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Aprepitant/Fosaprepitant Injection

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Why is this medication prescribed?

Adults may experience nausea and vomiting within 24 hours or up to a few days after having specific cancer chemotherapy treatments. Aprepitant injection and fosaprepitant injection are used to treat this condition, along with other drugs. Children 6 months and older can also utilise the fosaprepitant injectable. The injections of aprepitant and fosaprepitant are not used to alleviate existing nausea and vomiting. Antiemetics are a group of drugs that includes aprepitant and fosaprepitant injections. They function by preventing the effects of neurokinin, a brain chemical that naturally induces nausea and vomiting.

How should this medicine be used?

Both aprepitant and fosaprepitant injections are available as liquid emulsions that must be mixed with fluids before being administered intravenously (into a vein) by a physician or nurse in a healthcare setting. On day 1 of a chemotherapy treatment cycle, aprepitant or fosaprepitant injection is typically administered as a single dose, ending around 30 minutes before chemotherapy begins. Oral aprepitant may also be administered on days 2 and 3 of the chemotherapy treatment cycle for adolescents, teenagers, and adults undergoing fosaprepitant with specific chemotherapy regimens.

An adverse reaction to an injection of aprepitant or fosaprepitant may occur during or immediately after the injection. If you have any of the following symptoms during or soon after receiving treatment, let your doctor know right away: swelling around your eyes, rash, hives, itching, redness, flushing, difficulty breathing or swallowing, feeling faint or dizzy, or a quick or pounding heartbeat. The infusion will likely be stopped by your doctor, who may also administer other medications to treat the reaction.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using aprepitant or fosaprepitant injection,

  • If you have any allergies, including those to any of the substances in aprepitant injection or fosaprepitant injection, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Informing your physician that you are taking pimozide (Orap). If you are taking this medicine, your doctor will probably advise you not to use aprepitant or fosaprepitant injection.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, herbal products, vitamins, and nutritional supplements you are now taking or intend to take. Any of the following should be mentioned: Several antifungal medications include itraconazole (Onmel, Sporanox) and ketoconazole; anticoagulants (sometimes known as “blood thinners”) like warfarin (Coumadin, Jantoven); benzodiazepines such alprazolam (Xanax), midazolam, and triazolam (Halcion); Carbamazepine (Tegretol, Teril, etc), certain cancer chemotherapy drugs as ifosfamide (Ifex), vinblastine (Velban), and vincristine (Marqibo); nefazodone, clarithromycin (Biaxin, in Prevpac), diltiazem (Cardizem, Cartia, Diltzac, and others), certain HIV protease inhibitors like nelfinavir (Viracept) and ritonavir (Norvir, in Kaletra, Technivie, and Viekira Pak), steroids such dexamethasone and methylpredni (Rifadin, Rimactane, in Rifamate, Rifater). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Aprepitant and fosaprepitant may also interact with many other drugs, so be sure to let your doctor know about all the drugs you’re taking—even those not on this list.
  • If you have liver illness now or ever had it, let your doctor know.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. In order to prevent pregnancy while taking aprepitant or fosaprepitant, as well as for one month after your last dose, if you are using hormonal contraceptives (birth control pills, patches, rings, implants, or injections) during treatment, you should also use a second nonhormonal method of birth control (spermicide, condom). Discuss effective birth control options with your doctor. Call your doctor if you become pregnant while taking aprepitant or a fosaprepitant injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects are possible with both aprepitant and fosaprepitant injections. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Weakness or fatigue
  • Diarrhea
  • Pain, swelling, redness, itchiness, or hardness at the injection site
  • Arms or legs experiencing weakness, numbness, tingling, or discomfort
  • Headache
  • Heartburn

Some adverse effects can be very harmful. Stop using aprepitant or fosaprepitant, call your doctor right away, or seek emergency medical attention if you have any of the following symptoms:

  • Skin that is flaking or blistering
  • Urination that is unpleasant or frequent, or an urgent urge to urinate

There may be other adverse effects from aprepitant and fosaprepitant. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What other information should I know?

Keep all of your doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cinvanti®
  • Emend®
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