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Bevacizumab Injection

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Why is this medication prescribed?

Bevacizumab injection products are used

  • In addition to other chemotherapy drugs to treat rectum or colon cancer that has metastasized to other areas of the body;
  • ln conjunction with other chemotherapy drugs to treat specific forms of lung cancer that cannot be surgically removed due to their metastasis to neighbouring tissues or other body parts, or that have reappeared after receiving other chemotherapy drugs;
  • To treat glioblastoma (a specific kind of malignant brain tumour), which has not improved or returned after being treated with various drugs;
  • To treat renal cell cancer (RCC), a kind of cancer that starts in the kidney and has progressed to other organs, in conjunction with interferon alfa;
  • To treat cervical cancer (cancer that starts in the womb’s entrance) that has not improved, returned after treatment with other drugs, or spread to other parts of the body; in conjunction with other chemotherapy drugs;
  • In addition to other chemotherapy drugs to treat specific kinds of ovarian cancer (female reproductive organs where eggs are produced), fallopian tube cancer (tube that transports eggs released from the ovaries to the uterus), and peritoneal cancer (tissue lining the abdomen) that have not improved or have returned after being treated with other drugs; and

Hepatocellular carcinoma (HCC) that has spread or cannot be removed surgically is treated with bevacizumab injection (Avastin) and atezolizumab in patients who have not previously taken chemotherapy.

Antiangiogenic agents are a class of drugs that includes bevacizumab injectable products. They function by preventing the growth of blood vessels, which supply oxygen and nutrition to tumours. This might inhibit the development and spread of malignancies.

How should this medicine be used?

Products for injecting bevacizumab are available as liquid solutions that need to be injected slowly into a vein. A physician or nurse will administer bevacizumab injectable products in a clinic, infusion facility, or hospital. Injections of bevacizumab are typically administered once every two or three weeks. Your dose regimen will be determined by your condition, the medications you are currently taking, and how well your body responds to therapy.

You will get your first dose of a bevacizumab injectable product 90 minutes later. To monitor how your body responds to bevacizumab, a doctor or nurse will keep a careful eye on you. It typically takes 30 to 60 minutes for you to receive each of the subsequent doses of the drug if you do not experience any major issues when you receive your first dosage of a bevacizumab injection product.

When the medication is infused, bevacizumab injectable products have the potential to produce significant side effects. Tell your doctor right away if you have any of the following symptoms: shortness of breath, chills, shivering, sweating, headaches, chest discomfort, dizziness, feeling faint, flushing, itching, rash, or hives. If you develop these or other side effects, your doctor may need to reduce the rate of your infusion or postpone or discontinue your treatment.

Other uses for this medicine

Wet age-related macular degeneration is another condition that can be treated with bevacizumab injection (Avastin) (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). Discuss the dangers of using bevacizumab to treat your disease with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving a bevacizumab injection product,

  • If you have an allergy to bevacizumab, bevacizumab-awwb, bevacizumab-bvzr, any other drugs, or any of the ingredients in bevacizumab injection products, notify your doctor and pharmacist right away.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention whether you are now taking or have ever taken an anthracycline, which is a class of chemotherapy used to treat breast cancer and some forms of leukaemia. Examples include daunorubicin (Cerubidine), doxorubicin, epirubicin (Ellence), and idarubicin (Idamycin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had diabetes, high blood pressure, heart failure, or any other condition that affects your heart or blood vessels, as well as if you have ever received radiation therapy to the left side of your chest or pelvis (tubes that move blood between the heart and other parts of the body). Notify your physician if you have recently coughed up blood as well.
  • You should be aware that bevacizumab injectable products can lead to infertility in women (difficulty getting pregnant), but you shouldn’t automatically think that you couldn’t. Inform your doctor if you are expecting a child or if you intend to do so. Throughout your bevacizumab injection treatment and for at least six months following your last dose, you should take birth control to avoid getting pregnant. Call your doctor right away if you get pregnant while taking a bevacizumab injection. Bevacizumab may be harmful to the foetus and raise the possibility of miscarriage.
  • Describe to your doctor if you are nursing a baby. While receiving treatment with a bevacizumab injection product and for at least six months following your last dose, you shouldn’t breastfeed.
  • You ought to be aware that this medicine can result in ovarian failure. Consult your doctor on the possibility of bevacizumab-related female infertility.
  • If you plan to have surgery, including dental surgery, or if you have previously had surgery, let your doctor know. Your doctor will cease your bevacizumab injectable treatment at least 28 days before the surgery if you are going to have it. You shouldn’t receive a bevacizumab injection product if you recently had surgery until at least 28 days have elapsed and the area has fully recovered.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor as soon as you can if you are unable to keep a scheduled appointment to receive a dosage of a bevacizumab injectable product.

What side effects can this medication cause?

There may be negative effects with bevacizumab injectable products. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Dizziness
  • Reduced appetite
  • Heartburn
  • Alterations in food taste
  • Diarrhoea
  • Slim down
  • Sores in the mouth or on the skin
  • Voice variations
  • Either more or fewer tears
  • Runny or congested nose
  • Joint or muscle ache
  • Difficulty sleeping

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Bleeding from the gums or from the nostrils, bloody or coffee-ground-looking vomit or coughing, or unusual bruising or bleeding; vaginal or menstrual bleeding that is more frequent; Crimson or tarry black stools, pink, red, or dark brown urine, headache, dizziness, or weakness
  • Having trouble swallowing
  • Slow or challenging speech
  • Faintness
  • Arm or leg that is weak or numb
  • Chest ache
  • Arm, neck, jaw, stomach, or upper back pain
  • Wheeze or breathing difficulties
  • Seizures
  • Extreme fatigue
  • Confusion
  • Loss of eyesight or a change in vision
  • Fever, chills, and other symptoms of illness in addition to a painful throat
  • Edoema of the lower legs, lower arms, hands, feet, ankles, or stomach
  • Unjustified weight gain
  • Urinary foam
  • Only experiencing pain, soreness, warmth, redness, or swelling in one leg.
  • Skin that is irritated, itchy, or flaky
  • Abdominal discomfort, diarrhoea, nausea, vomiting, chills, or fever

Other negative effects could be brought on by bevacizumab injectable products. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments. Throughout your use of a bevacizumab injectable product, your doctor will routinely monitor your blood pressure and perform a urine test.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Alymsys® (bevacizumab-maly)
  • Avastin® (bevacizumab)
  • Mvasi® (bevacizumab-awwb)
  • Zirabev® (bevacizumab-bvzr)
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