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Astramorph PF (Generic Morphine Injection)

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Injections of morphine have the potential to become habits, especially over time. Inject morphine exactly as instructed. Use it only as prescribed by your doctor, and don’t take more of it, use it more frequently, or use it in a different way. Discuss your pain management objectives, course of treatment, and additional pain management options with your healthcare provider while you are taking morphine. Inform your doctor if you or any family members regularly use significant amounts of alcohol, take street drugs, abuse prescription drugs excessively, experience overdosing, or currently suffer from depression or another mental disorder. If you currently have or have ever had any of these conditions, there is a higher chance that you may misuse morphine. If you suspect that you may have an opioid addiction, speak with your doctor right away and ask for advice, or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

During the first 24 to 72 hours of treatment and whenever your dose is raised, morphine may seriously or fatally impair your ability to breathe. Throughout your therapy, your doctor will keep a close eye on you. If you have asthma or slow breathing, let your doctor know. Most likely, your doctor will advise against using morphine injection. Additionally, let your physician know if you now have or previously had a lung condition like chronic obstructive pulmonary disease (COPD), a group of illnesses that affect the lungs and airways, a head injury, a brain tumour, or any other condition that raises the pressure inside of your skull. The likelihood that you will experience breathing issues may be increased if you are an older adult, weak, or undernourished as a result of a sickness. Get emergency medical care if you encounter any of the following symptoms, or call your doctor right away: sluggish breathing, protracted breath gaps, or shortness of breath.

While receiving therapy with morphine injection, taking some drugs may raise your chance of developing significant or life-threatening respiratory issues, drowsiness, or coma. Inform your doctor if you are currently taking or intend to take any of the following drugs: benzodiazepines such estazolam, flurazepam, lorazepam, triazolam (Halcion), medications for mental illness discomfort or nausea, muscle relaxants, sedatives, sleeping pills, or tranquillizers. Your doctor will closely monitor you and may need to adjust the dosage of your drugs. Call your doctor right away if you experience any of the following symptoms while taking any of these drugs with morphine injection: unusual dizziness, lightheadedness, extreme drowsiness, slowed or laboured breathing, or inability to respond. If you are unable to seek treatment on your own, make sure your caregiver or family members are aware of any symptoms that may be dangerous so they can contact the doctor or emergency services.

You run a higher chance of developing these severe, potentially fatal adverse effects while receiving therapy with morphine injection if you consume alcohol, take prescription or over-the-counter treatments that include alcohol, or use illicit substances. During your treatment, refrain from drinking alcohol, taking alcohol-containing prescription or over-the-counter medications, or using illegal substances.

Do not share your medication with anybody else. Children especially may be harmed or killed by morphine when they take your prescription.

If you are pregnant or want to become pregnant, let your doctor know. Regular morphine usage during pregnancy increases the likelihood that your unborn child will have potentially fatal withdrawal symptoms. If your infant exhibits any of the following symptoms, contact your doctor straight away: irritability, hyperactivity, disturbed sleep, high-pitched crying, excessive shaking of a body part, vomiting, diarrhoea, or failure to gain weight.

Discuss the dangers of using morphine injection with your doctor.

Why is this medication prescribed?

Injections of morphine are used to treat moderate to severe pain. The group of drugs known as opiate (narcotic) analgesics includes morphine. It functions by altering how the nerve system and brain react to pain.

How should this medicine be used?

Injections of morphine are available as solutions (liquids) to administer intravenously or intramuscularly (into a vein). As needed, it is typically injected once every four hours. Use morphine injections daily at around the same times. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Inject morphine exactly as instructed.

During treatment, your doctor may change the amount of morphine injection you receive, based on how effectively your pain is managed and any adverse effects you encounter. Discuss your feelings regarding your morphine injection therapy with your doctor.

