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Biphetamine (Generic Dextroamphetamine and Amphetamine)

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Dextroamphetamine and amphetamine used together have a habit-forming potential. Never exceed the dosage, frequency, or duration of treatment recommended by your doctor. If you consume too much dextroamphetamine and amphetamine, you can continue to feel the need to consume huge doses of the drug and might exhibit strange behavioural changes. If you see any of the following symptoms, you should contact your doctor right away. heartbeat that is quick, hammering, or irregular; perspiration; dilated pupils; an unusually ecstatic mood; restlessness; irritability; trouble going asleep or staying asleep; anger; aggression; worry; lack of appetite; loss of coordination, uncontrollable movements of a body part, flushed skin, nausea, stomach ache, or thoughts of injuring or killing oneself or others, as well as any planning or attempts at doing so. Dextroamphetamine and amphetamine abuse can potentially result in major heart issues or abrupt death.

Inform your doctor if you or any members of your family regularly use excessive amounts of alcohol, use street drugs, or abuse prescription pharmaceuticals. Most likely, dextroamphetamine and amphetamine won’t be prescribed to you by your doctor.

Dextroamphetamine and amphetamine should not be stopped abruptly without consulting your doctor, especially if you have abused the drugs. Your dose will likely be gradually reduced by your doctor, who will also closely watch you during this period. If you abruptly cease taking dextroamphetamine and amphetamine after using it excessively, you could experience severe depression and exhaustion.

Avoid sharing, selling, or allowing others to use your medication. Dextroamphetamine and amphetamine are illegal to sell or distribute because they can be harmful to other people. Amphetamine and dextroamphetamine should be kept in a secure location to prevent accidental or intentional consumption by others. Count the remaining tablets or capsules so you can identify any missing ones.

When you start therapy with dextroamphetamine and amphetamine, as well as each time you acquire extra medication, your doctor or pharmacist will give you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Why is this medication prescribed?

Adderall, Adderall XR, and Mydayis, which combine dextroamphetamine and amphetamine, are used as a part of a therapy programme to manage the signs and symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age). ADHD is treated with Adderall in both adults and children older than 3 years old. Adults and children 6 years of age and older who suffer from ADHD are treated with Adderall XR. Adults and children over the age of 13 who suffer from ADHD are treated with Mydayis.  The combination of dextroamphetamine and amphetamine (Adderall) is also used to treat narcolepsy, a sleep disorder that affects people of all ages and involves excessive daytime sleepiness and unexpected sleep attacks. Dextroamphetamine and amphetamine belong to a group of drugs known as central nervous system stimulants. It functions by altering the brain’s natural chemical composition.

How should this medicine be used?

In the form of an immediate-release tablet (Adderall) and an extended-release (long-acting) capsule (Adderall XR, Mydayis), the combination of dextroamphetamine and amphetamine is available for oral consumption. It is typical to take the immediate-release pill (Adderall) 2 to 3 times a day, spaced 4 to 6 hours apart, with or without food. The extended-release pill (Adderall XR) is often taken with or without food as soon as you wake up. Typically taken in the morning with or without food, the extended-release capsule (Mydayis) must be taken consistently. A combination of dextroamphetamine and amphetamine should not be used in the late afternoon or evening since it may make it difficult to fall or remain asleep. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Amphetamine and dextroamphetamine should be taken exactly as prescribed.

Do not chew or shatter the extended-release capsules; instead, swallow them whole. The extended-release capsule’s complete contents can be opened and sprinkled on a teaspoon of applesauce if you are unable to take it. Do not chew this combination; immediately swallow it. Do not divide the contents of a capsule into multiple doses or preserve the combination of applesauce and medication for later use.

Dextroamphetamine and amphetamine will likely be prescribed to you at a low starting dose by your doctor, who will then progressively raise it up to once per week.

Dextroamphetamine and amphetamine may occasionally be prescribed to you by your doctor in order to determine whether you still require the drug. Pay close attention to these guidelines.

You cannot exchange one dextroamphetamine and amphetamine product for another because the drug in each product is absorbed by the body in a different way. Your physician will suggest the optimal dose for you if you are transitioning from one product to another.

