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Arranon (Generic Nelarabine Injection)

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Only a physician with training in the administration of chemotherapy drugs for cancer should administer nelarabine injection.

Your nervous system could sustain significant harm from nelarabine, damage that might persist long after you stop taking the drug. Inform your doctor if you have ever been radiation therapy to the brain or spine, undergone chemotherapy administered directly into the fluid around the brain or spine, or if you currently have or have ever experienced any neurological issues. While you receive nelarabine injection and for at least 24 hours following each dosage, a doctor or nurse will keep an eye on you. Call your doctor right away if you have any of the following symptoms: excessive drowsiness, confusion, tingling or numbness in the hands, feet, or toes, issues with fine motor skills like buttoning clothes, weakness of the muscles; Weakness when getting out of a low chair or mounting stairs, increased tripping when walking on uneven surfaces, uncontrollable shaking of a body part, a loss of touch, the inability to move any part of the body, seizures, or coma are all examples of unsteadiness (loss of consciousness for a period of time).

You should discuss the dangers of using nelarabine with your doctor.

Why is this medication prescribed?

Nelarabine is used to treat specific forms of lymphoma (cancer that starts in immune system cells) and leukaemia (cancer that starts in white blood cells) that have not improved or returned after being treated with other drugs. Nelarabine belongs to the group of drugs known as antimetabolites. It eliminates cancer cells to work.

How should this medicine be used?

In a hospital or clinic, a doctor or nurse administers nelarabine injection intravenously (into a vein). On the first, third, and fifth days of the dosing cycle, it is typically administered to adults once daily. Children often receive it once daily for five days. Typically, this procedure is done every 21 days. If you have certain adverse effects, your doctor might postpone your therapy.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using nelarabine injection,

  • If you have an allergy to nelarabine, any other drugs, or any of the ingredients in nelarabine injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Adenosine deaminase inhibitors like pentostatin should be mentioned (Nipent). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have kidney or liver problems now or in the past, let your doctor know.
  • If you or your partner are expecting a child, let your doctor know right away. You must perform a pregnancy test if you are a female before starting nelarabine treatment, and you shouldn’t get pregnant while taking it. If you’re a man, you should use birth control while receiving therapy and for three months following your last dose, together with your female partner. Consult your physician about birth control options you can take while undergoing therapy. Call your doctor right away if you or your partner become pregnant while taking nelarabine. The foetus could suffer from nelarabine.
  • Inform your doctor if you are nursing a child. While taking nelarabine, you shouldn’t breastfeed.
  • Inform the surgeon or dental surgeon that you are taking nelarabine if you are having surgery, including dental surgery.
  • Nelarabine has the potential to make you sleepy, so be aware of that. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • Avoid getting any immunizations while receiving nelarabine without first consulting your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you can’t make it to a scheduled visit to get a dose of nelarabine, call your doctor right away.

What side effects can this medication cause?

Nelarabine could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Reduced appetite
  • An aching or swollen stomach
  • Bruises on the tongue or lips
  • Headache
  • Dizziness
  • Having trouble falling or staying asleep
  • Depression
  • Pain in your back, muscles, arms, or legs
  • Hand, arm, foot, ankle, or lower leg swelling
  • Distorted vision

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Light skin
  • Breathing difficulty
  • Rapid heart rate
  • Chest pain
  • Cough
  • Wheezing
  • Uncommon bruising or bleeding
  • Nosebleeds
  • Skin with tiny red or purple spots
  • Fever, chills, sore throat, or other symptoms of infection
  • Severe thirst
  • Less urinations
  • Recessed eyes
  • Dry skin and mouth

Other negative effects of nelarabine could exist. If you experience any strange issues while taking this drug, call your doctor right away.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Light skin
  • Breathing difficulty
  • Extreme fatigue
  • Fever, chills, sore throat, or other symptoms of infection
  • Abnormal bleeding or bruising
  • Tingling and numbness in the toes, foot, fingers, or hands
  • Confusion
  • Muscle tremor
  • No capacity to move any body part
  • Seizures
  • Coma

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to nelarabine, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Arranon®
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