WARNING

Besremi is a medication used to treat anemia caused by myelodysplastic syndromes, a group of disorders where the bone marrow doesn’t produce enough healthy blood cells. Like any medication, it carries certain risks. Here are some of them:

• Bone Marrow Suppression: Besremi can suppress bone marrow function, leading to decreased production of red blood cells, white blood cells, and platelets. This can increase the risk of infections, bleeding, and fatigue.
• Risk of Infections: Since Besremi can decrease white blood cell count, it may increase susceptibility to infections. Patients should be monitored for signs of infection and seek medical attention if any occur.
• Risk of Bleeding: Reduced platelet count can lead to an increased risk of bleeding. Patients may experience bruising, nosebleeds, or bleeding gums.
• Hypersensitivity Reactions: Some patients may experience allergic reactions to Besremi, which can range from mild to severe. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing.
• Liver Toxicity: Besremi can cause liver toxicity, leading to abnormal liver function tests. Patients with pre-existing liver conditions may be at higher risk.
• Fluid Retention: Besremi may cause fluid retention, leading to swelling in the legs, ankles, or other parts of the body. This can exacerbate conditions such as heart failure.
• Embryo-Fetal Toxicity: Besremi can harm unborn babies if taken during pregnancy. Women of childbearing age should use effective contraception while on Besremi.

These risks highlight the importance of careful monitoring by healthcare professionals when using Besremi and the need for patients to report any concerning symptoms promptly. Always consult with a healthcare provider for personalized medical advice and monitoring when taking Besremi or any other medication.

Why is this medication prescribed?

Besremi (ropeginterferon alfa-2b-njft) is prescribed for the treatment of anemia caused by myelodysplastic syndromes (MDS) in adults. Myelodysplastic syndromes are a group of disorders characterized by ineffective production of blood cells in the bone marrow, leading to low levels of red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). Besremi works by stimulating the bone marrow to produce more red blood cells, thereby alleviating anemia in patients with MDS.

How should this medicine be used?

Besremi (ropeginterferon alfa-2b-njft) is a medication used to treat anemia caused by myelodysplastic syndromes (MDS) in adults. Here’s how Besremi should be used:

• Dosage and Administration: The dosage of Besremi and the frequency of administration will be determined by a healthcare professional based on individual patient factors, including the severity of anemia and other medical conditions. Typically, Besremi is administered subcutaneously (under the skin) once every two weeks.
• Injection Technique: Besremi is supplied as a solution in a prefilled syringe or autoinjector. Before administering the injection, the patient or caregiver should carefully read the instructions provided by the healthcare provider or the medication’s packaging. The injection site should be rotated to avoid irritation or tissue damage.
• Preparation: Before administering the injection, the patient or caregiver should inspect the solution for any particulate matter or discoloration. If any abnormalities are observed, the medication should not be used.
• Storage: Besremi should be stored according to the manufacturer’s instructions, typically at room temperature away from light and moisture. It should not be frozen.
• Monitoring: During treatment with Besremi, patients will typically undergo regular monitoring of their blood counts and liver function tests to assess the medication’s effectiveness and detect any adverse effects. Healthcare providers may adjust the dosage based on these monitoring results.
• Adherence: It’s essential for patients to adhere to the prescribed dosage and administration schedule for Besremi to achieve the best possible outcomes. Missing doses or altering the dosage without consulting a healthcare provider can affect the medication’s effectiveness and safety.
• Follow-Up: Patients should follow up with their healthcare provider regularly to monitor their response to Besremi and discuss any concerns or side effects they may experience during treatment.

As with any medication, it’s crucial for patients to communicate openly with their healthcare provider about their treatment experience and to seek guidance if they have any questions or concerns about using Besremi.

Other uses for this medicine

Besremi (ropeginterferon alfa-2b-njft) is primarily indicated for the treatment of anemia due to myelodysplastic syndromes (MDS) in adults. Its use for other conditions is not established and should only be prescribed by healthcare professionals based on careful evaluation of individual patient needs and risks.

What special precautions should I follow?