Other uses for this medicine

It is not recommended to use dextroamphetamine and amphetamine together to treat extreme fatigue that is not related to narcolepsy.

Ask your doctor or pharmacist for more details if you think you might need this drug for something else.

What special precautions should I follow?

Before taking dextroamphetamine and amphetamine,

  • Inform your doctor and pharmacist about any allergies you may have to dextroamphetamine, amphetamine, other stimulant drugs including benzphetamine, lisdexamfetamine (Vyvanse), or methamphetamine (Desoxyn), other drugs, or any of the chemicals in dextroamphetamine and amphetamine preparations. For a list of the ingredients, ask your pharmacist.
  • Inform your physician if you are currently taking any of the following drugs or have stopped taking them within the previous 14 days: monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Dextroamphetamine and amphetamine should be stopped, and then at least 14 days should pass before starting an MAO inhibitor.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and herbal supplements you are taking. Incorporate any of the following: Acetazolamide (Diamox); alpha blockers like tamsulosin (Flomax, in Jalyn), alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), and terazosin; antidepressants (also known as “mood elevators”), antihistamines (medications for colds and allergies), ascorbic acid (Vitamin C), and other antacids and medications for heartburn or ulcers like cimetidine (Tagamet), esomeprazole (Nexium), omeprazole (Prilosec, in Zegerid), and pantoprazole (Protonix); beta blockers like buspirone, chlorpromazine, fentanyl (Actiq, Duragesic, Subsys, and others); guanethidine (no longer available in the United States); lithium (Lithobid); meperidine (Demerol); and methenamine (Hiprex, Urex); beta blockers like atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL); drugs for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); quinidine (in Nuedexta); reserpine; ritonavir (Norvir, in Kaletra); serotonin and norepinephrine reuptake inhibitors like desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); selective serotonin-reuptake inhibitors like citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem,in Symbyax), tramadol (Conzip, in Ultracet), sodium phosphate, sodium bicarbonate (Arm and Hammer Baking Soda, Soda Mint), some thiazide diuretics (‘water pills,’ tramadol), or tricyclic antidepressants (‘mood lifters,’ such as desipramine (Norpramin), or protriptyline (Vivactil). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician about any nutritional supplements you are taking, notably glutamic acid and St. John’s wort (L-glutamine).
  • Inform your doctor if you experience any symptoms of glaucoma (increased eye pressure that can result in vision loss), hyperthyroidism (condition marked by an excess of thyroid hormone in the body), or feelings of anxiety, tension, or agitation. Dextroamphetamine and amphetamine should not be taken, according to your doctor.
  • Inform your doctor if anyone in your family has ever experienced a sudden death or has an abnormal heartbeat. Additionally, let your doctor know if you have or have had had a heart defect, high blood pressure, an irregular heartbeat, artery hardening, heart illness, blood vessel disease, or any other cardiac issues. Your heart and blood vessels will be checked by your doctor during the examination. If you have a heart issue or there is a strong likelihood that you will develop a heart condition, your doctor will likely advise you not to use dextroamphetamine and amphetamine.
  • Inform your doctor if you or anyone in your family has ever experienced depression, bipolar disorder (a condition characterised by mood swings between depressed and abnormally excited), mania, motor tics, verbal tics, or Tourette’s syndrome (a condition characterised by the need to perform repetitive motions or to repeat sounds or words), or if you have ever considered or tried suicide. Tell your doctor if you have or have ever had liver or kidney disease, seizures, liver or kidney disease, mental illness, or an abnormal electroencephalogram (EEG).
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking dextroamphetamine and amphetamine. While taking dextroamphetamine and amphetamine, avoid breastfeeding.
  • If you are 65 years of age or older, discuss the advantages and disadvantages of taking dextroamphetamine and amphetamine with your doctor. Dextroamphetamine and amphetamine are often not recommended for usage in older persons since they are less safe than alternative treatments for the same disease.
  • You should be aware that taking this medication may make it challenging for you to carry out activities that call for mental alertness or physical coordination. Until you are certain of how this drug will affect you, avoid using machinery or driving a car.
  • You should be aware that amphetamine and dextroamphetamine should be administered as a part of an all-encompassing treatment plan for ADHD, which may also involve counselling and special education. Follow all the advice given to you by your physician and/or therapist.
  • You should be aware that dextroamphetamine and amphetamine, particularly in children and teenagers with significant heart conditions or heart abnormalities, can result in rapid death. Adults taking this medication, particularly those with major cardiac issues or heart deformities, run the risk of experiencing sudden death, heart attacks, or stroke. If you or your child has any symptoms of heart problems while taking this drug, such as chest discomfort, breathlessness, or fainting, contact your doctor straight away and seek emergency care.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you forget to take your morning dose of the extended-release capsule, skip it and take your next dose at the scheduled time the following day. Do not take another dose at a later time. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Amphetamine and dextroamphetamine may have negative side effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nervousness
  • Headache
  • Modifications to sex desire or capacity
  • Menstrual cramps that hurt
  • Mouth ache
  • Constipation
  • Diarrhea
  • Nausea
  • Slim down

