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Benadryl (Generic Diphenhydramine Injection)

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Why is this medication prescribed?

For those who cannot take diphenhydramine orally, diphenhydramine injection is a common treatment for allergic responses. As a motion sickness remedy, it is also employed. For the treatment of Parkinson’s syndrome, diphenhydramine injection is also utilised, either by itself or in combination with other drugs (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Premature or newborn infants shouldn’t receive a diphenhydramine injection. A group of drugs known as antihistamines includes diphenhydramine injection. Histamine, a chemical in the body that triggers allergic reactions, is blocked in order for it to function.

How should this medicine be used?

Diphenhydramine injection is available as a solution (liquid) that can be administered intravenously or intramuscularly (into a vein). Your illness and how you react to treatment will determine your dose regimen.

You can either deliver diphenhydramine injection in a hospital setting or at home. Your doctor will demonstrate how to administer diphenhydramine injection if you plan to do so at home. Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using diphenhydramine injection,

  • If you have any allergies, including those to any other drugs, diphenhydramine, other antihistamines, including dimenhydrinate (Dramamine), or any of the substances in diphenhydramine injection, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Include the following: muscle relaxants, sedatives, sleeping aids, and tranquillizers; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).
  • If you are breastfeeding, let your doctor know. Given the possibility of danger to nursing infants, your doctor will likely advise against using diphenhydramine injection if you are doing so.
  • Inform your doctor if you have or have ever had any of the following conditions: ulcers; prostatic hypertrophy (enlargement of the prostate gland) or difficulty urinating (due to an enlarged prostate gland); asthma; other types of lung disease; glaucoma; high blood pressure; or hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormone).
  • If you are pregnant or plan to become pregnant, let your doctor know. Call your doctor if you get pregnant while using diphenhydramine injection.
  • Diphenhydramine injection may cause drowsiness, therefore you should be aware of it. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • Consult your doctor about whether drinking alcohol is safe while taking diphenhydramine injection. Diphenhydramine injection adverse effects may get severe if alcohol is consumed.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The injection of diphenhydramine could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Dizziness
  • Tiredness
  • Confusion
  • Restlessness
  • Enthusiasm (especially in children)
  • Nervousness
  • Irritability
  • Having trouble falling or staying asleep
  • Vision alterations
  • Digestive discomfort
  • Nausea
  • Vomiting
  • Constipation
  • Having trouble urinating
  • Alteration in urination frequency
  • Hearing ringing
  • Yhroat, nose, or mouth aridity
  • Difficulty coordinating
  • Body part shaking that is uncontrollable

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Rash
  • Hives
  • Chills
  • Chest constriction
  • Wheezing
  • Seizures

Other negative effects from diphenhydramine injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from light, excessive heat, and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Mouth ache
  • Digestive discomfort
  • Dilated eyes (black circles in the centres of the eyes)
  • Flushing
  • Hallucinations (seeing objects or hearing voices that do not exist)
  • Seizures

What other information should I know?

Ask your pharmacist any inquiries you may have regarding the injection of diphenhydramine.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Benadryl
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