PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!


Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Belumosudil is a medication primarily prescribed to treat chronic graft-versus-host disease (cGVHD) in adults and pediatric patients aged 12 years and older who have previously received at least two prior lines of systemic therapy. cGVHD is a complication that can occur after a stem cell or bone marrow transplant where the donor’s immune cells attack the recipient’s tissues and organs.

Belumosudil works by inhibiting a specific enzyme called Rho-associated coiled-coil kinase 2 (ROCK2), which plays a role in immune cell activation and migration. By inhibiting ROCK2, Belumosudil helps to reduce inflammation and suppress the immune response, thereby alleviating the symptoms of cGVHD.

How should this medicine be used?

As for how to use Belumosudil, it is typically administered orally as a tablet. The dosage and frequency of administration will depend on various factors such as the patient’s age, weight, overall health, and the severity of their condition. It’s essential to follow the dosage instructions provided by the healthcare provider or as indicated on the prescription label.

Usually, Belumosudil is taken with or without food. However, it’s crucial to follow your healthcare provider’s specific instructions regarding how to take the medication. It’s essential not to crush, chew, or break the tablets but to swallow them whole with a glass of water.

Additionally, it’s essential to take Belumosudil regularly and consistently as prescribed by your healthcare provider to achieve the best results. Missing doses or stopping the medication abruptly can affect its effectiveness and may worsen your condition.

Before starting Belumosudil, it’s essential to inform your healthcare provider about any other medications, supplements, or herbal remedies you are currently taking to avoid potential interactions. Also, discuss any existing medical conditions or allergies you have to ensure Belumosudil is safe and suitable for you. Always consult your healthcare provider if you have any questions or concerns about your medication regimen.

Other uses for this medicine

While Belumosudil is primarily indicated for chronic GVHD, ongoing research may explore its potential use in other conditions related to immune dysregulation or fibrotic diseases. However, as of my last update, its primary approved use is for chronic GVHD.

What special precautions should I follow?

Regarding special precautions for taking Belumosudil, it’s important to follow these guidelines:

  • Pregnancy and Breastfeeding: Belumosudil may cause harm to an unborn baby, so it’s crucial to inform your healthcare provider if you are pregnant or planning to become pregnant. Similarly, breastfeeding mothers should discuss the risks and benefits of Belumosudil with their healthcare provider, as it is not known whether the medication passes into breast milk.
  • Liver and Kidney Function: Belumosudil can affect liver function, so regular monitoring of liver enzymes is recommended during treatment. Additionally, dose adjustments may be necessary in patients with impaired kidney function.
  • Drug Interactions: Belumosudil may interact with other medications, including those metabolized by the cytochrome P450 (CYP) enzyme system. Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
  • Side Effects: Like any medication, Belumosudil can cause side effects. Common side effects include diarrhea, nausea, headache, fatigue, and peripheral edema. Report any unusual or severe side effects to your healthcare provider.
  • Regular Monitoring: Your healthcare provider may conduct regular blood tests to monitor your response to Belumosudil and check for any potential adverse effects.

Always follow your healthcare provider’s instructions and communicate any concerns or questions you may have about taking Belumosudil. They can provide personalized guidance based on your individual health status and medical history.

What special dietary instructions should I follow?

As for special dietary instructions, there are no specific dietary restrictions associated with taking Belumosudil. However, it’s important to maintain a balanced diet and stay hydrated unless advised otherwise by your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Belumosudil, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Belumosudil, like any medication, can cause side effects, although not everyone will experience them. Some of the common side effects associated with Belumosudil include:

  • Diarrhea: This is one of the most common side effects reported by patients taking Belumosudil. It may range from mild to severe and can sometimes lead to dehydration if not managed properly.
  • Nausea: Some individuals may experience feelings of nausea or an upset stomach while taking Belumosudil.
  • Headache: Headaches are another relatively common side effect reported by patients using Belumosudil.
  • Fatigue: Feeling tired or experiencing fatigue is another possible side effect of Belumosudil treatment.
  • Peripheral Edema: Swelling in the hands, feet, ankles, or legs, known as peripheral edema, may occur in some individuals taking Belumosudil.
  • Upper Respiratory Tract Infections: Some patients may develop upper respiratory tract infections such as the common cold while taking Belumosudil.
  • Bruising or Bleeding: Belumosudil may increase the risk of bruising or bleeding in some individuals, particularly if they have existing bleeding disorders or are taking other medications that affect blood clotting.
  • Liver Function Abnormalities: Belumosudil can affect liver function, leading to abnormal liver enzyme levels in some individuals. Regular monitoring of liver function tests is typically recommended during treatment.
  • Decreased Appetite: Some patients may experience a decreased appetite while taking Belumosudil, which can lead to weight loss if severe.

It’s important to note that these are not all the possible side effects of Belumosudil. Some individuals may experience other side effects not listed here. If you experience any unusual or severe side effects while taking Belumosudil, it’s essential to contact your healthcare provider promptly. They can provide guidance on managing side effects and determine whether any adjustments to your treatment are necessary.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of Belumosudil, here’s what you should know:


  • Store Belumosudil tablets at room temperature between 20 to 25°C (68 to 77°F).
  • Keep the medication in its original container, tightly closed, and away from moisture and light.
  • Do not remove the tablets from the blister pack until you are ready to take them.
  • Keep Belumosudil out of reach of children and pets.


  • Dispose of unused or expired Belumosudil tablets properly according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them down the drain unless instructed to do so.
  • Consult your healthcare provider, pharmacist, or local waste disposal authority for information on how to safely dispose of medications.

In case of emergency/overdose

  • In case of an overdose of Belumosudil or if you suspect someone has ingested more than the prescribed amount, seek emergency medical attention immediately.
  • Symptoms of overdose may include severe diarrhea, nausea, vomiting, dizziness, confusion, or fainting.
  • If possible, provide the healthcare provider with information about the amount of medication ingested and when it was taken.

What other information should I know?

  • Keep all appointments with your healthcare provider for regular monitoring and evaluation of your response to Belumosudil.
  • Inform all healthcare providers involved in your care that you are taking Belumosudil, including dentists and pharmacists.
  • Do not share Belumosudil with others, even if they have similar symptoms or conditions.
  • Follow your healthcare provider’s instructions carefully, including dosage adjustments and any dietary or lifestyle recommendations.
  • Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
  • Keep a list of all medications you are taking, including prescription and over-the-counter drugs, as well as any supplements or herbal products, and share this list with your healthcare provider.

By following these guidelines, you can ensure the safe and effective use of Belumosudil while minimizing the risks associated with storage, disposal, and potential emergencies.

Copyright © 2023