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Arixtra (Generic Fondaparinux Injection)

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You run the chance of developing a blood clot in or near your spine if you have an epidural, spinal anaesthetic, or spinal puncture while taking a “blood thinner” like fondaparinux injection. This could leave you paralysed. Inform your doctor if you have ever undergone spinal surgery, are currently taking pain medication through your spine, have a spinal deformity, or experience bleeding issues. Aspirin, non-steroidal anti-inflammatory medicines (ibuprofen, naproxen), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine), eptifibatide (Integrilin), prasugrel (Effient), ticlopidine, and tirofiban are examples of other anticoagulants (also known as “blood thinners”) (Aggrastat). Call your doctor right away if you suffer any of the following symptoms: muscle weakness, tingling or numbness (particularly in your legs), or immobility in your legs.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to fondaparinux injection, your doctor might prescribe specific tests.

Discuss the dangers of using fondaparinux injection with your doctor.

Why is this medication prescribed?

In patients undergoing hip surgery, hip or knee replacement surgery, or abdominal surgery, fondaparinux injection is used to avoid deep vein thrombosis (DVT; a blood clot, typically in the leg), which can result in pulmonary embolism (PE; a blood clot in the lung). Additionally, it is utilised in conjunction with warfarin (Coumadin, Jantoven) to treat PE or DVT. Factor Xa inhibitors are a group of drugs that includes fondaparinux injection. It functions by lessening the blood’s capacity to clot.

How should this medicine be used?

The injection of fondaparinux is administered subcutaneously, or just beneath the skin, in the lower stomach region. It is typically administered once daily for 5 to 9 days, however it may also be given for as long as 1 month. At least 6 to 8 hours after your surgery, you’ll probably start utilising fondaparinux injection while you’re still in the hospital. Inject fondaparinux at roughly the same time each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Administer fondaparinux injection as prescribed. Never inject more, less, or more frequently than your doctor has instructed.

If you intend to continue using fondaparinux after your hospital stay, you can administer the injections yourself or have a friend or family member help. To learn how to inject a medicine, ask your doctor or pharmacist to demonstrate it to you or the person doing the injecting. Read the included Patient Information before administering fondaparinux injection on your own for the first time. This material covers instructions for using and injecting prefilled safety syringes with fondaparinux. If you have any concerns regarding how to inject this drug, be sure to consult your doctor or pharmacist.

There is enough medication in each syringe to give one shot. The syringe and needle should only be used once. How to properly dispose of used needles and syringes will be explained to you by your doctor, pharmacist, or other healthcare professional.

With other medications or solutions, do not combine fondaparinux injection.

Other uses for this medicine

The injection of fondaparinux is occasionally used to aid in the prevention of blood clots in persons who have suffered a heart attack. The dangers of using this drug for your illness should be discussed with your doctor.

What special precautions should I follow?

Before using fondaparinux injection,

  • If you experienced any of the following extreme adverse reactions to fondaparinux: trouble breathing or swallowing; swelling of the face, throat, tongue, lips, or eyes. Most likely, your doctor will advise against using fondaparinux. Additionally, let your doctor know if you have any drug or fondaparinux injectable ingredient allergies. Request a list of the components from your pharmacist. If you have a latex allergy, let your doctor and pharmacist know as well.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention all of the drugs that are listed in the IMPORTANT WARNING section. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you weigh less than 110 pounds (50 kg), experience bleeding anywhere on your body, have a low platelet count, have endocarditis (a heart infection), or have renal problems. Most likely, your doctor will advise against using fondaparinux injection.
  • Inform your doctor if you have or have had had liver illness, high blood pressure, a stroke or ministroke (TIA), stomach or intestinal ulcers, or eye disease brought on by diabetes. Additionally, let your doctor know if you’ve recently had spinal, brain, or eye surgery.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you get pregnant while taking fondaparinux injectable.
  • Inform the surgeon or dentist that you are taking fondaparinux injection if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you realise you missed a dose, administer it. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Don’t administer more than one injection of fondaparinux at once.

What side effects can this medication cause?

The injection of fondaparinux may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Bruising, bleeding, or a rash at the injection site
  • Dizziness
  • Confusion
  • Light skin
  • Bruises on the skin
  • Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of these signs or any of the ones detailed in the IMPORTANT WARNING section:

  • Uncommon bruising or bleeding
  • Patches of dark redness in the mouth or beneath the skin
  • Hives
  • Face, throat, tongue, lips, or eye swelling
  • Breathing or swallowing challenges

Other adverse effects after fondaparinux injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The best way to preserve your medication will be advised by your doctor. Just as instructed, keep your medication out of children’s reach when storing it. Be sure to know the right way to store your medications. Keep fondaparinux injection from freezing.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Bleeding

What other information should I know?

Inform the lab staff and your doctor that you are receiving fondaparinux injection prior to any laboratory test.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Arixtra®
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