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Aloxi (Generic Palonosetron Injection)

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Why is this medication prescribed?

Injections of palonosetron are used to stop nausea and vomiting that may happen within 24 hours of cancer chemotherapy or surgery. Additionally, it is used to stop delayed nausea and vomiting that may happen several days after taking specific chemotherapy drugs. The drug palonosetron injection belongs to a group of drugs known as 5-HT3 receptor antagonists. It functions by preventing the effects of serotonin, a naturally occurring chemical that can result in nausea and vomiting.

How should this medicine be used?

The injection of palonosetron is administered intravenously (into a vein) by a medical professional in a hospital or clinic. Palonosetron is typically administered as a single dose around 30 minutes prior to the start of chemotherapy when used to reduce nausea and vomiting brought on by chemotherapy. Palonosetron may be administered before each cycle of treatment if you are undergoing more than one course of chemotherapy. Palonosetron is typically administered as a single dose right before surgery to avoid nausea and vomiting brought on by the procedure.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving palonosetron injection,

  • Inform your doctor and pharmacist if you have any allergies to any medications, including ondansetron (Zofran), alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), or any of the constituents in palonosetron injection. For a list of the ingredients, consult your pharmacist or the manufacturer’s patient information.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Incorporate any of the following: lithium (Lithobid), fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys), migraine medications like almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), monoamine oxidase (MAO) inhibitors like isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); selective serotonin reuptake inhibitors (SSRIs) like citalopram (Celexa), escitalopram (Lex (Conzip, Ultram, in Ultracet). Your physician might need to adjust the dosage of your drugs or keep a closer eye on you for adverse effects.
  • Inform your doctor of any medical conditions you now have or have ever had.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while having palonosetron injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from palonosetron injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Constipation
  • Redness, swelling, or discomfort at the injection site

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Chest pain
  • The facial swelling
  • Alterations in cardiac rhythm or heartbeat
  • Unsteadiness or faintness
  • Fainting
  • Irregular, fast, or sluggish heartbeat
  • Agitation
  • Confusion
  • Diarrhoea, vomiting, and nauseous
  • Inability to coordinate
  • Twitching or stiff muscles
  • Seizures
  • Coma (loss of consciousness)

 

Other negative effects from palonosetron injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Seizures
  • Fainting
  • Having trouble breathing
  • Pale or blue skin tone

What other information should I know?

Keep all of your doctor’s appointments.

Any queries you may have regarding your medicine, ask your doctor.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aloxi®
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