WARNING

Alora (generic estradiol transdermal patch) is used primarily for hormone replacement therapy (HRT) in postmenopausal women. While it can be effective for managing menopausal symptoms like hot flashes and vaginal dryness, there are several risks and side effects associated with its use:

• Blood Clots: Estradiol can increase the risk of developing blood clots, which can lead to deep vein thrombosis (DVT), pulmonary embolism, or stroke.
• Stroke and Heart Attack: Hormone therapy, including estradiol, has been associated with a higher risk of stroke and heart attack, especially in women with pre-existing cardiovascular conditions.
• Increased Risk: Long-term use of estrogen therapy may increase the risk of breast cancer. Regular mammograms and breast exams are recommended.
• Risk Increase: If you have an intact uterus, using estrogen alone (without progesterone) can increase the risk of endometrial cancer. Combining estrogen with a progestin can reduce this risk.
• Cholecystitis and Gallstones: Estradiol therapy may increase the risk of gallbladder disease, including gallstones and inflammation of the gallbladder.
• Liver Function: Although rare, estradiol can cause liver problems or exacerbate existing liver conditions.
• Emotional Effects: Some women report mood swings, depression, or anxiety when using hormone therapy.
• Migraines: Estradiol may trigger or worsen migraines or severe headaches in some women.
• Application Site Reactions: The patch can cause local skin reactions, such as irritation, itching, or rash.
• Swelling: Hormone therapy can lead to fluid retention, causing swelling in the extremities.
• Drug Interactions: Estradiol can interact with other medications, potentially affecting their effectiveness or increasing side effects.

Before starting or continuing Alora, it’s important to discuss these risks with your healthcare provider, who can help weigh the benefits and risks based on your individual health profile. Regular monitoring and follow-up are crucial for managing any potential side effects or complications.

Why is this medication prescribed

Alora, which contains estradiol, is a transdermal patch used primarily for hormone replacement therapy (HRT) in postmenopausal women. It’s prescribed to help manage symptoms of menopause such as hot flashes, vaginal dryness, and mood changes. It can also be used to prevent osteoporosis in postmenopausal women who are at high risk for fractures. Additionally, it may be used for women who have had their ovaries removed or have other hormonal imbalances. The patch delivers estrogen directly into the bloodstream through the skin, providing a steady level of the hormone.

How should this medicine be used?

Alora (generic estradiol transdermal patch) should be used according to the following guidelines:

• Application: Apply the patch to a clean, dry area of skin on the lower abdomen or buttocks. Avoid areas where the skin is irritated, broken, or oily. Do not apply the patch to the breasts.
• Frequency: Change the patch twice a week, typically every 3 to 4 days. Follow the specific schedule prescribed by your healthcare provider.
• Rotation: Place each new patch on a different area of skin to reduce the risk of irritation. Avoid reusing the same spot for several weeks.
• Handling: When applying or removing the patch, handle it by the edges to avoid touching the sticky side. Press the patch firmly in place with the palm of your hand for about 10 seconds to ensure it adheres properly.
• Removal: Remove the old patch before applying a new one. Fold it in half with the sticky sides together and dispose of it according to local guidelines.
• Other Considerations: Avoid using lotions, oils, or powders on the area where the patch will be applied, as these can affect adhesion. If the patch falls off, apply a new one as soon as possible.

Always follow the specific instructions provided by your healthcare provider and the product’s label for the best results and to ensure safety.

Other uses for this medicine

Other Uses for Alora:

• Hormonal Therapy for Certain Conditions: Sometimes used to manage hormonal imbalances or conditions that require estrogen therapy beyond menopause, such as primary ovarian insufficiency or certain cases of hormone-responsive cancers under specific conditions.
• Post-Surgical Hormone Replacement: May be used for hormone replacement after surgical removal of ovaries or hysterectomy in some cases.

What special precautions should I follow?

