WARNING

Aliskiren is a medication used to treat high blood pressure, but it comes with some risks. Key concerns include:

• Kidney Issues: It can lead to kidney problems or worsening kidney function.
• Hyperkalemia: It might cause high potassium levels in the blood, which can be dangerous.
• Low Blood Pressure: It may cause excessive lowering of blood pressure.
• Pregnancy: It’s not recommended during pregnancy due to potential harm to the fetus.

Patients should be monitored regularly by their healthcare provider while on aliskiren to manage these risks.

Why is this medication prescribed?

Aliskiren is prescribed primarily to manage high blood pressure (hypertension). By inhibiting renin, an enzyme that plays a key role in the body’s blood pressure regulation system, aliskiren helps to lower blood pressure. This can reduce the risk of complications associated with hypertension, such as heart attack, stroke, and kidney damage.

How should this medicine be used?

Aliskiren should be used as follows:

• Dosage: Take aliskiren exactly as prescribed by your healthcare provider. The typical starting dose is often 150 mg once daily, which may be adjusted based on your response and tolerability.
• Administration: Aliskiren comes as a tablet to take by mouth. It can be taken with or without food. Try to take it at the same time each day to help remember.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose; do not double up to make up for a missed dose.
• Hydration: Ensure adequate hydration, as dehydration can increase the risk of side effects like low blood pressure.
• Regular Monitoring: Regular blood tests and check-ups are necessary to monitor blood pressure, kidney function, and potassium levels.

Always follow your healthcare provider’s specific instructions and consult them if you have any questions or concerns about your medication.

Other uses for this medicine

Other Uses for Aliskiren:

• Heart Failure: Although not a primary use, aliskiren may sometimes be considered in the management of heart failure.
• Chronic Kidney Disease: It can be used in certain cases to manage high blood pressure in patients with chronic kidney disease, but with caution.

What special precautions should I follow?

Special Precautions for Aliskiren:

• Kidney Function: Regular monitoring of kidney function is essential, as aliskiren can affect kidney performance.
• Potassium Levels: Watch for signs of high potassium levels (hyperkalemia) and have your potassium levels checked regularly.
• Pregnancy: Avoid using aliskiren during pregnancy, as it can harm the developing fetus.
• Drug Interactions: Inform your healthcare provider of all other medications you’re taking to avoid potential interactions.
• Dehydration: Maintain adequate hydration to prevent complications such as low blood pressure.
• Allergic Reactions: Report any unusual symptoms or signs of an allergic reaction, such as rash or swelling.

Always follow your healthcare provider’s guidance and report any side effects or concerns promptly.

What special dietary instructions should I follow?

• Potassium-Rich Foods: You may need to monitor your intake of potassium-rich foods (e.g., bananas, oranges, potatoes) as high potassium levels can be a concern with aliskiren.
• Salt Intake: Follow any specific advice from your healthcare provider regarding salt intake, especially if advised to manage your blood pressure.

What should I do if I forget a dose?

• Timing: If you remember within a few hours of the missed dose, take it as soon as you remember.
• Next Dose: If it’s almost time for your next dose, skip the missed dose and take your next dose at the regular time.
• Do Not Double Up: Avoid taking two doses at once to make up for a missed dose.

What side effects can this medication cause?

Aliskiren can cause several side effects. Common and serious side effects include:

Common Side Effects:

• Dizziness: Due to blood pressure changes.
• Fatigue: Feeling unusually tired or weak.
• Headache: Persistent headaches may occur.

Serious Side Effects:

• Kidney Issues: Symptoms might include changes in urine output, swelling in the legs, or sudden weight gain.
• Hyperkalemia: High potassium levels, which can cause symptoms like irregular heartbeats, muscle weakness, or numbness.
• Low Blood Pressure: Symptoms can include lightheadedness, fainting, or severe dizziness.
• Allergic Reactions: Rare but serious reactions may include rash, itching, swelling, severe dizziness, or trouble breathing.

If you experience any of these serious side effects or other unusual symptoms, contact your healthcare provider immediately. Regular monitoring and communication with your healthcare provider can help manage and mitigate these risks.

What should I know about storage and disposal of this medication?

Storage and Disposal of Aliskiren:

• Storage:
  • Store aliskiren at room temperature, away from excessive heat and moisture (usually between 59°F and 86°F or 15°C and 30°C).
  • Keep it in its original container, tightly closed, and out of reach of children and pets.
• Disposal:
  • Do not dispose of aliskiren in household trash or flush it down the toilet.
  • Use a drug take-back program or consult your pharmacist for proper disposal methods.
  • If no take-back programs are available, follow FDA guidelines for disposal.

In case of emergency/overdose

• Contact Emergency Services: If you suspect an overdose, seek immediate medical attention or call your local emergency services (911).
• Symptoms of Overdose: May include severe dizziness, fainting, or excessively low blood pressure.
• Emergency Information: Provide details about the medication and dosage taken to healthcare professionals.

What other information should I know?

• Regular Monitoring: Regular check-ups with your healthcare provider are essential to monitor blood pressure, kidney function, and potassium levels.
• Interactions: Inform your healthcare provider about all other medications, supplements, or herbs you are taking to avoid potential interactions.
• Lifestyle Modifications: Follow any recommended lifestyle changes, such as dietary adjustments or exercise, to support your treatment plan.
• Patient Information: Read the medication guide provided with your prescription for specific instructions and information related to aliskiren.

Always consult with your healthcare provider for personalized advice and guidance on managing your treatment with aliskiren.