Special precautions should be followed when using Besremi. Here are some important considerations:

• Medical History: Before starting Besremi, inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or previous treatments for MDS.
• Pregnancy and Breastfeeding: Besremi may cause harm to unborn babies if used during pregnancy. Women of childbearing age should use effective contraception during treatment with Besremi and for a period of time after discontinuation, as recommended by their healthcare provider. It is not known whether Besremi passes into breast milk, so breastfeeding while using Besremi is not recommended.
• Liver Function: Besremi may cause liver toxicity, so regular monitoring of liver function tests is usually recommended during treatment. Patients with pre-existing liver conditions may be at higher risk of adverse effects and should be closely monitored.
• Hypersensitivity Reactions: Some patients may experience allergic reactions to Besremi. Inform your healthcare provider immediately if you experience symptoms such as rash, itching, swelling, dizziness, or difficulty breathing.
• Infections: Besremi can suppress the immune system, increasing the risk of infections. Report any signs of infection, such as fever, sore throat, or cough, to your healthcare provider promptly.
• Bleeding Risk: Besremi may decrease platelet counts, increasing the risk of bleeding. Be cautious to avoid injuries, and report any signs of bleeding, such as easy bruising or bleeding gums, to your healthcare provider.
• Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Besremi.
• Storage: Store Besremi as directed by the manufacturer, and do not use it if it has been frozen or if there are any signs of contamination.
• Follow-Up: Attend all scheduled appointments with your healthcare provider for monitoring of your condition and response to treatment.

Always follow your healthcare provider’s instructions and consult them with any questions or concerns regarding the use of Besremi.

What special dietary instructions should I follow?

Regarding special dietary instructions for Besremi, there are no specific dietary restrictions associated with this medication. However, maintaining a healthy and balanced diet can support overall well-being and may help manage symptoms of myelodysplastic syndromes.

What should I do if I forget a dose?

If you forget a dose of Besremi, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Besremi (ropeginterferon alfa-2b-njft) may cause side effects in some individuals. Common side effects may include:

• Injection Site Reactions: Pain, redness, swelling, or itching at the injection site are common reactions.
• Flu-like Symptoms: Fever, chills, fatigue, muscle aches, and headache may occur, especially at the beginning of treatment. These symptoms typically improve over time.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting as side effects of Besremi.
• Fatigue: Feeling tired or weak is a common side effect of Besremi.
• Decreased Appetite: Some people may experience a loss of appetite while taking Besremi.
• Muscle and Joint Pain: Pain or discomfort in the muscles or joints may occur as a side effect.
• Dizziness or Lightheadedness: Feeling dizzy or lightheaded is a possible side effect of Besremi.
• Hair Loss: Some individuals may experience hair thinning or hair loss while taking Besremi.
• Changes in Liver Function: Besremi may affect liver function, leading to changes in liver enzyme levels. Your healthcare provider may monitor your liver function with blood tests during treatment.
• Blood Cell Changes: Besremi may affect the production of blood cells, leading to changes in red blood cell, white blood cell, or platelet counts. Regular blood tests may be needed to monitor these changes.
• Hypersensitivity Reactions: In rare cases, individuals may experience allergic reactions to Besremi, which can range from mild to severe. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. If you experience any concerning symptoms or side effects while taking Besremi, it’s essential to inform your healthcare provider promptly. They can provide guidance on managing side effects and determine if any adjustments to your treatment are needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Besremi:

• Storage:
  • Store Besremi as directed by the manufacturer, typically at room temperature away from light and moisture.
  • Do not freeze Besremi.
  • Keep Besremi out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired Besremi in accordance with local regulations or as instructed by your healthcare provider or pharmacist.
  • Do not dispose of Besremi in household trash unless specifically instructed to do so.

In case of emergency/overdose

• In case of an emergency or overdose, seek immediate medical attention or contact a poison control center.
• If possible, provide the healthcare provider with information about the amount of Besremi ingested and any symptoms experienced.

What other information should I know?

• Keep all appointments with your healthcare provider for monitoring of your condition and response to treatment with Besremi.
• Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Besremi.
• Do not change your dose or stop taking Besremi without consulting your healthcare provider.
• Follow your healthcare provider’s instructions regarding dietary restrictions, if any, while taking Besremi.
• Report any new or worsening symptoms to your healthcare provider promptly.
• Keep a list of all your medications and share it with your healthcare provider and pharmacist.

By following these guidelines for storage, disposal, emergency procedures, and other important information, you can ensure the safe and effective use of Besremi as prescribed by your healthcare provider. If you have any questions or concerns about Besremi, don’t hesitate to discuss them with your healthcare provider or pharmacist.