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Aptivus (Generic Tipranavir)

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When used with ritonavir [Norvir], tipranavir may result in brain haemorrhage. It’s possible that this illness will kill you. If you recently underwent surgery or sustained any type of injury, let your doctor know. Inform your physician if you suffer from a bleeding issue like haemophilia (condition in which the blood does not clot normally). Inform your physician and pharmacist if you are taking any of the following drugs: heparin, nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen), prasugrel (Effient), ticlopidine, or tirofiban. Anticoagulants (also known as “blood thinners”) include warfarin (Coumadin, Jantoven), aspirin or products containing aspirin, cilostazol, clopidogrel (Pl (Aggrastat). If you take vitamin E in amounts above those seen in a typical daily multivitamin, you should also let your doctor and pharmacist know. Inform all of your medical professionals that you are taking tipranavir if you require emergency care for any reason. If you develop unusual bleeding or bruising while taking tipranavir, call your doctor right once.

Tipranavir (when used with ritonavir [Norvir]) may result in potentially fatal liver damage. Inform your doctor if you now or previously had hepatitis (viral-induced liver swelling), any other liver diseases, or if you currently or ever consumed alcohol. Call your doctor right away and stop taking tipranavir if you have any of the following symptoms: fatigue, weakness, flu-like symptoms, nausea, vomiting, lack of appetite, right-sided soreness, ache, or sensitivity, yellowing of the skin or eyes, dark (tea-colored) urine, or pale bowel motions.

Keep all of your appointments with your physician and the lab. In order to monitor your body’s response to tipranavir, your doctor will prescribe a number of tests.

Consult your physician on the hazards of taking tipranavir.

Why is this medication prescribed?

In order to treat human immunodeficiency virus infection, ritonavir (Norvir) and other drugs are combined with tipranavir (HIV). Tipranavir belongs to the class of drugs known as protease inhibitors. It functions by lowering the level of HIV in the blood. Although tipranavir does not treat HIV, it may lessen your risk of getting AIDS and other diseases connected to HIV, such as serious infections or cancer. The risk of spreading the HIV virus to others may be reduced by taking these medications, engaging in safer sexual behaviour, and changing other aspects of one’s lifestyle.

How should this medicine be used?

Both a liquid oral solution and a capsule form of tipranavir are available for consumption. Tipranavir is typically taken twice day, with or without food, in combination with ritonavir capsules or solution. Tipranavir is often taken twice day with meals if ritonavir pills are also taken. Ritonavir and tipranavir should be taken at roughly the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take tipranavir as prescribed by your doctor. Never take it in larger or less amounts or more frequently than directed by your doctor.

Tipranavir should not be taken without ritonavir.

Do not chew or crush the capsules; instead, swallow them whole. You should let your doctor or pharmacist know if you are unable to swallow the capsules.

Although it does not treat HIV infection, tipranavir aids in its management. Tipranavir should still be taken even if you feel OK. Without consulting your doctor, do not discontinue taking tipranavir. Your disease may get harder to treat if you stop taking tipranavir or skip doses. Ask your doctor or pharmacy for additional tipranavir when you start to run low on it.

For a copy of the manufacturer’s information for the patient, ask your doctor or pharmacist. If you have any questions, make sure you thoroughly read this information and consult your doctor or pharmacist.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking tipranavir,

