WARNING

Aleve PM (generic name naproxen) is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. Like all medications, it comes with potential risks and side effects. Here are some detailed risks associated with taking Aleve:

• Stomach Pain and Nausea: Common side effects include stomach pain, indigestion, and nausea.
• Ulcers and Bleeding: Long-term use or high doses can lead to stomach ulcers or gastrointestinal bleeding, which may be serious. Symptoms to watch for include black or tarry stools, vomiting blood, or severe stomach pain.
• Heart Attack and Stroke: Prolonged use of NSAIDs like naproxen can increase the risk of heart attack and stroke, especially at high doses or in individuals with existing heart conditions.
• High Blood Pressure: Naproxen can cause or worsen high blood pressure.
• Kidney Damage: Long-term use can affect kidney function, leading to potential kidney damage. Symptoms may include swelling in the legs, ankles, or feet, and changes in urine output.
• Liver Damage: Though rare, naproxen can cause liver problems. Symptoms include jaundice (yellowing of the skin or eyes), dark urine, and severe fatigue.
• Rashes and Swelling: Some people may experience allergic reactions, which can include rash, itching, or swelling. Severe reactions like anaphylaxis are rare but require immediate medical attention.
• Asthma Exacerbation: Naproxen may worsen asthma in some people.
• Blood Thinners: Naproxen can interact with blood thinners, increasing the risk of bleeding.
• Other NSAIDs: Using multiple NSAIDs simultaneously can increase the risk of adverse effects.
• Pregnancy: Naproxen is generally not recommended during the third trimester of pregnancy due to potential risks to the fetus and complications during delivery.
• Breastfeeding: Naproxen passes into breast milk, so consult a healthcare provider if breastfeeding.
• Pre-existing Conditions: Individuals with certain pre-existing conditions (e.g., peptic ulcer disease, severe heart disease, liver disease) should use naproxen with caution and under medical supervision.

Always use Aleve or any NSAID according to your healthcare provider’s directions and inform them of any other medications you are taking or health conditions you have. If you experience any severe or unusual symptoms while taking Aleve, seek medical attention immediately.

Why is this medication prescribed?

Aleve PM, which combines naproxen (a nonsteroidal anti-inflammatory drug, or NSAID) with diphenhydramine (an antihistamine), is often used to manage pain and help with sleep. The naproxen component addresses pain and inflammation, while diphenhydramine, known for its sedative effects, helps with insomnia. This combination can be prescribed for individuals who need relief from pain and also have difficulty sleeping due to that pain. However, it’s generally used for short-term management because of potential side effects and the risk of dependence on the sedative component.

How should this medicine be used?

Aleve PM should be used according to the following guidelines:

• Dosage: Follow the dosage instructions on the package or provided by your doctor. Typically, the recommended dose for adults is one caplet or tablet taken once daily at bedtime.
• Administration: Take Aleve PM with a full glass of water. It can be taken with or without food, but taking it with food might help reduce stomach irritation.
• Duration: Use Aleve PM for the shortest duration possible to manage symptoms. It is generally intended for short-term use for occasional sleeplessness due to pain.
• Avoid Overuse: Do not exceed the recommended dose or use Aleve PM for longer than directed. Overuse can lead to serious side effects.
• Interactions: Be cautious of interactions with other medications, particularly other pain relievers, sedatives, or alcohol.
• Medical Advice: Consult with a healthcare provider if you have any underlying health conditions or are taking other medications.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose; do not double up to make up for a missed dose.

If you have any specific questions or concerns about using Aleve PM, it’s best to discuss them with your healthcare provider.

Other uses for this medicine

Aleve PM (naproxen) is primarily used for:

• Occasional Insomnia: It can help with short-term sleep difficulties related to minor pain.
• Menstrual Pain Relief: If pain from menstruation disrupts your sleep, Aleve PM can provide relief and help you rest.

What special precautions should I follow?

