Acute lymphocytic leukaemia (ALL; a type of cancer of the white blood cells) and a type of non-Hodgkins lymphoma (NHL; cancer that starts in a type of white blood cell that normally fights infection) are both treated in adults and children aged one month and older with asparaginase erwinia chrysanthemi (recombinant)-rywn injection in combination with other chemotherapy drugs. It is prescribed to patients who have experienced allergic responses to certain forms of asparaginase erwinia chrysanthemi (recombinant)-rywn medicines, including asparaginase (Elspar). An enzyme called asparaginase erwinia chrysanthemi (recombinant)-rywn prevents the natural compounds required for the formation of cancer cells. It stops the growth of cancer cells or kills them.

Recombinant asparaginase erwinia chrysanthemi is administered intramuscularly (injected into a muscle) by a physician or nurse in a healthcare setting. Usually, it is administered every 48 hours. How you react to the drug will determine how long the treatment will last.

If you encounter particular side effects, your doctor might need to postpone or terminate your treatment. It is crucial that you communicate your feelings to your doctor as you receive the asparaginase erwinia chrysanthemi (recombinant)-rywn injection.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving asparaginase erwinia chrysanthemi (recombinant)-rywn,

• If you have an allergy to asparaginase erwinia chrysanthemi (recombinant)-rywn, any other medications, or any of the ingredients in asparaginase erwinia chrysanthemi (recombinant)-rywn, inform your doctor and pharmacist right away. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your physician if you now have or have ever experienced asparaginase treatment-related pancreatitis (pancreatic enlargement), blood clots, or serious bleeding (Elspar). You won’t likely be prescribed asparaginase erwinia chrysanthemi (recombinant)-rywn by your doctor.
• Inform your doctor of any medical issues you now have or have ever had.
• Inform your doctor if you are expecting a child or if you intend to do so. You must perform a pregnancy test before beginning therapy, and you must use a non-hormonal birth control during treatment and for three months following your last dose (a contraceptive that prevents sperm from entering the uterus, such as a condom or a diaphragm). During your therapy, discuss birth control options with your doctor. Call your doctor right away if you fall pregnant while taking recombinant asparaginase from Erwinia Chrysanthemi. Recombinant asparaginase from Erwinia Chrysanthemi may be harmful to the foetus.
• Inform your doctor if you are nursing a child. While taking asparaginase erwinia chrysanthemi (recombinant)-rywn and for 1 week following the last dose, breastfeeding should be avoided.

Keep eating normally unless your doctor instructs you otherwise.

There could be negative effects from asparaginase erwinia chrysanthemi (recombinant)-rywn. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Diarrhea
• Constipation
• Bone or muscle ache
• Headache
• Tiredness
• Fever, chills, cough, or other infection-related symptoms
• Reduced appetite
• Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Swelling of the arms, legs, lips, face, or eyes
• Hives
• Itching
• Rash or redness
• Rrespiratory issues or shortness of breath
• Yellowing of the skin or eyes, discomfort in the upper right stomach region, black urine, or loss of appetite
• Uncommon bruising or bleeding
• Uurethral blood
• Chest pain, difficulty of breath, swollen arms or legs
• Nausea, vomiting, severe stomach discomfort, fever, and weight loss

Other negative consequences could result from asparaginase erwinia chrysanthemi (recombinant)-rywn. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. To determine how your body will react to asparaginase erwinia chrysanthemi (recombinant)-rywn, your doctor will request a number of lab tests.

Any queries you may have regarding asparaginase erwinia chrysanthemi (recombinant)-rywn should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.