PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!


Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Belzutifan should not be taken if you are expecting, want to get pregnant, or want to father a child. Before beginning treatment, you must take a pregnancy test. You must take non-hormonal birth control while receiving treatment and for a week following your last dose if you are a female. You shouldn’t use hormonal contraceptives (birth control pills, patches, rings, implants, or injections) as your sole method of birth control while receiving therapy for belzutifan since they may interfere with their effectiveness. If you’re a man, you and your female partner should both use birth control while you’re receiving therapy and for one week following your last dose. Ask your doctor to assist you in selecting a birth control technique that is effective for you or your partner. The foetus could be harmed by belzutifan.

Whenever you need a prescription refill for belzutifan, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (

Why is this medication prescribed?

Belzutifan is used to treat some types of pancreatic cancer in individuals with von Hippel-Lindau syndrome that don’t require immediate surgery, as well as renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas (tumours in the brain and spinal cord), and renal cell carcinoma (RCC) (VHL; a rare disease that causes tumours and cysts). Belzutifan is a member of a class of medications called inhibitors of the hypoxia-inducible factor. It works by blocking the action of a particular protein in people with VHL.

How should this medicine be used?

Belzutifan is available as an oral tablet. The normal dosage is one dose per day, with or without food. Belzutifan should be taken every day at around the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Belzutifan should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not chew, break, or crush the tablets; instead, swallow them whole.

Do not take another dose of belzutifan if you vomit after taking it. The following day, carry on with your typical dosage routine.

If you suffer certain adverse effects, your doctor may decide to temporarily or permanently stop your therapy or lower your dose. During the course of your belzutifan therapy, be sure to let your doctor know how you are feeling. Belzutifan should be taken even if you feel fine. Belzutifan should not be stopped without first consulting your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking belzutifan,

  • If you have any allergies, including to belzutifan, other drugs, or any of the substances in belzutifan tablets, notify your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention the drugs imatinib (Gleevec), fentanyl (Duragesic), fluvoxamine (Luvox), midazolam, and ticlopidine that are listed in the IMPORTANT WARNING section. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Belzutifan may interact with a wide variety of other drugs, so be sure to let your doctor know about everything you’re taking, even anything not on this list.
  • If you have anaemia now or ever had, let your doctor know (a lower than normal number of red blood cells).
  • If you are breastfeeding, let your doctor know. While using belzutifan and for one week following your last dose, you shouldn’t breastfeed.
  • You should be aware that both men and women who use this medicine may have decreased fertility. The dangers of taking belzutifan should be discussed with your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Continue with your regular dosing plan the following day after taking the missing dose as soon as you remember it that day. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Belzutifan could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Dizziness
  • Tiredness
  • Headache
  • Nausea
  • Constipation
  • Abdominal pain
  • Muscular or joint ache
  • Vision alterations
  • Gaining weight
  • Infection-related symptoms such as fever, coughing, and shortness of breath

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Fatigue, a cold sensation, pale skin, a cough or chest pain, or a rapid heartbeat

Other negative effects of belzutifan are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom). To keep the tablets dry, store the two desiccant (drying agent) canisters in the prescription bottle. The desiccant canisters shouldn’t be eaten.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include:

  • Skin, nails, and lips are bluish in tone.
  • Breathing difficulty or a rapid heartbeat

What other information should I know?

Keep all of your appointments with your physician and the lab. Before and during your treatment, your doctor will order certain lab tests to monitor your body’s reaction to belzutifan.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Welireg®
Copyright © 2023