprion XL is typically prescribed for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and other forms of depression. It belongs to a class of medications known as antidepressants, specifically a type called selective serotonin reuptake inhibitors (SSRIs). Budeprion XL works by increasing the levels of serotonin, a neurotransmitter in the brain that affects mood, which can help alleviate symptoms of depression.

How should this medicine be used?

When using Budeprion XL, it’s essential to follow the prescribing healthcare provider’s instructions carefully. Here’s a general guideline on how Budeprion XL should be used:

  • Dosage: The dosage of Budeprion XL will vary depending on factors such as the individual’s age, medical condition, and response to treatment. It’s typically started at a low dose and gradually increased to achieve the desired therapeutic effect.
  • Administration: Budeprion XL is an extended-release tablet intended for once-daily administration. It should be taken orally, swallowed whole with water, and not crushed, chewed, or broken. Taking it with food may help reduce the risk of stomach upset.
  • Consistency: It’s important to take Budeprion XL consistently at the same time each day to maintain stable blood levels of the medication and maximize its effectiveness.
  • Duration of Treatment: Treatment with Budeprion XL is usually long-term, as prescribed by the healthcare provider. Even if symptoms improve, it’s essential to continue taking the medication as directed to prevent relapse. Suddenly stopping Budeprion XL can lead to withdrawal symptoms, so it’s crucial to consult with a healthcare provider before discontinuing the medication.
  • Monitoring: During treatment with Budeprion XL, regular monitoring by a healthcare provider is necessary to assess the response to treatment, manage any side effects, and adjust the dosage if needed. This may involve periodic follow-up appointments and evaluations.
  • Special Instructions: Individuals should inform their healthcare provider about any other medications, supplements, or herbal products they are taking, as certain substances may interact with Budeprion XL. Additionally, it’s important to avoid alcohol while taking Budeprion XL, as it can worsen side effects and impair judgment.

It’s crucial to strictly adhere to the prescribed dosage and usage instructions for Budeprion XL to ensure safe and effective treatment of depression. Any questions or concerns about its use should be discussed with a healthcare provider.

Other uses for this medicine

Some of these off-label uses may include:

  • Seasonal Affective Disorder (SAD): Budeprion XL may be prescribed to help alleviate symptoms of seasonal affective disorder, a type of depression that occurs at specific times of the year, typically during the winter months when there is less natural sunlight.
  • Smoking Cessation: Budeprion XL has been approved by the FDA as a smoking cessation aid under the brand name Zyban. It works by reducing the urge to smoke and minimizing withdrawal symptoms associated with nicotine dependence.
  • Attention-Deficit/Hyperactivity Disorder (ADHD): In some cases, Budeprion XL may be used off-label to help manage symptoms of ADHD, particularly in adults who have not responded well to other treatments.

What special precautions should I follow?

Special precautions should be observed when using Budeprion XL to ensure safe and effective treatment. Here are some key precautions to keep in mind:

  • Suicidal Thoughts and Behavior: Like other antidepressants, Budeprion XL may increase the risk of suicidal thoughts or actions, particularly in children, adolescents, and young adults. Close monitoring by a healthcare provider is essential, especially when starting treatment or adjusting the dosage.
  • Seizure Risk: Budeprion XL can lower the seizure threshold, increasing the risk of seizures, particularly at higher doses. Individuals with a history of seizures, eating disorders, or certain medical conditions should use Budeprion XL with caution and under close medical supervision.
  • Psychiatric Symptoms: Some individuals may experience agitation, anxiety, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, or other unusual changes in behavior while taking Budeprion XL. These symptoms should be promptly reported to a healthcare provider.
  • Allergic Reactions: Serious allergic reactions to Budeprion XL are rare but possible. Individuals who develop rash, itching, swelling, severe dizziness, or trouble breathing should seek immediate medical attention.
  • Interaction with Other Medications: Budeprion XL may interact with other medications, including monoamine oxidase inhibitors (MAOIs), other antidepressants, antipsychotics, stimulants, and certain medications used to treat heart conditions. It’s important to inform a healthcare provider about all medications, supplements, and herbal products being taken to avoid potential interactions.
  • Pregnancy and Breastfeeding: The safety of Budeprion XL during pregnancy and breastfeeding is not well-established. Healthcare providers should weigh the potential risks and benefits before prescribing Budeprion XL to pregnant or breastfeeding individuals.
  • Liver or Kidney Impairment: Individuals with liver or kidney impairment may require dosage adjustments when taking Budeprion XL. Close monitoring by a healthcare provider is necessary in such cases.

