The liquid solution form of pemetrexed injection is administered over a 10-minute period into a vein. A physician or nurse will inject you with pemetrexed in a clinic or infusion facility. Usually, it is administered once every 21 days.

To lessen some of the negative effects of this drug, your doctor may advise you to take other medications including folic acid (a vitamin), vitamin B12, and a corticosteroid like dexamethasone. You’ll receive instructions for taking these medications from your doctor. Carefully adhere to your doctor’s instructions. Any portion you do not understand, ask your physician or pharmacist to explain. Call your doctor if you forget to take one of these drugs.

You should undergo routine blood tests both before and during pemetrexed injectable therapy, according to your doctor. Based on the findings of the blood tests, your doctor may modify your pemetrexed injection dosage, postpone treatment, or permanently terminate your treatment.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before taking pemetrexed,

• If you have an allergy to pemetrexed, mannitol (Osmitrol), any other drugs, or any of the ingredients in pemetrexed injection, let your doctor and pharmacist know right once. For a list of the ingredients, consult your pharmacist or the manufacturer’s patient information.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Remember to bring up ibuprofen (Advil, Motrin). Ibuprofen shouldn’t be consumed the two days prior to, the day of, or for two days following a pemetrexed injection. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you have ever had kidney illness, have undergone radiation therapy, or both.
  Inform your doctor if you intend to father a child, are pregnant, or think you could get pregnant. If you are a female, you should take effective birth control during and for at least six months after getting pemetrexed injection. If you are a male, you should use reliable birth control while getting the pemetrexed injection and for three months following the last dosage. Call your doctor if you or your partner becomes pregnant while taking this medicine. The foetus could suffer from pemetrexed injection.
• Inform your doctor if you are nursing a child. Throughout your pemetrexed injectable treatment and for 1 week following the last dosage, you shouldn’t breastfeed.
• You should be aware that receiving a pemetrexed injection may lead guys to experience reproductive issues, which may impact your capacity to become a father. If these effects are reversible is unknown. The dangers of obtaining a pemetrexed injection should be discussed with your doctor.

Maintain your regular diet unless your doctor instructs you otherwise.

The injection of pemetrexed may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Reduced appetite
• Loss of weight
• Tiredness
• Having trouble falling or staying asleep
• Aching joints

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Blisters, skin sores, peeling skin, or uncomfortable ulcers in your mouth, lips, nose, throat, or genital region
• Radiation-treated areas that have swelling, blistering, or a rash that resembles a sunburn
• Uncommon bruising or bleeding
• Infection-related symptoms such a sore throat, fever, chills, and coughing
• Chest pain
• Rapid heart rate
• Breathing or swallowing challenges
• Slow or challenging speech
• Extreme fatigue or sluggishness
• Unsteadiness or weakness
• Arm or leg weakness or numbness
• Numbness, tingling, burning, or pain in the hands or feet
• Light skin
• Headache
• Hives
• Itching
• Less urinations

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the pemetrexed injection, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.