WARNING

Apri, which is a combination of estrogen and progestin, is used primarily as a contraceptive. While effective for preventing pregnancy, it comes with some risks and potential side effects. Here are the main risks:

• Blood Clots: There’s an increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE), especially in women who smoke, are over 35, or have a history of clotting disorders.
• Heart Attack and Stroke: The risk is elevated for women with high blood pressure, certain pre-existing conditions, or those who smoke.
• Cancer Risks: Long-term use may slightly increase the risk of certain types of cancers, such as breast and cervical cancer.
• Liver Issues: Rarely, it can cause liver problems, including benign liver tumors.
• Mood Changes: Some women experience mood swings, depression, or changes in libido.
• Nausea and Vomiting: These are common side effects, particularly when starting the medication.

Always discuss your health history with a healthcare provider to evaluate whether Apri is suitable for you and to understand the full range of potential risks and benefits.

Why is this medication prescribed?

Apri, which contains estrogen and progestin, is primarily prescribed for:

• Contraception: To prevent pregnancy by inhibiting ovulation and altering the cervical mucus and uterine lining to make it difficult for sperm to reach the egg and for a fertilized egg to implant.
• Regulating Menstrual Cycles: To help manage irregular or heavy menstrual periods.
• Acne: Sometimes used to treat acne in women who also need contraception.
• Reducing Menstrual Pain: Can help reduce the symptoms associated with menstrual cramps (dysmenorrhea).

How should this medicine be used?

Apri should be used as follows:

• Starting the Pack: Begin taking Apri on the first day of your menstrual cycle or on the first Sunday after your period begins. Some guidelines allow you to start at any time, but using additional contraception (like condoms) for the first 7 days is recommended if you start outside the first day of your period.
• Daily Use: Take one pill daily at the same time each day. This helps maintain consistent hormone levels and maximizes effectiveness.
• Pill Pack Structure: The pack contains 21 active pills with hormones. The last 7 pills are inactive (placebo). During this time, you will typically have your menstrual period.
• Missed Pills: Take it as soon as you remember, even if it means taking two pills in one day. Continue taking the remaining pills as usual. If you miss two or more pills, take the most recent missed pill as soon as you remember and continue with the rest of the pack. Use additional contraception (like condoms) for the next 7 days. Consult your healthcare provider for guidance.
• Switching from Another Contraceptive: If you’re switching from another form of hormonal birth control, consult your provider about when to start Apri to ensure continuous contraceptive protection.
• Storing the Medication: Store the pills at room temperature, away from moisture and heat.

Always follow your healthcare provider’s instructions for personalized advice and consult them if you have any questions or concerns about missed doses or other issues.

Other uses for this medicine

In addition to its primary use as a contraceptive, Apri (estrogen and progestin) may be prescribed for:

• Menstrual Disorders: To help manage heavy or irregular menstrual bleeding.
• Acne: For women who also need contraception, it can be used to treat acne.
• Premenstrual Dysphoric Disorder (PMDD): To alleviate symptoms associated with PMDD.
• Endometriosis: Sometimes used to manage symptoms related to endometriosis.

What special precautions should I follow?

Special Precautions for Apri:

• Medical History: Inform your healthcare provider if you have a history of blood clots, stroke, heart attack, high blood pressure, liver disease, certain cancers, or if you smoke. These conditions can increase the risk of complications.
• Regular Check-Ups: Regular follow-up appointments with your healthcare provider are important to monitor your health and adjust the prescription as needed.
• Smoking: Smoking increases the risk of serious cardiovascular side effects. It’s particularly important to avoid smoking if you’re over 35 and using Apri.
• Blood Clot Risk: If you have a family history of blood clots or are at higher risk for them, discuss this with your provider. They might recommend additional precautions or alternative methods.
• Interactions: Some medications and supplements can interact with Apri, potentially reducing its effectiveness. Inform your provider about all medications and supplements you’re taking.
• Side Effects: Report any unusual symptoms or side effects, such as severe headaches, vision changes, or leg swelling, to your healthcare provider immediately.
• Pregnancy: Do not use Apri if you are pregnant or think you might be pregnant. If you miss a period and suspect pregnancy, consult your provider.
• Liver Health: If you have liver disease or experience symptoms such as jaundice (yellowing of the skin or eyes), notify your provider as it might be necessary to discontinue use.