These precautions highlight the importance of consulting with a healthcare provider before using Budeprion XL and following their guidance closely throughout treatment. Any questions or concerns about its use should be discussed with a healthcare professional.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Budeprion XL. However, maintaining a healthy diet and staying hydrated can support overall well-being and may enhance the effectiveness of the medication. Avoid excessive alcohol consumption, as it can worsen side effects and interfere with treatment.

What should I do if I forget a dose?

If you miss a dose of Budeprion XL, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you are unsure about what to do, contact your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent dosing schedule to keep stable blood levels of the medication.

What side effects can this medication cause?

Budeprion XL (bupropion extended-release) can cause a range of side effects, although not everyone experiences them, and their severity can vary from person to person. Common side effects of Budeprion XL may include:

  • Dry mouth: This is a common side effect of many medications, including Budeprion XL. Staying hydrated and chewing sugar-free gum can help alleviate dry mouth.
  • Nausea or vomiting: Some individuals may experience gastrointestinal discomfort, including nausea or vomiting, especially when first starting Budeprion XL. Taking the medication with food can help reduce these symptoms.
  • Headache: Headaches are a relatively common side effect of Budeprion XL. Ensuring proper hydration and managing stress levels may help alleviate headaches.
  • Dizziness or lightheadedness: Budeprion XL can cause dizziness or lightheadedness, particularly when standing up quickly. Taking precautions such as rising slowly from a sitting or lying position can help prevent falls.
  • Insomnia or sleep disturbances: Some individuals may experience difficulty sleeping or changes in sleep patterns while taking Budeprion XL. Taking the medication earlier in the day or practicing good sleep hygiene may help improve sleep quality.
  • Weight loss or loss of appetite: Budeprion XL may lead to weight loss or decreased appetite in some individuals. Monitoring weight and ensuring adequate nutrition are important.
  • Tremors or shaking: Budeprion XL can cause tremors or shaking, particularly in the hands. These symptoms are usually mild and may improve over time.
  • Sweating: Excessive sweating, particularly at night, may occur as a side effect of Budeprion XL. Staying hydrated and wearing breathable clothing can help manage this symptom.
  • Constipation: Some individuals may experience constipation while taking Budeprion XL. Eating a high-fiber diet, staying hydrated, and engaging in regular physical activity can help alleviate constipation.
  • Sexual dysfunction: Budeprion XL may cause sexual side effects, including decreased libido, erectile dysfunction, or difficulty achieving orgasm. These effects may improve with time or may require adjustments to the medication regimen.

It’s important to note that while these are common side effects, there are also less common and more serious side effects associated with Budeprion XL, such as allergic reactions, seizures, and changes in mood or behavior. Any unusual or concerning symptoms should be reported to a healthcare provider promptly for evaluation and management.

What should I know about storage and disposal of this medication?

Storage and disposal of Budeprion XL:


  • Store Budeprion XL at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container, tightly closed, and away from moisture and heat.
  • Avoid storing Budeprion XL in the bathroom or kitchen, where moisture and heat levels can fluctuate.
  • Keep Budeprion XL out of reach of children and pets to prevent accidental ingestion.


  • Dispose of any unused or expired Budeprion XL tablets properly.
  • Do not flush Budeprion XL down the toilet or pour it down the drain, as it can contaminate water sources.
  • Check with your pharmacist or local waste disposal facility for guidance on how to dispose of Budeprion XL safely. Some pharmacies may offer medication take-back programs.
  • If no take-back program is available, mix the unused medication with an unpalatable substance like dirt, cat litter, or used coffee grounds, and place it in a sealed plastic bag before throwing it in the trash. This helps prevent accidental ingestion by animals or children.

In case of emergency/overdose

  • Contact emergency services (such as 911) or the nearest poison control center immediately.
  • Provide information about the medication ingested, including the name (Budeprion XL), strength, and the amount taken.
  • Stay with the individual until medical help arrives and follow any instructions provided by emergency responders or poison control.

What other information should I know?

  • Avoid Alcohol: It’s advisable to avoid or limit alcohol consumption while taking Budeprion XL, as alcohol can increase the risk of side effects and may interfere with the effectiveness of the medication.
  • Regular Monitoring: Regularly attend follow-up appointments with your healthcare provider to monitor your response to treatment, adjust the dosage if needed, and address any concerns or side effects.
  • Patient Education: Be informed about the potential side effects, precautions, and interactions associated with Budeprion XL. Ask your healthcare provider any questions you may have and seek clarification if something is unclear.
  • Medical Alert: Inform healthcare providers, including dentists and emergency responders, that you are taking Budeprion XL, as it may interact with other medications or affect certain medical procedures.

By following these guidelines and staying informed about the proper storage, disposal, and handling of Budeprion XL, you can ensure safe and effective use of the medication.

Copyright © 2023