Patients who have low potassium levels in their bodies or for whom low potassium levels in the body could be harmful are treated for high blood pressure and heart failure with the combination of amiloride and hydrochlorothiazide, either alone or in combination with other drugs. Amiloride and hydrochlorothiazide are both members of the diuretic (sometimes known as “water pills”) drug class. They function by forcing the kidneys to excrete salt and water from the body through the urine.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

The oral tablet containing amiloride and hydrochlorothiazide is available. It is typically taken in the morning with breakfast once a day. Take amiloride and hydrochlorothiazide at roughly the same time each day to help you remember to take them. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take hydrochlorothiazide and amiloride exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Despite not curing heart failure or high blood pressure, this medicine manages their symptoms. Even if you feel better, keep taking amiloride and hydrochlorothiazide. Never stop taking hydrochlorothiazide and amiloride without consulting a doctor.

Ask your doctor or pharmacist for more details if you’re interested in using this medication for any other conditions.

Before taking amiloride and hydrochlorothiazide,

• If you have any allergies to amiloride, hydrochlorothiazide, sulfonamide-containing drugs, any other drugs, or any of the substances in amiloride and hydrochlorothiazide tablets, let your doctor and pharmacist know right once. For a list of the ingredients, consult the patient information or speak with your pharmacist.
• If you are using spironolactone (Aldactone, in Aldactazide), other triamterene-containing drugs, potassium supplements, or potassium-containing pharmaceutical supplements, you should not take amiloride with hydrochlorothiazide.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Benazepril, captopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril are examples of angiotensin-converting enzyme (ACE) inhibitors. Benazepril is found in Lotrel, Capoten, and Lotrel, while ramipril is found in Altace and trandolapril is found in Mavik;angiotensin II receptor antagonists (ARB), such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Teveten HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor), barbiturates such phenobarbital and secobarbital (Seconal); corticosteroids like fludrocortisone, betamethasone, budesonide, cortisone, and others; and phenobarbital (Floriner), prednisone (Rayos), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol), corticotropin (ACTH H.P., Acthar Gel), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), insulin and oral diabetes medications, lithium (Lithobid), medications for high blood pressure, or nonsteroidal anti-inflammatory drugs (NSAIDs) like (Astagraf XL, Prograf). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Take cholestyramine or colestipol an hour before or four hours after taking amiloride and hydrochlorothiazide if you’re taking either of those medications.
• In case you have kidney illness, let your doctor know. Your physician might advise against using hydrochlorothiazide plus amiloride.
• If you have diabetes, gout, or liver disease, let your doctor know.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you get pregnant while taking hydrochlorothiazide and amiloride.
• Inform your doctor or dentist that you are taking amiloride and hydrochlorothiazide if you are having surgery, including dental surgery.
• You should be aware that taking amiloride or hydrochlorothiazide together may increase your risk of fainting if you stand up too quickly after lying down. This is more typical when you initially start taking hydrochlorothiazide and amiloride. Get out of bed gradually, resting your feet on the floor for a few minutes before standing up, to avoid this issue. These negative effects may be exacerbated by alcohol.

Follow these guidelines carefully if your doctor advises you to eat or drink more potassium-rich foods (such as bananas, prunes, raisins, and orange juice) or to follow a low-salt or low-sodium diet.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Hydrochlorothiazide with amiloride may have negative side effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

1. Uneasy stomach
2. Diarrhea
3. Reduced appetite
4. Abdominal pain
5. Gas
6. Headache

Call your doctor right away if you develop any of these symptoms, or go to the hospital for emergency care:

1. Dry lips, thirst, nausea, vomiting, fatigue, restlessness, confusion, muscle weakness, soreness, or cramps, a rapid heartbeat, and other symptoms of electrolyte imbalance and dehydration
2. Irregular or slow heartbeat
3. Uncommon bruising or bleeding
4. The skin or eyes turning yellow
5. Rash
6. Hives
7. Itching
8. Breathing or swallowing challenges

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. Blood tests should be performed occasionally, and your blood pressure should be checked often.

Inform the lab staff and your doctor that you are taking amiloride and hydrochlorothiazide prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.