Do not abruptly cease taking morphine injection if you have been using it for more than a few days. The withdrawal symptoms that you might experience if you abruptly stop using morphine injection include agitation, teary eyes, runny noses, yawning, sweating, chills, muscle, back, or joint pain, widening of the pupils, irritability, anxiety, weakness, stomach cramps, trouble falling or staying asleep, nausea, loss of appetite, vomiting, diarrhoea, fast breathing, or rapid heartbeat. Your dose will likely be gradually reduced by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using morphine injection,

  • If you have an allergy to morphine, any other drugs, or any of the substances in morphine injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Lithium (Lithobid, in Librax), cimetidine (Tagamet), cyclobenzaprine (Amrix), antihistamines (used in cold and allergy treatments); Almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); 5HT3 serotonin blockers like alosetron (Lotronex), Selective serotonin-reuptake inhibitors like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors like desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor); tramadol (Surmontil). Additionally, let your doctor or pharmacist know if you’re receiving any of the following monoamine oxidase (MAO) inhibitors or if you’ve recently stopped taking them: methylene blue, isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Tell your doctor about all of the medications you are taking, even any not on this list, as many other drugs may also interact with morphine. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have paralytic ileus or any of the symptoms listed in the IMPORTANT WARNING section, let your doctor know very once (condition in which digested food does not move through the intestines). Your doctor might advise against using morphine.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Inform your doctor if you have or have previously had renal, liver, or cardiac illness, as well as low blood pressure.
  • Inform your doctor if you are nursing a child.
  • You should be aware that this medicine may lower both male and female fertility. The dangers of morphine use should be discussed with your doctor.
  • Tell the doctor or dentist that you are using morphine if you are having surgery, including dental surgery.
  • You should be aware that taking this medication could make you sleepy. Before you know how this prescription affects you, do not operate machinery or drive a car.
  • You should be aware that when you get up too rapidly from a laying position, morphine may cause lightheadedness, dizziness, and fainting. To avoid this issue, slowly get out of bed and sit up after a few minutes of resting your feet on the floor.
  • You should be aware that morphine might result in constipation. While using morphine, discuss with your doctor whether you should alter your diet or take other medications to avoid or cure constipation.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Morphine could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Dizziness
  • Lightheadedness
  • Mood shifts

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Seizures
  • Breathing more slowly
  • Breaths between long pauses
  • Breathing difficulty
  • Hallucinations (seeing or hearing objects or voices that aren’t there), agitation, sweating excessively, confusion, rapid heartbeat, shivering, extremely rigid or twitching muscles, loss of coordination, nausea, vomiting, or diarrhoea
  • Nausea, vomiting, appetite loss, exhaustion, or lightheadedness
  • Failure to achieve or maintain erection
  • Abnormal menstruation
  • Reduced sexual arousal
  • Itching
  • Rash
  • Hives

Other negative effects of morphine may occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

You should speak with your doctor about keeping a rescue drug called naloxone on hand when using morphine injection (e.g., home, office). Naloxone is used to undo an overdose’s potentially fatal consequences. To treat harmful symptoms brought on by excessive levels of opiates in the blood, it functions by inhibiting the effects of opiates. If you live with young children or someone who has abused prescription or illicit drugs, your doctor could also advise you to get naloxone. Make sure you, your family, your caretakers, and anyone else who spends time with you are aware of the signs of an overdose, how to administer naloxone, and what to do until emergency assistance arrives. You and your family members will be shown how to use the medication by your doctor or pharmacist. For the directions, speak to your pharmacist or go to the manufacturer’s website. If you start to experience overdose symptoms, a friend or family member should administer the first dose of naloxone, contact 911 right away, and stay by your side while keeping a careful eye on you until emergency medical assistance comes. After receiving naloxone, your symptoms can come back a short while later. The person should administer you another dose of naloxone if your symptoms come back. If symptoms reappear before receiving medical attention, more doses may be given every 2 to 3 minutes.

Overdose signs could include the following:

  • Uneven, shallow, or slow breathing
  • Having trouble breathing
  • Sleepiness
  • Not able to speak or awaken
  • Clammy, frigid skin
  • Little eyes
  • Sluggish heartbeat
  • Fuzzy vision
  • Nausea
  • Fainting

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how your body reacts to morphine, your doctor may request specific lab tests.

Inform your doctor and the lab staff that you are using morphine prior to any laboratory test (particularly ones involving methylene blue).

This medication cannot be renewed. Make sure to arrange meetings with your doctor if you often use morphine to manage your pain so that you never run out of the drug. If you are using morphine for a brief period of time, contact your doctor if your pain persists after the drug has worn off.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Astramorph® PF
  • Duramorph®
  • Infumorph®
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