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BoNT-A (Generic AbobotulinumtoxinA Injection)

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A botulinum toxin injection could cause serious or perhaps fatal difficulty breathing or swallowing to spread from the site of injection. People who experience swallowing problems while taking this medicine may do so for several weeks, necessitate feeding through a feeding tube, or even breathe food or liquids into their lungs. AbotulinumtoxinA injections might cause symptoms to appear right away or up to several weeks later. People of any age receiving treatment for any ailment may experience symptoms, but youngsters receiving treatment for spasticity probably run the largest risk (muscle stiffness and tightness). Inform your doctor if you have or have ever had any breathing or swallowing issues, such as asthma or emphysema, or any conditions that affect your muscles or nerves, such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease; condition in which the nerves that control muscle movement slowly die, resulting in the muscles shrinking and weakening), motor neuropathy (condition in which the muscles weaken over time), or myasthenia grav (condition that causes muscle weakness that may improve with activity). Make a quick call to your doctor if you encounter any of the following signs: body-wide muscle weakness or lack of strength; double or blurred vision; sagging eyelids; difficulty breathing, speaking, or eating; or inability to control urination.

When you start receiving abobotulinumtoxinA injections for treatment and at regular intervals throughout your course of treatment, your doctor will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Why is this medication prescribed?

For the treatment of cervical dystonia symptoms, abobotulinumtoxinA injection is employed (spasmodic torticollis; uncontrollable tightening of the neck muscles that may cause neck pain and abnormal head positions). The temporary smoothing of frown lines is another usage for it (wrinkles between the eyebrows). For the treatment of spasticity (muscle stiffness and tightness) in adults and children 2 years of age and older, abobotulinumtoxinA injection is utilised. Among the group of drugs known as neurotoxins is abbotulinumtoxinA injection. It operates by suppressing the nerve impulses that cause the muscles to contract and contract and move in an unregulated manner.

How should this medicine be used?

A doctor will mix a liquid containing abbotulinumtoxin powder and inject the solution into the afflicted muscles. To treat your disease, your doctor will determine the ideal location to inject the drug. Depending on your condition and the length of time the effects of the treatment remain, you could require more abobotulinumtoxinA injections every 3 to 4 months.

Your doctor will likely start you on a low dose of abobotulinumtoxinA injection for cervical dystonia and gradually increase or decrease it based on how you respond to the drug.

Botulinum toxin cannot be switched out for another brand or variety.

An injection of abbotulinumtoxin may help you manage your disease, but it won’t make it go away. Before you fully benefit from an abobotulinumtoxinA injection if you’re treating cervical dystonia, it can take 2 weeks or longer.

Other uses for this medicine

Abobotulinumtoxin Adults with blepharospasm, an uncontrollable tightening of the eyelid muscles that can result in blinking, squinting, and other aberrant eyelid motions, may also be treated with an injection. The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving abobotulinumtoxinA injection,

  • AbotulinumtoxinA, incobotulinumtoxinA (Xeomin), onabotulinumtoxinA (Botox), prabotulinumtoxinA-xvfs (Jeuveau), rimabotulinumtoxinB (Myobloc), any other drugs, cow’s milk protein, or any of the other substances in abobotulinumtoxinA injection should be disclosed to your doctor and pharmacist For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: a few antibiotics, including amikacin, clindamycin (Cleocin), colistimethate (Coly-Mycin), gentamicin, lincomycin (Lincocin), neomycin, polymyxin, streptomycin, and tobramycin; drugs for allergies, colds, and sleep; and sedatives and muscle relaxants. Additionally, let your doctor know whether you’ve recently had any injections of botulinum toxin-containing products. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all the drugs you are taking, even any not on this list, since many other drugs may also interact with abobotulinumtoxinA.
  • Swelling or other indications of infection in the location where abobotulinumtoxinA will be administered should be reported to your doctor. The drug won’t be injected into an infection by your doctor.
  • Inform your doctor if you’ve ever had eye or face surgery, experienced any side effects from using a botulinum toxin product, or have any of the following conditions: bleeding issues, diabetes, a slow or irregular heartbeat, or changes in how your face looks.
  • Your doctor will evaluate you if you’ll be using abotulinumtoxinA to treat wrinkles to determine whether the drug will likely be effective for you. If you have sagging eyes, difficulty raising your eyebrows, extra skin on your eyelids, severely scarred, thick, or greasy skin, or if your wrinkles cannot be smoothed by spreading them apart with your fingers, abbotulinumtoxinA may not work as intended or may result in other issues.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you get pregnant while having an injection of abobotulinumtoxinA.
  • Inform the surgeon or dentist that you are receiving an injection of abobotulinumtoxinA if you are having surgery, including dental surgery.
  • You should be aware that abobotulinumtoxinA injection can result in muscle weakness or loss of strength throughout the body, as well as blurred vision or drooping eyelids. Do not operate machinery, drive a car, or engage in any other risky activity if you have any of these symptoms.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Abobotulinumtoxin Injection side effects are possible. Since some adverse effects may be connected to (or occur more frequently in) the portion of the body where you received the injection, ask your doctor the side effects you are most likely to suffer. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, bruising, redness, or tenderness where the injection was administered
  • Headache
  • Bone or muscle soreness
  • Dry mouth
  • Pain in the legs or arms
  • Tiredness
  • Nausea
  • Depression
  • Having trouble falling or staying asleep
  • Fever, nasal congestion, sneezing, cough, or sore throat

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Vision alterations
  • Responsiveness to light
  • Decreased blinking or dry eyes
  • Swelling, itchiness, or pain in the eyelids
  • Itching
  • Rash
  • Hives
  • Edoema of the lower legs, ankles, feet, or hands
  • Breathing difficulty
  • Dizziness
  • Fainting
  • Slipping or having coordination issues
  • Urinary blood
  • Seizures

Other negative effects from abbotulinumtoxin injections are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs typically do not show up right away after the injection. Tell your doctor straight away if you received too much abobotulinumtoxinA or if you swallowed the drug. Also let them know if you have any of the following symptoms during the following few weeks:

  • Weakness
  • Having trouble moving any bodily portion
  • Having trouble breathing

What other information should I know?

Keep all of your doctor’s appointments.

Ask your pharmacist any inquiries you may have regarding the injection of abobotulinumtoxinA.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Dysport®
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