A specific type of non-small cell lung cancer (NSCLC) that has migrated to other organs, cannot be surgically removed, and has gotten worse during or after receiving platinum chemotherapy drugs is treated with amivantamab-vmjw injection. The drug amivantamab-vmjw injection belongs to a group of drugs known as bispecific antibodies. It functions by assisting your immune system in reducing or halting the spread of cancer cells.

In a hospital or infusion centre, a doctor or nurse will slowly inject amivantamab-vmjw injection into a vein using a solution (liquid). Initially, it is typically administered once daily for two consecutive days. For the duration of your therapy, it is typically administered once every two weeks after the initial two doses. How well your body responds to the drug and any side effects you experience will determine how long your therapy will last.

Both during and after the infusion, a doctor or nurse will keep a close eye on you to make sure you are not having a severe reaction to the medication. To assist stop adverse reactions to amivantamab-vmjw, different drugs may be prescribed to you. If you suffer any of the following during the infusion, let your doctor or nurse know right away: nausea, shortness of breath, fever, chills, flushing, chest pain, lightheadedness, nausea, or vomiting.

If you suffer specific adverse effects, your doctor may need to reduce the rate of your infusion or discontinue your therapy altogether. Discuss your feelings before, during, and following therapy with your doctor.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving amivantamab-vmjw injection,

• If you have an allergy to amivantamab-vmjw, any other drugs, or any of the ingredients in amivantamab-vmjw injection, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• If you have breathing issues or have ever had a lung disease other than lung cancer, let your doctor know.
• If you are pregnant or want to become pregnant, let your doctor know. Pregnancy should not occur while a patient is getting amivantamab-vmjw injection. A pregnancy test is required before you start taking this medicine. Use reliable birth control during your amivantamab-vmjw injectable treatment and for three months after your last dosage. Call your doctor if you get pregnant while getting amivantamab-vmjw injection. Injecting amivantamab-vmjw may be harmful to the foetus.
• Inform your doctor if you are nursing a child. Your doctor will advise you to stop breastfeeding for three months following your final dose of amivantamab-vmjw injection as well as throughout therapy.
• Amivantamab-vmjw may produce skin responses, some of which may be severe, so you should be aware of that. During your treatment with amivantamab-vmjw injection and for two months following your final dosage, you should make a strategy to prevent unnecessary or prolonged sun exposure and to wear protective clothes, sunglasses, and sunscreen. If your skin starts to feel dry or irritated, your doctor could advise you to use an alcohol-free moisturiser. Call your doctor right away if you have any of the following symptoms: skin that is blistering, peeling, or shedding, itchy, dry or cracked, or rashes

Keep eating normally unless your doctor instructs you otherwise.

Side effects from amivantamab-vmjw are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Changes in the fingernails or toenails, swelling, or pain
• Unusual weakness or fatigue
• Increasing facial, lip, or ocular swelling
• Hands, foot, ankles, or lower legs swelling
• Back, neck, shoulder, arm, or muscle pain
• Oral sores
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal pain
• Diminished appetite
• Arms or legs numb, tingly, painful, or scorching
• Headache
• Dizziness

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section:

• Chest pain, fever, shortness of breath, or a new or worsening cough
• Eye discomfort
• Eyes that are uncomfortable, itchy, red, teary, or dry
• Distorted vision
• Vision alters
• Eyes’ sensitivity to light
• Simple bleeding or bruises
• Bleeding from the nose or gums
• Blood in the faeces or urine
• Exhaling blood

There may be other negative effects from amivantamab-vmjw. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. Before you start your therapy, your doctor will run a lab test to determine whether amivantamab-vmjw can treat your cancer. Your doctor will prescribe certain lab tests throughout your therapy to monitor how your body is responding to amivantamab-vmjw.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.