Estradiol raises your risk of getting endometrial cancer (cancer of the lining of the uterus [womb]). The chance of developing endometrial cancer increases with the duration of estradiol use. You should be prescribed a progestin in addition to transdermal estradiol if you have not had a hysterectomy, a procedure to remove the uterus. Your risk of having endometrial cancer may be reduced, but your risk of acquiring certain other health issues, such as breast cancer, may increase. Inform your doctor if you have or have ever had cancer as well as if you experience irregular vaginal bleeding prior to starting to use transdermal estradiol. If you experience irregular or unusual vaginal bleeding while receiving transdermal estradiol, call your doctor right once. To assist ensure that you do not develop endometrial cancer during or after your treatment, your doctor will regularly monitor you.

Women who combined oral oestrogens (a class of drugs that includes estradiol) and progestins had an increased risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia, according to a big study (loss of ability to think, learn, and understand). These disorders may also be more likely to affect women who take transdermal estradiol either alone or in combination with progestins. Inform your doctor if you smoke or use tobacco, if you’ve ever had a heart attack or stroke, if anybody in your family has ever had breast cancer, or if you’ve ever had a blood clot. Additionally, let your physician know if you have ever experienced breast lumps, an abnormal mammogram, high blood pressure, high cholesterol or fat levels, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues, causing damage and swelling), high blood sugar, or high blood pressure (x-ray of the breast used to find breast cancer).

The major medical disorders mentioned above can present with any of the symptoms below. If you suffer any of the following signs while using transdermal estradiol, call your doctor right away: Speech difficulties, dizziness or faintness, sudden complete or partial vision loss, double vision, numbness or weakness in one arm or leg, crushing chest pain or chest heaviness, coughing up blood, sudden shortness of breath, trouble thinking clearly, remembering, or learning new things, breast lumps or other breast changes, discharge from nipples, or pain, tenderness, or redness in one leg are all symptoms of a sudden severe headache, vomiting, and headache of equal severity.

You can take precautions to lessen your chance of experiencing a significant health issue when using transdermal estradiol. Transdermal estradiol should not be used to prevent dementia, heart disease, heart attacks, or strokes on its own or in combination with a progestin. Use transdermal estradiol only as long as necessary and at the lowest dose necessary to control your symptoms. To determine if you should use a lower dose of transdermal estradiol or cease using the medicine, consult your doctor every three to six months.

To help find breast cancer as early as possible, you should check your breasts monthly and get a mammography and breast exam conducted by a doctor once a year. If you have a personal or family history of illness, your doctor will advise you on how to properly inspect your breasts and whether you need to have them checked more frequently than once a year.

If you are undergoing surgery or will be put on bed rest, let your doctor know. In order to reduce your risk of developing blood clots, your doctor may advise you to cease taking transdermal estradiol 4–6 weeks before to the procedure or place you on bedrest.

Regularly discuss the advantages and disadvantages of transdermal estradiol use with your doctor.

Compared to other brands of transdermal estradiol patches, Menostar® brand patches contain less oestrogen. Only women who are going through or have gone through menopause are prescribed Menostar® patches to prevent osteoporosis.

Transdermal estradiol is available as a skin patch. Depending on the brand of patch being used, transdermal estradiol is often applied once or twice a week. Some women wear a patch continuously, while others wear one on a rotating schedule that alternates 3 weeks of wearing the patch with 1 week of not wearing it. Every week, always apply your transdermal patch on the same day(s). You may be able to keep track of your patch change schedule on a calendar located on the inner flap of your drug box. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Transdermal estradiol should be applied exactly as prescribed. Apply the patches only as directed by your doctor, not more frequently or less often.

Transdermal estradiol will likely be prescribed to you at a modest dosage by your doctor, with the possibility of an increase if your symptoms continue to be troublesome. Your doctor will explain how to switch from the oestrogen medicine you are taking or using to transdermal estradiol if you are currently taking or using one. Make sure you comprehend these directions. Consult your doctor about the effectiveness of transdermal estradiol for you.

Apply the estradiol patches to the clean, dry, and cool skin on your lower abdomen, just below your waist. The upper buttocks can also receive some types of patches. The optimal location(s) to apply the brand of patches you received can be determined by consulting your doctor or pharmacist or by reading the manufacturer’s information included with your patches. Applying estradiol patches on skin that is greasy, damaged, cut, or irritated is not advised. Applying tight clothing or sitting down could rub the estradiol patches off at the waistline or the lower buttocks, respectively. Make sure there are no lotions, creams, or powders on the skin in the area where you intend to apply an estradiol patch. Wait at least a week after putting one patch to a specific location before applying another.

If you’re using an estradiol transdermal patch, ask your doctor or pharmacist if you need to be cautious when bathing, showering, or using a sauna. You can also read the manufacturer’s advice that came with your prescription. While some patch brands may loosen as a result of these activities, others are less likely to be harmed. When you change clothes or dry your body, your towel or clothes may tug and loosen some types of patches. After these actions, you might need to confirm that your patch is still securely fastened.

Try pressing the patch back into place with your fingertips if it becomes loose or comes off before it needs to be replaced. While doing this, take care to avoid touching the adhesive side of the patch with your fingertips. If the patch cannot be pressed back on, fold it in half so that it sticks to itself, dispose of it carefully where children and dogs cannot get it, and then apply a new patch to a separate spot. On your subsequent day of scheduled patch changes, replace the new patch.

