Why is this medication prescribed?

Alitretinoin is primarily prescribed for treating Kaposi’s sarcoma, a type of cancer that often affects the skin and mucous membranes. It’s also sometimes used for other conditions where a topical retinoid might be beneficial.

How should this medicine be used?

Here’s how to use Alitretinoin:

• Clean and Dry: Make sure the affected area is clean and completely dry before applying the gel.
• Apply Thin Layer: Apply a thin layer of the gel to the affected area, usually once or twice daily as directed by your healthcare provider.
• Avoid Contact: Avoid applying the gel to open wounds or mucous membranes (e.g., inside the mouth, nose, or genitals). Also, be cautious about getting it in your eyes.
• Wash Hands: After application, wash your hands thoroughly to avoid transferring the gel to other areas or to other people.
• Avoid Sun Exposure: Alitretinoin can make your skin more sensitive to sunlight, so it’s important to protect the treated areas from sun exposure.
• Follow Directions: Always follow your healthcare provider’s instructions regarding the frequency and duration of use.

If you experience any irritation or adverse effects, consult your healthcare provider.

Other uses for this medicine

Alitretinoin is primarily used for treating Kaposi’s sarcoma, but it may also be prescribed off-label for conditions such as:

• Chronic eczema: It can be used to treat severe eczema that doesn’t respond to other treatments.
• Other skin conditions: Occasionally, it might be used for other dermatologic conditions where retinoid therapy could be beneficial.

What special precautions should I follow?

Special Precautions for Alitretinoin:

• Sun Sensitivity: Alitretinoin can increase your skin’s sensitivity to sunlight. Avoid direct sun exposure and use sunscreen with a high SPF to protect your skin.
• Pregnancy: Alitretinoin is not recommended for use during pregnancy due to the risk of birth defects. Ensure you are not pregnant and use effective contraception if you are of childbearing age.
• Eye Contact: Avoid getting the gel in your eyes, as it can cause irritation. If contact occurs, rinse your eyes thoroughly with water.
• Open Wounds: Do not apply the gel to broken or irritated skin.
• Interactions: Inform your healthcare provider of any other medications you are using, as there may be interactions.
• Application Areas: Avoid using the gel on large areas of the body unless specifically directed by your healthcare provider.
• Skin Reactions: If you experience severe irritation, redness, peeling, or other adverse effects, discontinue use and consult your healthcare provider.

Always follow your healthcare provider’s instructions and consult them if you have any concerns or experience unusual symptoms.

What special dietary instructions should I follow?

There are generally no specific dietary instructions for using Alitretinoin. However, maintaining a balanced diet and staying hydrated can support overall skin health and treatment efficacy. If you have any concerns about your diet while on Alitretinoin, it’s best to discuss them with your healthcare provider.

What should I do if I forget a dose?

• Missed Application: If you miss a dose, apply it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not apply extra gel to make up for a missed dose.
• Regular Schedule: Try to apply the gel at the same times each day to help remember.

What side effects can this medication cause?

Alitretinoin can cause a range of side effects, although not everyone will experience them. Common side effects include:

• Skin Reactions:
  • Redness
  • Dryness
  • Peeling or flaking
  • Itching or burning sensation
• Other Dermatological Effects:
  • Rash
  • Irritation
• Systemic Effects (less common but possible):
  • Headache
  • Fatigue
  • Nausea
• Sun Sensitivity: Increased sensitivity to sunlight, which can lead to sunburn or rash if sun exposure is not avoided.
• Eye Irritation: If the gel gets into the eyes, it can cause irritation, redness, or discomfort.

If you experience severe or persistent side effects, such as intense skin irritation or signs of an allergic reaction (e.g., swelling, severe rash, difficulty breathing), seek medical attention promptly. Always report any new or unusual symptoms to your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Alitretinoin:

Storage:

• Store Alitretinoin gel at room temperature, away from excessive heat or cold.
• Keep the container tightly closed when not in use to prevent contamination.
• Store in a dry place, away from direct sunlight and moisture.

Disposal:

• Do not flush Alitretinoin down the toilet or pour it into a drain.
• Follow local regulations for the disposal of medications. You may also use a medication take-back program or consult a pharmacist for guidance on safe disposal methods.

In case of emergency/overdose

• Emergency: If you experience a severe reaction, such as difficulty breathing, severe skin irritation, or an allergic reaction, seek emergency medical help immediately.
• Overdose: In the case of an overdose (e.g., applying significantly more gel than prescribed), contact your healthcare provider or a poison control center for advice. Overdosing on topical medications typically doesn’t result in severe systemic effects, but it’s important to follow up with a healthcare professional.

What other information should I know?

• Follow Instructions: Always follow your healthcare provider’s directions for application and use.
• Consult Regularly: Keep up with regular appointments to monitor your response to the medication and any potential side effects.
• Interactions: Inform your healthcare provider about all other medications and treatments you are using to avoid potential interactions.
• Pregnancy and Breastfeeding: If you are pregnant, plan to become pregnant, or are breastfeeding, consult your healthcare provider before using Alitretinoin.

If you have any more questions or concerns about using Alitretinoin, your healthcare provider can provide additional personalized information and support.