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Anzemet Injection (Generic Dolasetron Injection)

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Why is this medication prescribed?

An injection of dolasetron is used to both prevent and treat post-operative nausea and vomiting. Injections of dolasetron shouldn’t be used to treat or prevent nausea and vomiting in cancer chemotherapy patients. Dolasetron belongs to the group of drugs known as serotonin 5-HT3 receptor antagonists. It functions by preventing the effects of serotonin, a naturally occurring chemical that can result in nausea and vomiting.

How should this medicine be used?

Dolasetron injection is administered by a medical professional in a hospital or clinic as a solution (liquid) that is injected intravenously (into a vein). Typically, it is injected once right before surgery concludes or as soon as nausea or vomiting set in.

For oral administration to youngsters, dolasetron injection can be blended with apple or apple-grape juice. It is often administered two hours prior to surgery. Despite being able to be stored at room temperature, this mixture must be used within two hours of mixing.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using dolasetron injection,

  • If you have an allergy to dolasetron, any other drugs, or any of the ingredients in dolasetron injection, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, herbal products, vitamins, and nutritional supplements you are now taking or intend to take. Any of the following should be mentioned: cimetidine, diuretics (often known as “water pills”), fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys), lithium (Lithobid), blood pressure-lowering drugs, atenolol (Tenormin, in Tenoretic), flecainide, quinidine (in Nuedexta), and verapamil (Calan, Covera, in Tarka); methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications to treat migraines such as almotriptan (Axert), eletrip, selective serotonin reuptake inhibitors (SSRIs) as fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rifampin (Rif (Conzip, Ultram, in Ultracet). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
  • Inform your doctor if you or anyone in your family has or has ever had long QT syndrome, another irregular heartbeat or heart rhythm issue, low blood levels of potassium or magnesium, heart failure, or kidney disease. Long QT syndrome increases the risk of developing an irregular heartbeat that may cause fainting or sudden death.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The injection of dolasetron may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Drowsiness
  • Chills

Some adverse effects can be very harmful. Call your doctor right away if you develop any of these symptoms, or go to the hospital for emergency care:

  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Alterations in cardiac rhythm or heartbeat
  • Dizziness fainting, dizziness, or trembling
  • Irregular, fast, or sluggish heartbeat
  • Agitation
  • Confusion
  • Diarrhoea, vomiting, or nauseous
  • Inability to coordinate
  • Twitching or stiff muscles
  • Seizures
  • Coma (loss of consciousness)

Other negative effects from dolasetron injection could also occur. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Dizziness
  • Fainting
  • Irregular, hammering, or quick heartbeat

What other information should I know?

Keep all of your doctor’s appointments.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Anzemet® Injection
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