Each brand of transdermal estradiol patch should be placed in accordance with the detailed instructions provided in the patient’s information provided by the manufacturer. Before using estradiol transdermal and each time you get a refill on your prescription, carefully read the following instructions. If you have any inquiries, speak with your physician or pharmacist. When using any kind of transdermal estradiol patch, the general instructions listed below can help you keep in mind a few key steps.

1. Pull the pouch apart with your fingertips. Avoid using scissors as they could harm the patch. Wait until you are prepared to apply the patch before opening the pouch.
2. From the pouch, remove the patch. To keep the patch dry within the pouch, there may be a silver foil sticker present. This sticker should remain in the pouch.
3. Press the patch’s sticky side against your skin in the location you’ve chosen to wear it by removing the patch’s protective lining. A liner on some patches is designed to come out in two sections. If your patch has that kind of liner, you should peel back a portion of it and press the patch’s exposed skin with that side. The second side of the patch should now be pressed against your skin after you have folded back the first side and peeled off the remaining liner. Avoid touching the adhesive side of the patch with your fingers at all times.
4. For 10 seconds, apply pressure to the patch with your fingers or palm. Make sure the patch is properly adhered to your skin, paying particular attention to the patch’s edges.
5. Wear the patch constantly until it’s time to take it off. When it’s time to take off the patch, peel it off your skin gradually. The patch should be disposed of safely, out of the reach of children and animals, by folding it in half and pressing the sticky sides together.
6. After removing the patch, if a sticky substance is still on your skin, you should wait 15 minutes before using an oil or lotion to get it off.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before using transdermal estradiol,

• Any brand of transdermal estradiol, any other estrogen-containing goods, any other drugs, any adhesives, or any of the components in estradiol transdermal patches should be disclosed to your doctor and pharmacist if you are allergic to any of these things. Request an ingredient list from your pharmacist.
• Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Incorporate any of the following: itraconazole (Sporanox, Tolsura), erythromycin (E.E.S., Eryc, Ery-Tab), carbamazepine (Carbatrol, Epitol, Tegretol, among others), ketoconazole, various estrogen-containing medicines, phenobarbital, ritonavir (Norvir, in Kaletra), rifampin (Rifadin, Rimactane), and thyroid medications such levothyroxine (Levoxyl, Synthroid, Tirosint). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all the drugs you are taking, even those not on this list, as many other drugs may also interact with estradiol transdermal patches.
• Be sure to mention St. John’s wort to your doctor if you use any herbal supplements.
• If you have a bleeding condition now or previously, let your doctor know; asthma, seizures, migraines, endometriosis, uterine fibroids (uterine growths that are not cancer), yellowing of the skin or eyes, particularly during pregnancy or if you were using an oestrogen product; extremely high or extremely low calcium levels in your blood; porphyria (condition where abnormal blood material build-up affects the skin or nervous system); either gallbladder, thyroid, pancreatic, liver, or renal problems; angioedema (a disorder that causes hives, breathing issues, and severe swelling of the face, lips, neck, tongue, hands, or feet).
• Inform your doctor if you are nursing a baby or want to become pregnant. Call your doctor if you become pregnant while using transdermal estradiol.
• Consult your doctor about additional methods of preventing osteoporosis if you are using transdermal estradiol, such as exercise, vitamin D supplementation, and/or calcium supplementation.

If you plan to consume grapefruits or grapefruit juice while taking this medication, consult your doctor.

Consult your doctor for advice on how to up your intake of calcium and vitamin D.

As soon as you remember, apply the forgotten patch. then proceed to apply the following patch in the usual manner. Applying multiple patches to make up for a missing patch is not advised.

Side effects from transdermal estradiol are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Breast discomfort or tenderness
• Nausea
• Vomiting
• Constipation
• Gas
• Heartburn
• Loss or increase of weight
• Hair fall
• Inflammation or redness of the skin under the estradiol patch
• Vaginal swelling, redness, stinging, itchiness, or irritation
• Virulent discharge
• Menstrual cramps that hurt
• Anxiety
• Depression
• Shifts in mood
• Altered sexual inclination
• Neck, back, or muscle ache
• Sniffles or congestion
• Skin on the face getting darker (may not go away even after you stop using transdermal estradiol)
• Undesirable hair growth
• Contact lens wearing challenges
• Joint discomfort

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

• The skin or eyes turning yellow
• Reduced appetite
• Fever
• Stomach pain, edoema, or sensitivity
• Itching
• Hives
• Rash, skin blisters, or other skin alterations
• Swelling of the hands, feet, ankles, throat, eyes, cheeks, lips, tongue, and lower legs
• Hoarseness
• Breathing or swallowing challenges

Your chance of getting gallbladder disease and ovarian cancer, both of which may require surgery to address, may increase if you use transdermal estradiol. Discuss the dangers of using transdermal estradiol with your doctor.

Children who utilise high dosages of transdermal estradiol for an extended period of time may experience slowed or early growth. When your kid receives transdermal estradiol medication, her doctor will keep a close eye on her progress. The hazards of giving your child this medication should be discussed with your child’s doctor.

Other negative effects of transdermal estradiol are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep estradiol patches away from children and tightly wrapped in their original pouches. Store the patches away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Overdose symptoms could include:

• Nausea
• Vomiting
• Uterine bleeding
• Breast sensitivity
• Continent pain
• Sluggishness or exhaustion

Keep all of your appointments with your physician and the lab. At least once every year, you should get a full physical assessment, which should include a pelvic exam. To monitor your body’s reaction to transdermal estradiol, your doctor could request specific lab tests.

Inform the lab staff and your doctor that you are using transdermal estradiol prior to any laboratory test.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.