Special Precautions for Alora:

• Medical History: Inform your healthcare provider if you have a history of blood clots, stroke, heart disease, liver disease, breast cancer, or endometrial cancer. Discuss any history of hormone-sensitive conditions or problems with the uterus.
• Monitoring: Regular check-ups may be necessary to monitor your response to the therapy and to check for potential side effects. You may need periodic mammograms and gynecological exams.
• Application Area: Avoid applying the patch to areas with skin conditions, rashes, or irritation. Do not apply the patch near the breasts or on areas where it might be rubbed off by clothing.
• Interactions: Inform your healthcare provider of all medications, including over-the-counter drugs, supplements, and herbal products, as some may interact with estrogen therapy. Certain medications can affect how well Alora works or increase the risk of side effects.
• Side Effects: Be aware of possible side effects such as nausea, headaches, mood changes, or skin irritation. Contact your healthcare provider if you experience severe side effects, such as unusual vaginal bleeding, severe headaches, chest pain, or symptoms of a blood clot (e.g., sudden swelling or pain in the legs).
• Pregnancy: Alora is not intended for use during pregnancy. Use effective contraception if you could become pregnant while using the patch.

Always follow your healthcare provider’s instructions and consult them if you have any concerns or experience unusual symptoms while using Alora.

What special dietary instructions should I follow?

• There are no specific dietary restrictions with Alora. However, maintaining a balanced diet can be beneficial for overall health and may help manage symptoms associated with hormone therapy.
• Ensure adequate intake of calcium and vitamin D, as these are important for bone health, particularly if you are using Alora for osteoporosis prevention.

What should I do if I forget a dose?

• Forgot to Change the Patch: If you forget to change the patch on the scheduled day, apply a new patch as soon as you remember. Continue with your regular schedule, changing the patch twice a week as prescribed.
• Missed Patch for an Extended Period: If the patch has been off for an extended period or if you have not changed it according to the prescribed schedule, contact your healthcare provider for guidance on how to proceed.
• Do Not Double Up: Do not apply more than one patch to make up for a missed dose.

What side effects can this medication cause?

Alora (generic estradiol transdermal patch) can cause a range of side effects. Some common and less severe side effects include:

• Skin Irritation: Redness, itching, or rash at the application site.
• Headache: Mild to moderate headaches.
• Nausea: Upset stomach or nausea.
• Breast Tenderness: Soreness or tenderness in the breasts.
• Mood Changes: Mood swings or emotional changes.

Less Common but More Serious Side Effects:

• Unusual Vaginal Bleeding: Unexpected bleeding or spotting.
• Severe Headaches: Intense headaches that may be accompanied by visual disturbances.
• Chest Pain: Pain or discomfort in the chest.
• Signs of Blood Clots: Swelling, pain, or redness in the legs; sudden shortness of breath; chest pain; or coughing up blood.
• Liver Problems: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain.
• Stroke: Symptoms may include sudden numbness or weakness, confusion, trouble speaking, or difficulty walking.
• Heart Attack: Symptoms can include chest pain, discomfort in the arms, back, neck, or jaw, shortness of breath, or nausea.
• Endometrial Hyperplasia or Cancer: Symptoms like abnormal vaginal bleeding or pelvic pain.

If you experience any severe or persistent side effects, contact your healthcare provider immediately. They can help determine if Alora is the right treatment for you and address any concerns.

What should I know about storage and disposal of this medication?

Storage and Disposal of Alora:

• Storage:
  • Keep the Alora patches in their original packaging until ready for use.
  • Store at room temperature, away from heat and moisture.
  • Keep the patches out of reach of children and pets.
• Disposal:
  • Dispose of used patches properly. Fold the patch in half with the sticky sides together and discard it in the household trash.
  • Do not flush patches down the toilet or throw them directly into the trash without folding.
  • Follow any specific disposal instructions provided by your pharmacy or healthcare provider.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms of an overdose may include nausea, vomiting, vaginal bleeding, or severe headaches.
• Action: If you suspect an overdose or experience severe symptoms, seek medical attention immediately. Contact emergency services or go to the nearest emergency room.

What other information should I know?

• Regular Monitoring: Keep up with regular appointments with your healthcare provider to monitor your response to the treatment and adjust as necessary.
• Drug Interactions: Inform your healthcare provider of all medications, supplements, and herbal products you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: Alora is not intended for use during pregnancy or breastfeeding. Use effective contraception if you could become pregnant.
• Emergency Contact: Have your healthcare provider’s contact information handy in case of any concerns or questions about your treatment.

Always follow your healthcare provider’s instructions and consult them if you have any questions or experience issues related to your use of Alora.