  • If you have an allergy to tipranavir, ritonavir (Norvir, in Kaletra), sulfa drugs, any other drugs, or any of the substances in tipranavir capsules or solution, let your doctor and pharmacist know right once. If you are unsure whether a medication to which you are allergic is a sulfa medication, ask your pharmacist. A list of the contents in tipranavir capsules or solution can also be obtained from your pharmacist.
  • If you are using any of the following drugs or natural remedies, let your doctor know: Alfuzosin (Uroxatral), cisapride (Propulsid) (no longer available in the United States), ergotamine (Ergomar, in Cafergot, in Migergot, among others), or methylergonovine (Methergine) are ergot-based medications that can be used to treat migraines. Other medications for irregular heartbeat include amiodarone (Nexterone, Pacerone), flecainide, and Midazolam by mouth, pimozide (Orap), lovastatin (Altoprev), lurasidone (Latuda), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), sildenafil (Revatio) for the treatment of pulmonary arterial hypertension, simvastatin (Zocor, in Vytorin), St. John’s wort (Halcion). If you are on any of these drugs, your doctor probably won’t let you take tipranavir.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention the drugs in the IMPORTANT WARNING section as well as any of the following: boceprevir (no longer available in the United States; Victrelis); bosentan (Tracleer); antifungal drugs such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), or voriconazole (Vfend); felodipine, nicardipine, nisoldipine, or verapamil (Calan, Covera, Verelan, others); cholesterol-lowering drugs (‘statins’) such atorvastatin (Lipitor, in Caduet), rosuvastatin (Crestor), clarithromycin (Biaxin, in Prevpac); calcium-channel blockers like diltiazem (Cardizem, Cart Fluticasone (Flonase, Flovent, in Advair, in Dymista); immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Astagraf, Envarsus XR, Prograf, among others); desipramine (Norpramin); disulfiram (Antabuse); oestrogen hormone replacement therapy; medications for erectile dysfunction like sildenafil (Viagra), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn); medications for seizures like carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, others); medications for diabetes like glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), piogli; There are several other HIV medications, such as abacavir (Ziagen, in Epzicom, in Trizivir), atazanavir (Reyataz, in Evotaz), dolutegravir (Tivicay, in Juluca), and enfuvirtide (Fuzeon); etravirine (Intelence); fosamprenavir (Lexiva), lopinavir (in Kaletra), ralte; Salmeterol (Serevent, in Advair); fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax); paroxetine (Brisdelle, Paxil, Pexeva); or sertraline (Zoloft); telaprevir (no longer sold in the United States; Incivek); and trazodone are examples of selective serotonin reuptake inhibitors (SS Tell your doctor about all of the medications you are taking, even any not on this list, since many other drugs may also interact with tipranavir. During your tipranavir therapy, make sure to see your doctor or pharmacist before starting any new medications. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Tipranavir should be taken two hours before or two hours after didanosine (Videx).
  • Take antacids either one hour prior to or two hours after taking tipranavir if you take them.
  • Inform your doctor if you have or have had had diabetes, high blood sugar, high blood cholesterol or triglycerides (blood fats), or a recurrent illness such pneumonia, shingles, mycobacterium avium, herpes, cytomegalovirus, or tuberculosis.
  • You should be aware that taking tipranavir can cause some people with diabetes to experience worsening of their condition. If you have diabetes, it’s crucial to closely monitor your blood sugar levels while taking tipranavir and contact your doctor if they become challenging to manage. To control your blood sugar, your doctor might need to adjust your diabetic prescription or prescribe a brand-new drug.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you become pregnant while taking tipranavir. If you have HIV or are taking tipranavir, you should not breastfeed.
  • You should be aware that tipranavir can make hormonal contraceptives less effective (birth control pills, patches, rings, and injections). While using tipranavir, you’ll need to utilise another method of birth control to avoid getting pregnant. While taking this drug, discuss alternate birth control options with your doctor.
  • Tell the doctor or dentist that you are taking tipranavir if you are having surgery, including dental surgery.
  • Plan to use protective clothing, sunglasses, and sunscreen in addition to avoiding needless or prolonged sun exposure. Your skin could become more susceptible to sunlight while using tipranavir.
  • You should be aware that your body fat may develop in new places or shift to others, including your stomach, breasts, and the back of your neck and upper shoulders (the “buffalo hump”). Your face, buttocks, arms, and legs could all experience a loss of body fat. If you observe any of these changes in your body fat, speak with your doctor.
  • Even if you do not already have diabetes, you should be aware that taking this drug may cause hyperglycemia (increases in blood sugar). If you have any of the following side effects while taking tipranavir: severe thirst, frequent urination, intense hunger, blurred vision, or weakness, call your doctor right away. Calling your doctor as soon as you experience any of these symptoms is crucial because untreated high blood sugar can result in the deadly disease known as ketoacidosis. If ketoacidosis is not treated right away, it could become life-threatening. Dry mouth, nausea, vomiting, shortness of breath, fruity-smelling breath, and diminished consciousness are all signs of ketoacidosis.
  • You should be aware that when you take HIV medicine, your immune system could become stronger and start to fight other infections that were already present in your body. You might begin to exhibit signs of those infections as a result of this. At any time during your tipranavir therapy, be sure to let your doctor know if you experience any new or worsening symptoms.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you remember, take the missed dose of ritonavir. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Tipranavir could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Diarrhea
  • Loss of weight
  • Headache
  • Abdominal pain

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of these signs or any of the ones detailed in the IMPORTANT WARNING section:

  • Fever, chills, cough, or other infection-related symptoms
  • Rash
  • Skin that is red, swollen, or peeling
  • Itching
  • Throat constriction
  • Breathing difficulty
  • Hands and feet experiencing numbness, discomfort, and weakness
  • Breathing or swallowing challenges
  • Joint or muscle discomfort or stiffness

Other adverse effects of tipranavir are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Place tipranavir capsules in the refrigerator in unopened bottles. Tipranavir capsules should be kept in unopened bottles at room temperature, away from sources of extreme heat and moisture (not in the bathroom). Tipranavir solution should be kept at room temperature. Avoid freezing or cooling tipranavir solution. Tipranavir should be used within 60 days after the date you open the bottle; otherwise, discard the leftover medication.

All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for toddlers to open. Always lock safety caps and put the medication in a secure spot right away that is up and away from where young children can access it and cannot access it, in order to prevent poisoning in young children.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s response to tipranavir, your doctor will request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aptivus®
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