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Beleodaq (Generic Belinostat Injection)

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Why is this medication prescribed?

Belinostat is used to treat peripheral T-cell lymphoma (PTCL), a type of cancer that develops in specific immune system cells and either does not get better or returns after being treated with other drugs. The drug belinostat belongs to the group of drugs known as histone deacetylase inhibitors. It eliminates cancer cells to work.

How should this medicine be used?

Belinostat is administered intravenously (into a vein) by a doctor or nurse in a hospital or clinic. It is available as a powder that must be combined with fluids. On days one through five of a 21-day cycle, it is typically administered over the course of 30 minutes once daily. The effectiveness of the drug on your body and any adverse effects you encounter will determine how long you need to receive treatment.

If you have certain adverse effects, your doctor might need to change your dosage or stop your therapy. As you have your belinostat injectable therapy, be sure to let your doctor know how you are feeling.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving belinostat injection,

  • If you have any allergies, including to belinostat injection, other drugs, or any of the substances in belinostat injection, notify your doctor right away. Request a list of the components from your pharmacist.
  • While getting belinostat injection, be sure to let your doctor and pharmacist know about any additional prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are using or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have ever undergone chemotherapy treatment with another drug, if you currently have or suspect you may have an infection of any kind, or if you experience nausea, vomiting, or diarrhoea, let your doctor know. If you have kidney or liver illness now or formerly had it, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or intend to father a child. Pregnancy should not occur while a patient is taking a belinostat injection. You must perform a pregnancy test before beginning therapy if you are a female, and you must use birth control to avoid getting pregnant while receiving treatment and for six months after your last dose. If you are a male, you should utilise birth control while taking belinostat and for three months following your last dosage. Consult your physician about birth control options you can take while undergoing therapy. Call your doctor right away if you or your partner become pregnant while receiving a belinostat injectable. Injection of belinostat may be harmful to fetus.
  • Describe to your doctor if you are nursing a baby. While receiving belinostat injection and for two weeks following the last dosage, you shouldn’t breastfeed.
  • You should be aware that this drug may reduce male fertility. Discuss the dangers of obtaining a belinostat injection with your doctor.
  • Inform the surgeon or dentist that you are receiving a belinostat injection if you are undergoing surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from belinostat injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Headache
  • Tiredness
  • Reduction in appetite
  • The injection site hurts
  • Hands, feet, or ankles swelling
  • Rash

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Infection symptoms such as a fever, cough, chills, muscle aches, worsening skin conditions, flu-like symptoms, or other symptoms
  • Urination that is unpleasant, frequent, scorching, or challenging
  • Uncommon bruising or bleeding
  • Weakness, severe fatigue, pallor of the complexion, or shortness of breath
  • Right upper stomach ache, yellowing of the skin or eyes, black urine, or itching

Other negative effects from belinostat injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the belinostat injection, your doctor will request specific lab tests.

You can ask any questions you have regarding your drug to your doctor or pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Beleodaq®
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