Why is this medication prescribed?

Aubagio (generic name: teriflunomide) is prescribed primarily for the treatment of relapsing forms of multiple sclerosis (MS). MS is a chronic autoimmune disease that affects the central nervous system. Aubagio helps manage the disease in the following ways:

• Reduces Relapses: It can help reduce the frequency of relapses (or flare-ups) in people with relapsing forms of MS.
• Slows Disease Progression: It may slow the progression of disability associated with MS.
• Improves Quality of Life: By controlling symptoms and reducing relapses, it can improve overall quality of life for individuals with MS.

Aubagio works by modifying the immune system to reduce inflammation and prevent damage to nerve fibers.

How should this medicine be used?

How Aubagio Should Be Used:

• Dosage: The typical dosage is one 14 mg tablet taken orally once daily. It’s important to follow your healthcare provider’s instructions regarding the exact dosage.
• Administration: Aubagio should be taken with or without food, and it should be taken at the same time each day to help remember to take it.
• Monitoring: Regular blood tests may be required to monitor liver function and to ensure the medication is not causing any unwanted effects.

Always consult with your healthcare provider for personalized advice and instructions based on your specific situation.

Other uses for this medicine

Currently, Aubagio is primarily used for treating relapsing forms of multiple sclerosis (MS). Its efficacy for other conditions is not well-established or approved.

What special precautions should I follow?

Special Precautions for Aubagio:

• Liver Function Monitoring: Regular monitoring of liver function is essential, as Aubagio can cause liver enzyme abnormalities. Inform your healthcare provider if you experience symptoms of liver problems, such as jaundice, dark urine, or abdominal pain.
• Pregnancy and Birth Control: Aubagio is not recommended during pregnancy due to potential risks to the fetus. Effective birth control is advised during treatment and for two years after discontinuing the medication. If you become pregnant or plan to become pregnant, inform your healthcare provider immediately.
• Infections: Aubagio can affect the immune system, making you more susceptible to infections. Report any signs of infection, such as fever or persistent sore throat, to your healthcare provider.
• Blood Pressure: Monitor your blood pressure regularly, as Aubagio can sometimes cause high blood pressure.
• Kidney Function: Although rare, Aubagio may affect kidney function. Regular kidney function tests might be recommended.
• Drug Interactions: Inform your healthcare provider of all other medications you are taking, including over-the-counter drugs and supplements, as Aubagio can interact with other medications.
• Vaccinations: Certain vaccinations may not be recommended while on Aubagio. Consult with your healthcare provider about which vaccines are appropriate for you.
• Stopping Treatment: If you need to stop Aubagio, your healthcare provider will likely recommend a specific procedure to help remove the medication from your system safely, as it can stay in your body for an extended period.

Always follow your healthcare provider’s advice and inform them of any concerns or side effects you experience while on Aubagio.

What special dietary instructions should I follow?

• No Specific Dietary Restrictions: Aubagio does not have specific dietary restrictions. However, maintaining a balanced diet can help overall health and potentially reduce side effects.
• Hydration: Ensure adequate hydration, especially if you experience gastrointestinal side effects like diarrhea.

What should I do if I forget a dose?

• Take it as Soon as Possible: If you remember within 12 hours of the missed dose, take it as soon as you remember.
• Skip the Dose if Almost Time for the Next One: If it’s almost time for your next dose, skip the missed dose and take your next dose at the usual time.
• Do Not Double Up: Do not take two doses at once to make up for a missed dose.
• Consult Your Healthcare Provider: If you have missed doses frequently or are unsure about what to do, consult your healthcare provider for specific instructions.

What side effects can this medication cause?

Aubagio (teriflunomide) can cause a range of side effects. Some of the common and serious side effects include:

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Hair loss
• Rash

Serious Side Effects:

• Liver Problems: Elevated liver enzymes or liver injury. Symptoms include jaundice (yellowing of the skin or eyes), dark urine, and abdominal pain.
• Infections: Increased risk of infections due to immune system suppression. Watch for signs like fever, persistent sore throat, or unusual bleeding or bruising.
• High Blood Pressure: Increased risk of hypertension. Regular monitoring of blood pressure is recommended.
• Peripheral Neuropathy: Tingling, numbness, or pain in the hands or feet.
• Severe Allergic Reactions: Symptoms such as swelling of the face or throat, severe rash, or difficulty breathing.
• Pregnancy Risks: Not recommended during pregnancy due to potential harm to the fetus.

If you experience any severe or unusual side effects, contact your healthcare provider immediately. Regular check-ups and monitoring can help manage and mitigate potential risks.

What should I know about storage and disposal of this medication?

Storage and Disposal of Aubagio:

• Storage:
  • Store Aubagio at room temperature, between 68°F to 77°F (20°C to 25°C).
  • Keep it in its original container, tightly closed, and away from moisture and light.
  • Do not store it in the bathroom.
• Disposal:
  • Do not dispose of Aubagio in household trash or flush it down the toilet.
  • Follow any specific disposal instructions provided by your pharmacist or healthcare provider.
  • If no specific instructions are provided, take the medication to a drug take-back program or follow local guidelines for medication disposal.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms of an overdose may not be well-documented, but you might experience severe side effects or unexpected reactions. If you suspect an overdose, seek medical attention immediately.
• Actions: Contact emergency medical services or go to the nearest emergency room. Provide information about the medication, dosage, and when it was taken to the medical professionals.

What other information should I know?

• Missed Doses: If you miss a dose, follow the instructions mentioned earlier. Do not double the dose to make up for a missed one.
• Regular Monitoring: Regular visits to your healthcare provider for blood tests and check-ups are important to monitor liver function and other potential side effects.
• Interactions: Be aware of potential interactions with other medications, including over-the-counter drugs and supplements. Inform your healthcare provider of all medications you are taking.
• Pregnancy and Birth Control: As mentioned, effective birth control is crucial during treatment and for two years after stopping Aubagio.
• Symptom Tracking: Keep track of any new or worsening symptoms and report them to your healthcare provider promptly.

Always consult your healthcare provider for personalized advice and information regarding your specific situation.