WARNING

Arixtra is an anticoagulant used to prevent and treat deep vein thrombosis (DVT), pulmonary embolism (PE), and to prevent blood clots after certain surgeries. Here are the main risks associated with taking Arixtra:

• Bleeding: The most significant risk is bleeding, which can be severe or even life-threatening. This includes internal bleeding and bleeding in the brain.
• Allergic Reactions: Some people may experience allergic reactions, including rash, itching, or swelling.
• Thrombocytopenia: A rare but serious condition where the platelet count in the blood drops, increasing the risk of bleeding.
• Spinal/Epidural Hematoma: If Arixtra is used in patients with epidural or spinal anesthesia, there’s a risk of developing a hematoma, which could lead to long-term or permanent paralysis.
• Kidney Impairment: Use with caution in patients with kidney problems, as it may require dose adjustments.
• Interactions: It can interact with other medications, increasing the risk of bleeding or affecting the drug’s efficacy.

Patients taking Arixtra should be monitored regularly by their healthcare provider to manage these risks effectively.

Why is this medication prescribed?

Arixtra (fondaparinux) is prescribed primarily for its anticoagulant properties. Here’s why it might be prescribed and how it should be used:

• Prevention of Deep Vein Thrombosis (DVT): After surgeries such as hip or knee replacement, Arixtra helps prevent blood clots in the deep veins of the legs.
• Treatment of Deep Vein Thrombosis (DVT): It is used to treat existing DVT and to prevent the clot from getting larger.
• Treatment of Pulmonary Embolism (PE): Arixtra helps manage and treat pulmonary embolism, a condition where blood clots travel to the lungs.
• Prevention of Blood Clots: In patients undergoing certain types of surgeries or those at high risk of developing blood clots, Arixtra reduces the likelihood of clot formation.

How should this medicine be used?

Arixtra should be used as follows:

• Administration: Arixtra is administered as an injection under the skin (subcutaneously), usually in the abdomen. The injection is typically done once daily.
• Dosage: The exact dosage depends on the condition being treated and the patient’s individual health factors. It’s important to follow the prescribed dose and schedule closely.
• Injection Technique: Proper technique is crucial. Inject into the fatty tissue of the abdomen, rotating sites to avoid irritation. Do not inject into areas where the skin is bruised or swollen.
• Monitoring: Regular blood tests may be required to monitor for any signs of bleeding or to check kidney function, depending on the patient’s health status.
• Missed Dose: If a dose is missed, it should be administered as soon as remembered. If it is almost time for the next dose, skip the missed dose; do not double up.

Patients should follow their healthcare provider’s instructions carefully and report any unusual symptoms or side effects immediately.

Other uses for this medicine

• Post-Surgical Clot Prevention: Beyond DVT and PE, Arixtra may be used to prevent clots in patients undergoing other types of major surgeries, such as abdominal or pelvic surgeries.
• Acute Coronary Syndrome: In some cases, Arixtra may be used in the treatment of acute coronary syndrome (ACS) to prevent clot formation in patients with unstable angina or myocardial infarction.

What special precautions should I follow?

Special Precautions for Arixtra:

• Bleeding Risk: Arixtra increases the risk of bleeding. Inform your healthcare provider if you have any history of bleeding disorders, recent surgeries, or trauma. Report any unusual bleeding, bruising, or signs of blood in urine or stool.
• Kidney Function: Since Arixtra is eliminated through the kidneys, dose adjustments may be needed for patients with impaired kidney function. Regular monitoring of kidney function is important.
• Allergic Reactions: Watch for signs of allergic reactions, including rash, itching, or swelling. If these occur, seek medical advice promptly.
• Pregnancy and Breastfeeding: Arixtra should be used during pregnancy only if clearly needed. Discuss with your healthcare provider if you are pregnant or breastfeeding.
• Epidural/Spinal Anesthesia: Use with caution if you are undergoing epidural or spinal anesthesia due to the risk of hematoma, which could lead to paralysis.
• Interactions with Other Medications: Inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements, as Arixtra can interact with other anticoagulants or medications.
• Injection Technique: Proper technique is crucial to avoid complications. Follow instructions on how to administer the injection and rotate injection sites to prevent irritation.
• Medical Conditions: If you have conditions such as liver disease, severe hypertension, or a history of stroke, inform your healthcare provider, as these may influence the safety and dosage of Arixtra.

Always follow your healthcare provider’s instructions and report any side effects or concerns promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions or requirements while taking Arixtra. However, maintaining a balanced diet and avoiding excessive alcohol consumption can help manage overall health and reduce bleeding risks. Always consult your healthcare provider if you have specific dietary concerns or if you are on a restricted diet.

What should I do if I forget a dose?

• Missed Dose: If you miss a dose of Arixtra, take it as soon as you remember.
• Close to Next Dose: If it is almost time for your next dose, skip the missed dose; do not double up to make up for a missed dose.
• Consult Your Healthcare Provider: For specific instructions tailored to your situation, especially if you’re unsure about how to proceed after missing a dose, consult your healthcare provider for guidance.

What side effects can this medication cause?

Aristogel (triamcinolone topical) may cause some side effects, although not everyone experiences them. Common side effects include:

• Skin Irritation: Redness, burning, itching, or dryness at the application site.
• Skin Thinning: Prolonged use may lead to thinning of the skin, which can make it more susceptible to injury or infection.
• Stretch Marks: The skin may develop stretch marks in areas where the gel has been applied.
• Infections: Increased risk of bacterial, fungal, or viral infections at the application site.
• Acne or Folliculitis: Breakouts or inflammation of hair follicles may occur.
• Allergic Reactions: Rarely, some people may experience a rash, swelling, or other signs of an allergic reaction.

If you experience severe side effects or symptoms such as severe itching, rash, swelling, or signs of an infection, contact your healthcare provider promptly. Additionally, if you notice any symptoms that concern you or are unexpected, it’s important to discuss them with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Arixtra:

Storage:

• Store Arixtra at room temperature, away from direct light and moisture. The typical range is between 68°F and 77°F (20°C and 25°C).
• Do not refrigerate or freeze the medication.
• Keep the medication out of reach of children and pets.

Disposal:

• Dispose of unused or expired Arixtra properly. Do not flush it down the toilet or throw it in the trash.
• Use a drug take-back program or follow local guidelines for disposal of medications.
• If you are unsure how to dispose of Arixtra, consult your pharmacist or healthcare provider for advice.

In case of emergency/overdose

• Overdose Symptoms: Symptoms of an overdose may include severe bleeding or unusual bruising.
• Seek Medical Attention: If you suspect an overdose, seek emergency medical help immediately.
• Contact Poison Control: You may also contact your local poison control center for guidance on what to do next.
• Emergency Care: Provide healthcare professionals with information about the medication you took, including the dose and timing.

What other information should I know?

• Regular Monitoring: Regular blood tests and medical check-ups may be required to monitor the effects of Arixtra and manage any potential side effects.
• Medical History: Inform your healthcare provider about your complete medical history, including any conditions that could affect the use of Arixtra.
• Follow-Up Care: Adhere to follow-up appointments and treatment plans to ensure the medication is working effectively and to address any concerns.
• Emergency Contact: Always have contact information for your healthcare provider and emergency services available in case of sudden health issues or side effects.

By following these guidelines, you can help ensure the safe and effective use of Arixtra.