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Why is this medication prescribed?

Skin lesions connected to Kaposi’s sarcoma are treated with alitretinoin. It aids in halting the development of Kaposi’s sarcoma cells.

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

How should this medicine be used?

Gel-based alitretinoin is available. Alitretinoin is typically used twice daily. Depending on how you react to alitretinoin, your doctor may advise you to use it more or less frequently. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. As recommended, use alitretinoin. Use it only as directed by your doctor, neither more nor less often.

Although it does not treat Kaposi’s sarcoma lesions, alitretinoin can regulate them. Before a benefit is apparent, utilising alitretinoin must be used for at least two weeks. Results for some people might not be visible for 8 to 14 weeks. Without consulting your doctor, do not discontinue taking alitretinoin. To apply alitretinoin, do the following:

  1. Use gentle soap and water to properly wash your hands and the afflicted region of skin. Avoid using medicinal, abrasive, or drying soaps.
  2. Apply the drug with clean fingertips, a gauze pad, or a cotton swab.
  3. Apply enough gel to completely saturate the lesion.
  4. Only the affected skin area should get the medication. Avoid applying to unaffected areas and stay away from mucous membranes altogether.
  5. Prior to covering the gel with clothing, give it three to five minutes to dry.

What special precautions should I follow?

Before using alitretinoin,

  • If you have any drug allergies, including those to alitretinoin, etretinate, isotretinoin, tazarotene, or tretinoin, let your doctor and pharmacist know right away.
  • Tell your doctor about all of your current drugs, including vitamins and herbal remedies. Avoid using DEET-based insect repellents while taking alitretinoin.
  • If you have T-cell lymphoma, a kind of skin cancer, or have ever had it, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Dial your doctor right away if you find out you’re pregnant while taking alitretinoin. Pregnancy should not be anticipated while using alitretinoin.
  • Make a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin could become sun-sensitive if you take alitretinoin.

What should I do if I forget a dose?

As soon as you remember, use the missed dose. If the next dose is soon due, skip the missed one and carry on with your regular application regimen.

What side effects can this medication cause?

There may be negative effects from alitretinoin. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Skin warmth or a faint stinging sensation
  • Skin fading or becoming darker
  • Rosy, scaly skin
  • Rash
  • Skin that is swollen, blistered, or crusted
  • Symptoms of application site pain
  • Itching

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

What other information should I know?

Keep all appointments with your doctor. Alitretinoin is for external use only. Do not let alitretinoin get into your eyes, your nostrils, mouth, or any broken skin, and do not swallow it.

If your doctor has not instructed you to, avoid using dressings, bandages, cosmetics, lotions, or other skin treatments on the region being treated.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist. If your skin issue worsens or does not get better, let your doctor know.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Panretin®
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