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Apidra (Generic Insulin Glulisine (rDNA origin) Injection)

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Why is this medication prescribed?

Diabetes type 1 is managed with insulin glulisine (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat persons with type 2 diabetes, a condition in which the blood sugar levels are out of control because the body does not generate enough or use insulin as it should. In people with type 1 diabetes, insulin glulisine is often administered along with another form of insulin, unless an external insulin pump is being used. In those with type 2 diabetes, insulin glulisine may also be used with another kind of insulin or with diabetes oral medication(s). Insulin glulisine is a synthetic, short-acting substitute for human insulin. Insulin glulisine functions by supplanting the insulin that the body typically produces and by assisting in the transfer of blood sugar to different bodily tissues where it is utilised as an energy source. The liver’s ability to produce additional sugar is likewise inhibited.

People with diabetes and high blood sugar over time may experience serious or fatal complications, such as heart disease, stroke, kidney issues, nerve damage, and vision issues. It may be possible to control your diabetes and enhance your health by using medication(s), making lifestyle changes (such as diet, exercise, and quitting smoking), and routinely checking your blood sugar. This treatment may also lower your risk of heart attack, stroke, kidney failure, nerve damage (resulting in numb, cold legs or feet and diminished sex capacity in both men and women), eye issues, such as changes in eyesight or blindness, or gum disease, which are all symptoms of diabetes. The optimal strategy to manage your diabetes will be discussed with you by your doctor and other healthcare professionals.

How should this medicine be used?

A solution (liquid) form of insulin glulisine is available for subcutaneous injection (under the skin). It is often injected up to 15 minutes prior to eating or 20 minutes after a meal has begun. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the directions on your insulin glulisine exactly. Use it only as directed by your doctor, neither more nor less often.

Never administer insulin glulisine if you are experiencing hypoglycemia (low blood sugar) symptoms or if your blood sugar level is low. Injecting insulin into red, puffy, itchy, or thickened skin is not advised.

Diabetes cannot be cured, although insulin glulisine can regulate it. Even if you feel well, keep taking insulin glulisine. Without consulting your doctor, never discontinue taking insulin glulisine. Without consulting your doctor, never switch to a different brand or type of insulin or alter the dosage of any type of insulin you are now on. To ensure that you obtained the correct type of insulin from the pharmacy, always check the label on the insulin bottle.

Insulin glulisine is sold in vials and dosage pens that include medicine cartridges within. Make sure you are aware of the sort of container your insulin glulisine comes in as well as any additional equipment you will require to inject your prescription, such as needles, syringes, or pens.

You will need syringes to administer your dose if your insulin glulisine is supplied in vials. Request instruction on using a syringe to administer insulin glulisine from your physician or pharmacist. If you have any concerns about the kind of syringe you ought to use, consult your physician or pharmacist.

Make sure to read and comprehend the manufacturer’s instructions if your insulin glargine is provided in pens. You can get the pen’s instructions from your doctor or pharmacist. Always carry out the safety test before use, and pay close attention to the instructions.

Never share needles, syringes, or pens, and never reuse needles or syringes. Always take out the needle from an insulin pen as soon as you’ve finished injecting your dose. Put needles and syringes in a container that won’t puncture. For disposal instructions on the puncture-resistant container, consult your doctor or pharmacist.

You can be instructed by your doctor to combine your insulin glulisine with NPH insulin (Novolin N, Humulin N) in the same syringe. Insulin glulisine should not be combined or diluted with any other form of insulin. When combining insulin glulisine and NPH insulin, pull the insulin glulisine into the syringe first, followed by the NPH insulin, and inject the mixture right away.

Glulisine insulin injection sites include the upper arms, stomach, and thighs. Never administer insulin glulisine into a muscle or vein. With each dose, switch (rotate) the injection site within the targeted area; avoid using the same location more frequently than once every one to two weeks.

Before injecting your insulin, always check the level on the bottle. It need to be transparent and colourless. If your insulin glulisine is coloured, hazy, includes solid particles, or has beyond its expiration date, do not use it.

Additionally, an external insulin pump can be used with insulin glulisine. Check the pump label to verify sure the pump can be utilised for continuous fast-acting insulin delivery before utilising insulin glulisine in a pump system. Ask your doctor or pharmacist to demonstrate how to use the insulin pump, and read the pump manual for information on suggested reservoir and tube settings. When using insulin glulisine in an external insulin pump, do not dilute it or combine it with any other kind of insulin. Your stomach area should get injections of the insulin glulisine utilised in an external insulin pump. Replace the insulin in the reservoir, as well as the tubing, needle, and infusion site (the location where the pump is connected to the body), every 48 hours or less when utilising insulin glulisine in an external insulin pump. Use an alternative infusion site and notify your doctor if the infusion site is red, itching, or thickened.

