Why is this medication prescribed

Amivantamab-vmjw injection is prescribed to treat non-small cell lung cancer (NSCLC) that has specific genetic mutations in the epidermal growth factor receptor (EGFR) gene. It’s used for patients whose cancer has progressed during or after platinum-based chemotherapy. Amivantamab-vmjw is a monoclonal antibody that targets and binds to the EGFR and MET receptors on cancer cells, helping the immune system to attack and kill these cells.

How should this medicine be used?

Amivantamab-vmjw is an intravenous (IV) infusion used for the treatment of certain types of non-small cell lung cancer (NSCLC) with specific genetic mutations (e.g., EGFR exon 20 insertion mutations). Here are the general guidelines on its use:

• Administration: Amivantamab-vmjw is administered as an IV infusion by a healthcare professional, usually in a clinical setting such as a hospital or infusion center. The infusion is given slowly over a few hours, especially during the initial doses, to monitor for any infusion-related reactions.
• Dosage: The dosing schedule typically involves an initial loading period, where the drug is given once weekly for the first four weeks. After the initial four weeks, the infusion is usually given once every two weeks. The dosage amount is based on the patient’s body weight and other factors determined by the healthcare provider.
• Pre-medications: To reduce the risk of infusion-related reactions, patients may be given pre-medications like antihistamines, corticosteroids, and antipyretics (e.g., acetaminophen) before the infusion.
• Monitoring: Patients should be monitored closely during and after the infusion for any signs of infusion-related reactions, such as fever, chills, nausea, or difficulty breathing. Regular monitoring of skin reactions, eye problems, and lung function is also necessary due to the potential side effects.
• Treatment Duration: The duration of treatment depends on the patient’s response to the therapy, tolerance, and overall health condition. The healthcare provider will determine how long the treatment should continue.

If you have any specific concerns or questions about using Amivantamab-vmjw, it’s always best to consult with your healthcare provider.

Other uses for this medicine

Amivantamab-vmjw is approved specifically for the treatment of non-small cell lung cancer (NSCLC) with specific EGFR exon 20 insertion mutations. There are no widely recognized alternative uses outside of this indication.

What special precautions should I follow?

Special Precautions for Amivantamab-vmjw Injection:

• Allergic Reactions and Infusion-Related Reactions: Be aware of potential infusion-related reactions. Signs include fever, chills, nausea, rash, shortness of breath, and low blood pressure. Always receive the infusion in a setting where immediate medical help is available. Pre-medications, such as antihistamines or steroids, may be prescribed to reduce these risks. Make sure to take them as directed.
• Monitor for Skin Reactions: This medication can cause severe skin reactions, such as rash, itching, and dry skin. Report any new or worsening skin symptoms to your healthcare provider immediately. Regular use of moisturizers and avoiding direct sunlight can help manage and prevent skin problems.
• Eye Precautions: Amivantamab can cause eye problems, including dryness, blurred vision, or inflammation. Inform your healthcare provider if you experience any eye symptoms. Use artificial tears or lubricating eye ointments as recommended.
• Monitor for Lung Issues: There is a risk of developing interstitial lung disease (ILD) or pneumonitis. Symptoms include new or worsening cough, shortness of breath, or chest pain. Seek immediate medical attention if these symptoms occur.
• Pregnancy and Breastfeeding: Amivantamab-vmjw may harm an unborn baby. Use effective contraception during treatment and for at least 3 months after the last dose if you are of childbearing potential. Do not breastfeed during treatment and for 3 months after the last dose.
• Kidney and Liver Function: Inform your healthcare provider of any existing kidney or liver problems, as adjustments in monitoring or dosing may be needed.
• Pre-existing Medical Conditions: Disclose all pre-existing medical conditions, especially any history of lung disease, heart conditions, or skin disorders.
• Drug Interactions: Provide a complete list of all medications, including prescription, over-the-counter drugs, vitamins, and herbal supplements, to avoid potential drug interactions.

If you experience any severe or persistent symptoms, it’s important to contact your healthcare provider. They can help determine if you should continue the medication or if another treatment might be more appropriate.

What special dietary instructions should I follow?

• No Specific Dietary Restrictions: There are no specific dietary restrictions associated with Amivantamab-vmjw. However, maintaining a balanced diet and staying hydrated may help your body cope better with cancer treatment.
• Stay Hydrated: Drink plenty of water, especially if you experience side effects like nausea or diarrhea.

What should I do if I forget a dose?

If you miss a scheduled dose, contact your healthcare provider as soon as possible. They will provide instructions on how to reschedule the infusion. Do not attempt to make up for the missed dose on your own.

