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Beleodaq (Generic Belinostat Injection)

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Why is this medication prescribed?

Beleodaq (belinostat) is prescribed for the treatment of peripheral T-cell lymphoma (PTCL), a rare and aggressive type of non-Hodgkin lymphoma. It belongs to a class of medications called histone deacetylase (HDAC) inhibitors, which work by interfering with the growth and spread of cancer cells.

How should this medicine be used?

Beleodaq is administered intravenously (IV), typically over a 30-minute period, once daily for five days in a row every three weeks. The specific dosage and treatment schedule may vary depending on individual patient factors and the prescribing physician’s recommendations.

It’s crucial to follow the dosage instructions provided by your healthcare provider and adhere to the recommended treatment schedule. Additionally, regular monitoring and follow-up appointments with your healthcare team are essential to assess treatment efficacy and manage any potential side effects.

Other uses for this medicine

Beleodaq (belinostat) is primarily indicated for the treatment of peripheral T-cell lymphoma (PTCL). However, healthcare providers may sometimes prescribe it “off-label” for other conditions. Off-label use means using a medication for a purpose other than what it was specifically approved for by regulatory authorities. Any off-label use should be carefully considered and monitored by a healthcare professional.

What special precautions should I follow?

As for special precautions with Beleodaq, here are some important points to keep in mind:

  • Pre-existing Conditions: Inform your healthcare provider about any pre-existing medical conditions you have, such as liver or kidney problems, as well as any other medications, supplements, or herbal remedies you are taking. This information can help your doctor determine if Beleodaq is appropriate for you and if any adjustments to your treatment plan are necessary.
  • Pregnancy and Breastfeeding: Beleodaq can cause harm to a developing fetus, so it’s important to avoid becoming pregnant while taking this medication. If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of Beleodaq with your healthcare provider. It’s also not recommended to breastfeed while receiving Beleodaq treatment.
  • Bone Marrow Suppression: Beleodaq can cause bone marrow suppression, which may lead to decreased levels of red blood cells, white blood cells, and platelets. Your healthcare provider will monitor your blood counts regularly during treatment to detect any signs of bone marrow suppression. If severe suppression occurs, your doctor may need to adjust your dosage or temporarily stop treatment.
  • Liver Toxicity: Beleodaq can cause liver toxicity, which may manifest as elevated liver enzymes or liver damage. Your liver function will be monitored regularly during treatment with Beleodaq. If you experience symptoms such as yellowing of the skin or eyes (jaundice), abdominal pain, or dark urine, contact your healthcare provider immediately.
  • Cardiac Effects: Beleodaq may prolong the QT interval, which can increase the risk of serious cardiac arrhythmias. Inform your healthcare provider if you have a history of heart rhythm disorders or if you are taking medications that can prolong the QT interval. Your doctor may perform cardiac monitoring tests before and during treatment with Beleodaq.
  • Infusion Reactions: Some patients may experience infusion reactions, such as fever, chills, flushing, or shortness of breath, during or shortly after receiving Beleodaq. These reactions are typically mild to moderate in severity and can be managed with supportive care or adjustments to the infusion rate.

Always follow your healthcare provider’s instructions and report any unusual symptoms or side effects promptly. It’s essential to communicate openly with your doctor throughout your treatment with Beleodaq to ensure your safety and well-being.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Beleodaq. However, it’s essential to maintain a healthy and balanced diet to support your overall well-being during cancer treatment. Stay hydrated and consume a variety of nutrient-rich foods, including fruits, vegetables, lean proteins, and whole grains.

What should I do if I forget a dose?

If you forget a dose of Beleodaq, contact your healthcare provider for guidance. It’s important not to double the dose to make up for a missed one. Your doctor may adjust your treatment schedule accordingly. It’s essential to adhere to the prescribed dosing schedule to ensure the effectiveness of your treatment regimen.

What side effects can this medication cause?