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you encounter any of the symptoms below or those in the IMPORTANT WARNING section:

  • Slow or challenging speech
  • Dizziness
  • An arm or leg that is weak or numb
  • Seizures
  • Verbal or motor tics
  • Tooth gnashing
  • Depression
  • Assuming falsehoods to be true
  • Feeling unusually wary about other people
  • Hallucinating (seeing objects or hearing sounds that do not exist)
  • Agitation, hallucinations (hearing voices or seeing things that are not there), disorientation, fever, sweating, shivering, extremely stiff or twitching muscles, loss of coordination, nausea, vomiting, or diarrhoea
  • Mania (frenzied or too exuberant mood) (frenzied or overly exuberant emotion)
  • Eyesight alterations or blurry vision
  • The fingers or toes are pale or have a bluish tint.
  • Tingling, burning, numbness, or pain in the hands or feet
  • Unidentified cuts on the fingers or toes
  • Skin that is swollen or peeling
  • Rash
  • Hives
  • Itching
  • Swelling of the tongue, throat, eyes, or face
  • Breathing or swallowing challenges
  • Hoarseness

Children and teenagers who have heart abnormalities or major cardiac conditions are especially vulnerable to sudden mortality from dextroamphetamine and amphetamine use. Adults taking this medicine, particularly those with major cardiac conditions or heart abnormalities, are at risk for sudden death, heart attacks, and stroke. If you or your child has chest pain, breathlessness, or fainting while taking this medication, contact your doctor straight away. The dangers of using this drug should be discussed with your doctor.

Children’s growth and weight gain may be slowed by dextroamphetamine and amphetamine use. The physician for your child will keep a close eye on their development. If you are worried about your child’s weight gain or growth while taking this medicine, talk to your child’s doctor. The hazards of providing dextroamphetamine and amphetamine to your child should be discussed with their doctor.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at ambient temperature and shield it from light, too much heat, and moisture (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

The following are examples of overdose symptoms:

  • Restlessness
  • Confusion
  • Violent conduct
  • Panic-like emotions
  • hallucination (seeing things or hearing voices that do not exist)
  • Rapid respiration
  • Body part shaking that is uncontrollable
  • Fever
  • Pee with cola or dark red colouring
  • Muscular ache or weakness
  • Weakness or exhaustion
  • Depression
  • Rapid or erratic heartbeat
  • Fainting
  • Dizziness
  • Fuzzy vision
  • Stomach pain
  • Vomiting
  • Diarrhea
  • Seizures
  • Coma (loss of consciousness for a period of time)

What other information should I know?

Keep all of your appointments with the lab and your doctor. To determine how dextroamphetamine and amphetamine affect your body, your doctor may request specific lab tests.

Inform the lab staff and your doctor that you are taking dextroamphetamine and amphetamine prior to any laboratory test.

This medication cannot be renewed. In order to prevent running out of medication, make sure you plan regular doctor’s appointments.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Mydayis® (as a combination product containing Amphetamine, Dextroamphetamine)
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