Aleve PM combines naproxen (a nonsteroidal anti-inflammatory drug, or NSAID) with diphenhydramine (an antihistamine). Here are some precautions to keep in mind:

• Allergies: Avoid Aleve PM if you are allergic to naproxen, diphenhydramine, or other NSAIDs and antihistamines.
• Medical Conditions: Inform your doctor if you have conditions like asthma, liver or kidney disease, stomach ulcers, heart disease, high blood pressure, or any other chronic health issues.
• Interactions: Check for potential drug interactions, especially with other medications like blood thinners, other pain relievers, or sedatives.
• Dosage: Follow the dosage instructions carefully. Taking more than recommended can increase the risk of side effects.
• Drowsiness: Since Aleve PM contains diphenhydramine, it can cause drowsiness. Avoid driving, operating heavy machinery, or engaging in activities requiring alertness until you know how it affects you.
• Alcohol: Avoid alcohol, as it can increase drowsiness and the risk of stomach bleeding.
• Pregnancy and Nursing: Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Long-Term Use: Do not use Aleve PM for prolonged periods unless directed by a healthcare professional.

If you have any concerns or experience any unusual symptoms, contact your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary restrictions with Aleve PM, but it’s generally advisable to:

• Avoid Alcohol: Alcohol can increase the risk of side effects.
• Take with Food or Milk: If you have a sensitive stomach, taking Aleve PM with food or milk may help minimize gastrointestinal discomfort.

What should I do if I forget a dose?

• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Aleve PM can cause a range of side effects due to its combination of naproxen (an NSAID) and diphenhydramine (an antihistamine). Common side effects include:

Common Side Effects:

• Drowsiness: As diphenhydramine is a sedative, drowsiness is a common effect.
• Gastrointestinal Issues: Nausea, stomach pain, heartburn, or constipation may occur.
• Dizziness: This can result from both naproxen and diphenhydramine.

Less Common but Serious Side Effects:

• Allergic Reactions: Rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• Gastrointestinal Bleeding: Symptoms include black or bloody stools, vomit that looks like coffee grounds, or severe stomach pain.
• Kidney Issues: Symptoms like changes in urination or swelling in the legs/ankles.
• Liver Issues: Yellowing of the skin or eyes, dark urine, or severe fatigue.
• Heart Problems: Symptoms like chest pain, shortness of breath, or swelling in extremities.
• Impaired Coordination: Difficulty with balance or motor skills.
• Confusion or Difficulty Concentrating: Particularly in older adults.

If you experience any severe or concerning symptoms, seek medical attention immediately. Always use Aleve PM as directed and consult your healthcare provider if you have concerns about side effects or interactions with other medications.

What should I know about storage and disposal of this medication?

Storage and Disposal of Aleve (Naproxen):

Storage:

• Keep in a Cool, Dry Place: Store Aleve PM at room temperature, away from moisture and heat. Do not store in the bathroom.
• Keep Out of Reach of Children: Ensure that the medication is kept out of reach of children to prevent accidental ingestion.

Disposal:

• Do Not Flush: Avoid flushing Aleve PM down the toilet or pouring it down the drain unless instructed to do so.
• Drug Take-Back Programs: The best way to dispose of unused or expired medication is to use a drug take-back program or pharmacy disposal service.
• Household Trash: If no take-back programs are available, you can dispose of Aleve PM in the household trash by mixing it with an undesirable substance (like used coffee grounds or cat litter) and placing it in a sealed plastic bag or container.

In case of emergency/overdose

• Seek Immediate Medical Help: If you suspect an overdose or experience severe symptoms (e.g., nausea, vomiting, stomach pain, drowsiness, or difficulty breathing), contact emergency services or go to the nearest emergency room immediately.
• Contact Poison Control: You can also call the Poison Control Center for guidance. The number for the U.S. Poison Control Center is 1-800-222-1222.

What other information should I know?

• Follow Dosage Instructions: Adhere to the recommended dosage and frequency. Do not exceed the recommended dose or use it for longer than directed.
• Check Expiration Dates: Regularly check expiration dates and do not use expired medication.
• Consult Your Healthcare Provider: Always consult your healthcare provider if you have any questions or concerns about using Aleve PM, particularly if you have other health conditions or are taking other medications.

If you have any specific concerns or conditions, consulting with a healthcare professional is always a good idea.