Always follow your healthcare provider’s specific recommendations and consult them with any concerns or questions about using Apri.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Apri. However, maintaining a balanced diet and healthy lifestyle is beneficial. If you have any dietary concerns or specific conditions, discuss them with your healthcare provider for personalized advice.

What should I do if I forget a dose?

• Take it as soon as you remember, even if it means taking two pills in one day. Continue taking the remaining pills at the usual time.
• Take the most recent missed pill as soon as you remember, and discard any earlier missed pills.
• Use backup contraception (like condoms) for the next 7 days to ensure effective pregnancy prevention.
• Consult your healthcare provider for additional guidance and to determine if you need further action.

What side effects can this medication cause?

Apri, like other hormonal contraceptives, can cause a range of side effects. Some are common and may diminish over time, while others might require medical attention. Here are potential side effects:

Common Side Effects:

• Nausea: Some women experience mild nausea, especially when starting the pill.
• Breast Tenderness: Tender or swollen breasts may occur.
• Headaches: Hormonal changes can lead to headaches or migraines.
• Mood Changes: Some women report mood swings or changes in emotional well-being.
• Spotting or Light Bleeding: Irregular spotting or light bleeding between periods is common, especially in the first few months.
• Weight Changes: Weight gain or loss can occur, though it’s often minimal.

Less Common but Serious Side Effects:

• Blood Clots: Risk of deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke.
• High Blood Pressure: Hormonal changes can impact blood pressure.
• Liver Problems: Rare cases of liver disease or liver tumors.
• Severe Abdominal Pain: Could indicate serious conditions like liver disease or ectopic pregnancy.
• Vision Changes: Blurred vision or other visual disturbances may occur.
• Jaundice: Yellowing of the skin or eyes can indicate liver issues.
• Gallbladder Disease: Rare cases of gallbladder problems.
• Severe Allergic Reactions: Rash, itching, or swelling may occur.

If you experience any severe or persistent side effects, or if you have symptoms like severe headaches, vision changes, or pain in your legs or chest, contact your healthcare provider promptly. They can help determine whether Apri is suitable for you or if alternative options should be considered.

What should I know about storage and disposal of this medication?

Storage and Disposal of Apri:

• Storage: Store Apri at room temperature, typically between 68°F and 77°F (20°C to 25°C). Keep the medication in its original blister pack and protect it from moisture and heat. Avoid storing it in the bathroom or near sources of heat.
• Disposal: Unused Medication: If you have unused or expired Apri, do not flush it down the toilet or pour it down the drain. Instead, follow local guidelines for medication disposal, which may include drug take-back programs or specific disposal instructions from your pharmacist.

In case of emergency/overdose

• Seek Immediate Help: If you experience severe side effects or symptoms that could indicate a serious problem (e.g., chest pain, severe headaches, vision changes, sudden leg swelling, or difficulty breathing), seek immediate medical attention.
• Symptoms: An overdose of Apri is unlikely to be life-threatening, but it may cause nausea, vomiting, or unusual bleeding.
• Action: If you suspect an overdose, contact your healthcare provider or local poison control center for advice. They can guide you on any necessary steps.

What other information should I know?

• Regular Check-Ups: Regular visits to your healthcare provider are important to monitor for any side effects and to ensure that the contraceptive is working effectively.
• Interactions: Be aware of potential drug interactions with other medications or supplements you are taking. Inform your healthcare provider of all your current medications.
• Effectiveness: Apri is highly effective when used correctly, but no contraceptive method is 100% foolproof. Consider additional contraception methods if needed.
• Health Monitoring: Report any unusual symptoms or health changes to your healthcare provider, as they may need to adjust your treatment.

Always follow your healthcare provider’s instructions for using and managing Apri, and consult them with any questions or concerns regarding its use.