High blood sugar can happen quickly when using insulin glulisine in an external insulin pump if the pump malfunctions, the insulin in the reservoir is exposed to direct sunlight, or the temperature rises above 98.6°F (37°C). If the tube leaks, kinks, blocks, disconnects, or becomes detached, high blood sugar may also result. If you have high blood sugar, the pump alarm goes off, or the insulin flow is interrupted, you might need to change the infusion set and insulin in the pump or infusion site. Call your doctor right away if the issue cannot be identified and fixed straight away. It’s possible that you’ll need to utilise insulin subcutaneously for a while (using syringes or an insulin pen). Ensure you have extra insulin on hand, as well as any other tools or supplies, and ask your doctor or pharmacist to demonstrate how to use them.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using insulin glulisine,

  • Inform your doctor and pharmacist if you have any allergies to any other medicines, insulin (Humulin, Novolin, and other brands), or any of the components in insulin glulisine. For a list of the ingredients, consult your pharmacist or the manufacturer’s patient information.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik) are examples of angiotensin-converting enzyme (ACE) inhibitors. Benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril; atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal) are examples of beta blockers. Fenofibrate (Antara, Lofibra, TriCor, Triglide), gemfibrozil (Lopid), and niacin (Niacor, Niaspan, in Advicor), as well as clonidine (Catapres, Catapres-TTS, in Clorpres), danazol, disopyramide (Norpace), diuretics (‘water pills,’ such as Prozac and Sarafem), drugs to treat colds and asthma; some HIV drugs such as amprenavir (Agenerase), atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (in Kaletra, Norvir), saquinavir (Invirase), monoamine oxidase (MAO) inhibitors as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); drugs for nausea and mental illness; oral diabetes medications; oral steroids like dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); pentamidine (NebuPent, Pentam); pentoxifylline (Pentoxil, Trental); pramlintide (Symlin); hormonal contraceptives (birth control pills, patches, rings, injections, or implants); aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic) are examples of salicylate painkillers. Other examples include somatropin (Nutropin, Serostem, among others), sulfa antibiotics, Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you now have or have ever had nerve damage brought on by diabetes or any other illnesses, such as kidney or liver disease.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while using insulin glulisine.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are using insulin glulisine.
  • Alcohol may alter blood sugar levels. Inquire with your doctor about whether drinking alcohol is safe while taking insulin glulisine.
  • In the event that you become ill, encounter exceptional stress, or alter your exercise and activity level, consult your doctor for advice. Your blood sugar levels and possible insulin requirements may fluctuate as a result of these changes.
  • Find out from your doctor how frequently you should test your blood sugar. Be mindful that hypoglycemia can impair your ability to do activities like driving, and ask your doctor if you should check your blood sugar before operating machinery or driving.

What special dietary instructions should I follow?

Make sure to abide by all dietary and exercise advice given to you by your physician or nutritionist. It is crucial to follow a healthy diet and eat around the same portions of the same foods at roughly the same times every day. Your ability to control your blood sugar levels may suffer if you skip or delay meals, change the quantity or type of food you eat, or all three.

What should I do if I forget a dose?

It is necessary to provide insulin glulisine intravenously up to 15 minutes before or within 20 minutes of beginning a meal. If it has been some time since your last meal, call your doctor to inquire about whether you should inject the missed dose or follow your doctor’s advice. To make up for a missing dose, do not provide a second injection.

What side effects can this medication cause?

Your blood sugar levels could alter if you use insulin glulisine. You should be aware of the signs of low and high blood sugar as well as what to do if you experience these signs.

Side effects are possible with insulin glulisine. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Itching, swelling, or redness at the injection site
  • Skin changes, skin thickening (due to fat buildup), or a small depression in the skin (fat breakdown)
  • The hands and feet swelling
  • Gaining weight
  • Constipation

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Itching or rashes all over the body
  • Breathing difficulty
  • Wheezing
  • Dizziness
  • Distorted vision
  • Rapid heart rate
  • Sweating
  • Lightheadedness/fainting
  • Breathing or swallowing issues
  • Weakness
  • Muscle pain
  • Irregular heartbeat

Glulisine insulin may also have additional adverse effects. If you experience any strange issues while taking this drug, call your doctor right away.

What should I know about storage and disposal of this medication?

Insulin glulisine vials and pens should be kept in the refrigerator out of the direction of light. Never let insulin glulisine freeze, and never use it after it has frozen and thawed. Vials of unopened insulin glulisine may be kept for up to 28 days in the refrigerator or at room temperature, away from heat and sunlight. Unused prefilled pens can be kept chilled or kept at room temperature for up to 28 days if they are kept out of the sun and heat. After usage, prefilled pens shouldn’t be kept in the refrigerator; instead, they should be kept at room temperature for up to 28 days. After 28 days, throw away opened insulin glulisine vials and pens. Once the refrigerated insulin glulisine’s expiration date has past, discard the unopened container. Any insulin glulisine that has been frozen or subjected to high heat should be disposed away.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Insulin glulisine overload can happen if you use too much of it, the proper dosage, but consume less food than normal or exercise more than usual. Hypoglycemia may result from an overdose of insulin glulisine. Follow your doctor’s recommendations on what to do if you experience hypoglycemia if you have symptoms. Additional signs of an overdose could include:

  • Consciousness loss
  • Seizures

What other information should I know?

Keep all of your appointments with your physician and the lab. You should monitor your blood sugar and glycosylated haemoglobin (HbA1c) frequently to see how well you’re responding to insulin glulisine. Your doctor will also instruct you on how to measure your blood sugar levels at home in order to monitor your reaction to insulin. Pay close attention to these directions.

Wearing a diabetes identity bracelet will ensure that you receive the right care in an emergency.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Apidra®
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