What side effects can this medication cause?

Amivantamab-vmjw Injection can cause a range of side effects, from mild to severe. It is important to be aware of these potential side effects so that you can recognize and report them promptly to your healthcare provider.

Common Side Effects:

• Skin Reactions: Rash (including acneiform rash) is very common and may appear on the face, chest, back, or other parts of the body. Dry skin, itching (pruritus), or skin peeling. Hyperpigmentation or discoloration of the skin.
• Infusion-Related Reactions: Fever, chills, nausea, vomiting, dizziness, shortness of breath, or low blood pressure during or shortly after the infusion. These are most likely to occur during the first infusion and may require stopping the infusion and administering medications to manage symptoms.
• Eye Problems: Dry eyes, blurred vision, or eye inflammation (conjunctivitis). Eye pain or redness.
• Nail Problems: Nail disorders such as inflammation around the nail bed (paronychia), brittle nails, or other changes in the nails.
• Gastrointestinal Issues: Nausea, vomiting, diarrhea, or constipation. Loss of appetite or weight loss.
• Muscle and Joint Pain: Pain in the muscles, joints, or bones (myalgia, arthralgia).
• Fatigue: Feeling tired or weak is a common side effect that may affect daily activities.
• Swelling (Edema): Swelling of the hands, feet, or ankles (peripheral edema).

Serious Side Effects:

• Lung Problems: Interstitial lung disease (ILD) or pneumonitis, which can be life-threatening. Symptoms include new or worsening cough, shortness of breath, or chest pain. Immediate medical attention is necessary if these symptoms occur.
• Severe Skin Reactions: Severe rash, skin peeling, blistering, or symptoms that resemble a severe allergic reaction.
• Severe Eye Problems: Inflammation of the cornea (keratitis) or ulceration can cause severe pain, redness, sensitivity to light, and blurred vision.
• Liver Problems: Elevated liver enzymes in blood tests, which may indicate liver damage. Symptoms include yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain.
• Heart Problems: There may be a risk of heart rhythm problems, particularly in those with a history of heart disease.
• Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, which require immediate medical attention.
• Blood Disorders: Low white blood cell counts, which can increase the risk of infections.

Amivantamab-vmjw may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Amivantamab-vmjw Injection:

• Storage:
  • Amivantamab-vmjw should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). It should not be frozen. Protect it from light by keeping it in its original packaging until ready for use.
  • You are unlikely to have Amivantamab-vmjw at home, as it is administered by healthcare professionals in a clinical setting. However, if you are storing it temporarily (e.g., during transport to the infusion center), keep it in a cooler bag with ice packs, ensuring it stays at the correct temperature.
• Disposal:
  • Follow local guidelines for the disposal of biologic medications and any medical waste associated with the administration (e.g., syringes, needles, infusion bags).
  • Do not attempt to dispose of any leftover medication yourself. If you have concerns or find yourself in possession of Amivantamab-vmjw, contact your healthcare provider or a local disposal program.

In case of emergency/overdose

If you experience symptoms such as difficulty breathing, swelling of the face or throat, severe rash, or chest pain during or after the infusion, seek emergency medical help immediately. These could be signs of a severe allergic or infusion-related reaction.

Overdose of Amivantamab-vmjw is unlikely, as it is administered by a healthcare professional. However, if an overdose is suspected (e.g., due to an administration error), the healthcare team will monitor the patient closely for signs of toxicity and provide appropriate supportive care.

In the event of any serious or life-threatening symptoms, call emergency services (e.g., 911) or go to the nearest emergency room.

What other information should I know?

• Regular Monitoring: Keep all appointments with your healthcare provider for regular monitoring, including blood tests, scans, and physical exams, to assess how well the treatment is working and to monitor for side effects.
• Avoid Certain Activities: Depending on how you feel, you may need to avoid activities that require alertness, such as driving or operating machinery, especially if you experience side effects like fatigue or blurred vision.
• Medical Identification: Consider wearing a medical alert bracelet or carrying an ID card indicating that you are receiving Amivantamab-vmjw, especially if you have a history of severe allergic reactions or other serious side effects.
• Stay Informed: Be proactive in asking your healthcare provider questions about your treatment plan, potential side effects, and any other concerns you may have.
• Communication with Other Healthcare Providers: Inform any other healthcare providers, including dentists, that you are receiving Amivantamab-vmjw before undergoing any new medical or dental procedures.

If you have any specific questions or concerns about using Amoxicillin, don’t hesitate to consult your healthcare provider for personalized advice.