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Alosetron

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WARNING

Alosetron may have severe GI (GI; affecting the stomach or intestines) side effects, such as ischemic colitis (reduced blood supply to the bowels) and extreme constipation, which may require hospital treatment and, in rare cases, result in death. If you are taking any of the following medications, let your doctor know: drugs to treat asthma, diarrhoea, lung disease, mental illness, motion sickness, overactive bladder, pain, Parkinson’s disease, stomach or intestinal cramps, ulcers, and upset stomach. antihistamines; some antidepressants (‘mood elevators’) known as tricyclic antidepressants. Inform your physician if you have constipation right now, frequently, or if it has ever caused you issues. Tell your doctor if you also have a bowel obstruction, ischemic colitis, blood clots, or any condition that causes inflammation of the bowels, such as Crohn’s disease (which causes swelling of the digestive tract’s lining), ulcerative colitis (which causes swelling and sores in the lining of the colon [large intestine] and rectum), diverticulitis (which causes small pouches in the lining of the large intestine to become inflam Most likely, your doctor will advise against taking alosetron.

If you suffer any of the following signs: constipation, new or worsening stomach pain, or blood in your stools, stop taking alosetron and contact your doctor right away. If your constipation does not improve after you stop using alosetron, make another appointment with your doctor. If these symptoms caused you to stop taking alosetron, do not start it again unless your doctor instructs you to.

Alosetron can only be prescribed by a select group of medical professionals who are registered with the manufacturer of the drug and who are aware of its potential negative effects. Before you start taking alosetron, your doctor will give you a copy of the manufacturer’s patient information leaflet (Medication Guide), and your pharmacist will give you a copy each time you get your prescription filled. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

The dangers of using alosetron should be discussed with your doctor.

Why is this medication prescribed?

Irritable bowel syndrome (IBS), a condition that causes stomach pain, bloating, constipation, and diarrhoea, is used to treat diarrhoea, pain, cramps, and the feeling of an urgent need to have bowel movements in women who have diarrhoea as their primary symptom and have not responded to other treatments. Alosetron belongs to a group of drugs known as 5-HT3 receptor antagonists. Alosetron functions by delaying the passage of faeces through the intestines.

How should this medicine be used?

Alosetron is available as an oral tablet. Typically, it is taken twice daily, with or without food. Alosetron should be taken at roughly the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Alosetron should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

You’ll likely begin taking alosetron at a low dose prescribed by your doctor. After you’ve been taking the low dose for 4 weeks, your doctor will want to speak with you. Your doctor may increase your dose if your symptoms are not under control but you are not experiencing any severe side effects from alosetron. Alosetron is unlikely to be of assistance if you take the increased dose for 4 weeks and your symptoms are still not under control. Call your doctor and stop taking alosetron.

IBS may be managed by alosetron, but it cannot be cured. If alosetron relieves your IBS symptoms and you stop taking it, your symptoms can come back within a week or two.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you want to use alostetron for anything other than what is prescribed.

What special precautions should I follow?

Before taking alosetron,

  • If you have an allergy to alosetron, any other medications, or any of the substances in alosetron tablets, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Tell your doctor if you’re using any of the drugs mentioned in the IMPORTANT WARNING section, including fluvoxamine (Luvox). If you’re taking any of these drugs, your doctor probably won’t let you take alosetron.
  • Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Make sure you bring up any of the following: a few antifungal medications, such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin), levofloxacin (Levaquin), norfloxacin (Noroxin), and others; hydralazine (apresoline); isoniazid (INH, Nydrazid); some HIV/AIDS medications such as atazanavir (Reyataz), darunavir (Prezista), fo (in Kaletra), tipranavir (Aptivus), procainamide (Procanbid, Pronestyl), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Fortovase, Invirase), and telithromycin (Ketek). Tell your doctor about all the drugs you are taking, even any not on this list, since many other drugs may also interact with alosetron. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have kidney illness, stomach or bowel issues, have previously undergone stomach or bowel surgery, or have any of the disorders listed in the IMPORTANT WARNING section.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while taking alosetron.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

When you remember taking a missed dose, do not. If a dose is missed, skip it and take the subsequent dose at the usual time. To make up for a missing dose, don’t take a second one.

What side effects can this medication cause?

Alosetron might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Uneasy stomach
  • Swelling around the stomach
  • Hemorrhoids

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of the signs and symptoms detailed in the IMPORTANT WARNING section.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088)

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from light, excessive heat, and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Lotronex®
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