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Belumosudil

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Why is this medication prescribed?

Belumosudil is used to treat graft versus host disease (GVHD), a side effect of hematopoietic stem-cell transplantation (HSCT), which replaces diseased bone marrow with healthy bone marrow, in adults and children 12 years of age and older who have received at least two other treatments without success. Belumosudil belongs to the group of drugs known as kinase inhibitors. By suppressing the signals sent by the cells that produce GVHD, it works to treat the condition.

How should this medicine be used?

Belumosudil is available as an oral tablet. Once a day, it is often taken with a meal. Belumosudil should be taken every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Utilize belumosudil precisely as advised. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not chew, break, or crush the tablets; instead, swallow them whole.

Prior to and during your treatment, your doctor will request blood tests to determine how this medicine is affecting you. As part of your treatment, your doctor may adjust your belumosudil dosage or advise you to temporarily stop taking it. This is dependent upon how effectively the drug functions for you, the outcomes of your lab tests, and whether or not you encounter adverse effects. Discuss your feelings regarding your treatment with your doctor. Even if you feel good, keep taking belumosudil. Without consulting your doctor, do not discontinue taking belumosudil.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking belumosudil,

  • If you have an allergy to belumosudil, any other medications, or any of the ingredients in belumosudil tablets, tell your doctor and pharmacist before using belumosudil. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Mention phenobarbital, phenytoin (Dilantin, Phenytek), proton pump inhibitors like dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabe (Rayos).
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • If you have or have previously had liver or kidney disease, let your doctor know.
  • Inform your physician if you are expecting, intend to become pregnant, or intend to father a child. Pregnancy should not occur while you are using belumosudil, either for you or your partner. If you are female, you must have a pregnancy test before starting therapy and use birth control to avoid getting pregnant while taking belumosudil and for one week after your last dosage. If you are a man, you should take birth control with your partner for the duration of your belumosudil therapy and for one week following your last dose in order to avoid getting pregnant. Consult your physician about birth control options you can take while undergoing therapy. Both male and female fertility may be reduced with belumosudil. However, you shouldn’t presumptively believe that neither you nor your partner could conceive. Call your doctor if you or your partner become pregnant while taking belumosudil. The foetus may suffer from belumosudil.
  • If you are breastfeeding, let your doctor know. Throughout your belumosudil treatment and for at least a week following your final dose, you shouldn’t breastfeed.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Belumosudil could have unwanted effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Weakness or fatigue
  • Nausea
  • Having trouble swallowing
  • Breathing difficulty
  • Diarrhea
  • Joint or muscle ache
  • Headache
  • Hands, feet, or facial swelling
  • Itching or rashes

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Fever, chills, sore throat, cough, or other infection-related symptoms
  • Uncommon bruising or bleeding

Other negative effects of belumosudil are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom). Don’t take the desiccant out (small packet included with medication to absorb moisture).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to belumosudil, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Rezurock®
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