Beleodaq (belinostat) can cause various side effects, ranging from mild to severe. Not everyone will experience these side effects, and their severity can vary among individuals. Common side effects of Beleodaq may include:

  • Nausea and vomiting: Feeling nauseous or vomiting is a common side effect of Beleodaq. Your healthcare provider may prescribe medications to help manage these symptoms.
  • Fatigue: Feeling tired or fatigued is another common side effect of Beleodaq. It’s important to get plenty of rest and conserve energy during treatment.
  • Decreased appetite: Some people may experience a loss of appetite while taking Beleodaq, which can lead to weight loss. Eating small, frequent meals and choosing nutrient-rich foods can help maintain adequate nutrition.
  • Diarrhea: Beleodaq may cause diarrhea in some individuals. Drinking plenty of fluids and avoiding foods that can worsen diarrhea, such as spicy or greasy foods, may help manage this side effect.
  • Constipation: On the other hand, some people may experience constipation while taking Beleodaq. Increasing fiber intake, staying hydrated, and staying physically active can help alleviate constipation.
  • Fever: Fever is a common side effect of Beleodaq. If you develop a fever, contact your healthcare provider, as it may indicate an infection or other underlying issue.
  • Headache: Headaches are another possible side effect of Beleodaq. Over-the-counter pain relievers may help alleviate headache symptoms.
  • Insomnia: Difficulty sleeping or insomnia may occur in some individuals taking Beleodaq. Practicing good sleep hygiene and discussing potential interventions with your healthcare provider can help improve sleep quality.
  • Injection site reactions: Beleodaq is administered intravenously, which may cause discomfort or irritation at the injection site. Inform your healthcare provider if you experience any unusual symptoms at the injection site.
  • Low blood cell counts: Beleodaq can suppress bone marrow function, leading to low levels of red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia). This can increase the risk of infections, fatigue, and bleeding. Regular blood tests will monitor your blood cell counts during treatment.

These are not all the possible side effects of Beleodaq. Some individuals may experience other side effects not listed here. It’s essential to report any unusual symptoms or side effects to your healthcare provider promptly. They can provide guidance on managing side effects and adjust your treatment plan if necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Beleodaq:

  • Storage: Beleodaq is typically provided in single-dose vials for intravenous administration. It should be stored at room temperature (20-25°C or 68-77°F) in its original packaging to protect it from light. Do not freeze Beleodaq, and keep it out of reach of children and pets.
  • Disposal: Unused or expired Beleodaq should be disposed of properly according to local regulations. Do not flush Beleodaq down the toilet or pour it down the drain unless instructed to do so. Instead, consult with your healthcare provider or pharmacist about the proper disposal method. They may provide guidance on returning unused medications to a pharmacy or other designated disposal facility.

In case of emergency/overdose

In case of an emergency or suspected overdose with Beleodaq, seek immediate medical attention or contact a poison control center (such as the National Poison Control Center at 1-800-222-1222 in the United States). Symptoms of overdose may include severe nausea, vomiting, diarrhea, dizziness, confusion, or difficulty breathing.

What other information should I know?

  • Dosage: Take Beleodaq exactly as prescribed by your doctor. Do not alter the dosage or stop taking it without consulting your healthcare provider.
  • Side Effects: Beleodaq may cause side effects such as nausea, vomiting, diarrhea, fatigue, and decreased appetite. Notify your doctor if you experience any persistent or severe side effects.
  • Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as they may interact with Beleodaq.
  • Pregnancy and Breastfeeding: Beleodaq may harm an unborn baby. Use effective birth control during treatment and inform your doctor if you become pregnant. It’s not recommended to breastfeed while taking Beleodaq.
  • Regular Monitoring: Your doctor will likely monitor your blood counts and other health parameters regularly during Beleodaq treatment.
  • Follow-up: Attend all scheduled appointments with your healthcare provider to monitor your progress and discuss any concerns or questions you may have.

Always follow your doctor’s instructions carefully and never hesitate to reach out if you have any questions or concerns about Beleodaq or its usage.

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