Why is this medication prescribed?

Alecensa (generic name: alectinib) is prescribed primarily for the treatment of non-small cell lung cancer (NSCLC) that is positive for the anaplastic lymphoma kinase (ALK) gene mutation. It is often used when the cancer has progressed or cannot be treated effectively with other therapies.

How should this medicine be used?

Here’s how Alecensa is generally used:

• Dosage: Alecensa is usually taken orally in the form of capsules. The typical starting dose is 600 mg twice daily, but the exact dosage may vary based on the patient’s condition and how they respond to the medication.
• Administration: The capsules should be swallowed whole with water and can be taken with or without food. It’s important to take the medication at the same times each day to maintain consistent drug levels in your body.
• Monitoring: Regular check-ups with your healthcare provider are essential to monitor your response to the drug and manage any side effects. Your doctor may adjust the dose based on your individual needs and any side effects you experience.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about using Alecensa.

Other uses for this medicine

Alecensa (alectinib) is primarily used for treating non-small cell lung cancer (NSCLC) with an ALK gene mutation. Currently, its approved use is focused on this specific type of cancer. However, research may explore its potential for other conditions or in combination with other therapies.

What special precautions should I follow?

Special Precautions for Alecensa:

• Liver Function: Alecensa can affect liver function, so regular liver function tests are necessary. Inform your doctor if you experience symptoms of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain.
• Heart Health: Monitor for signs of heart problems, as alectinib can cause bradycardia (slow heart rate) or other cardiac issues. Report symptoms like dizziness, lightheadedness, or fainting to your healthcare provider.
• Lung Health: Watch for symptoms of lung issues, such as difficulty breathing, persistent cough, or chest pain. Alecensa can cause interstitial lung disease (ILD) or pneumonitis.
• Drug Interactions: Inform your healthcare provider about all other medications and supplements you’re taking, as Alecensa can interact with certain drugs. Some medications can affect how Alecensa is metabolized in the body.
• Pregnancy and Breastfeeding: Alecensa is not recommended during pregnancy due to potential harm to the fetus. Effective contraception is advised while on this medication. It’s also not recommended for breastfeeding.
• Allergic Reactions: Report any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing.

Always follow your healthcare provider’s guidance and consult them if you have concerns or experience any unusual symptoms while taking Alecensa.

What special dietary instructions should I follow?

• Food and Drink: Alecensa can be taken with or without food, but maintaining a consistent routine helps with absorption. Avoid grapefruit and grapefruit juice, as they can affect how Alecensa is metabolized.
• Hydration: Stay well-hydrated, as it helps with overall health and can assist in minimizing side effects.

What should I do if I forget a dose?

• If You Miss a Dose: Take the missed dose as soon as you remember, but if it’s almost time for your next dose, skip the missed dose. Do not double up on doses to make up for a missed one.
• Consult Your Healthcare Provider: If you’re unsure about what to do after missing a dose or if you have any concerns, contact your healthcare provider for guidance.

What side effects can this medication cause?

Alecensa (alectinib) can cause a range of side effects, which can vary in severity. Common side effects include:

• Fatigue: Feeling unusually tired or weak.
• Nausea and Vomiting: Feeling sick to your stomach or actually vomiting.
• Diarrhea: Frequent loose or watery bowel movements.
• Constipation: Difficulty passing stool or infrequent bowel movements.
• Muscle Pain: General aches or pain in the muscles.
• Headache: Persistent or severe headaches.
• Edema: Swelling, particularly in the hands, feet, or legs.
• Elevated Liver Enzymes: Indicating liver issues, which may not always have noticeable symptoms.

Serious side effects that require immediate medical attention include:

• Interstitial Lung Disease (ILD): Symptoms can include difficulty breathing, persistent cough, and chest pain.
• Severe Liver Problems: Symptoms may include jaundice (yellowing of the skin or eyes), severe abdominal pain, or dark urine.
• Bradycardia: Slow heart rate, which can cause dizziness, lightheadedness, or fainting.
• Severe Allergic Reactions: Symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing.

If you experience any severe or concerning symptoms, it’s important to contact your healthcare provider right away. They can help manage side effects and adjust treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Alecensa:

Storage:

• Store Alecensa at room temperature, away from heat and moisture. Typically, this means keeping it at 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original container to protect it from light and moisture. Ensure the container is tightly closed when not in use.
• Keep Alecensa out of reach of children and pets.

Disposal:

• Do not flush Alecensa down the toilet or pour it into a drain. Check if your pharmacy has a take-back program for unused medications.
• Many communities have drug take-back programs or disposal kiosks where you can safely dispose of unused or expired medications.
• If no take-back programs are available, you may follow specific disposal instructions provided with the medication or contact your pharmacist for guidance.

In case of emergency/overdose

• Symptoms of an overdose may not always be apparent but could include severe fatigue, nausea, vomiting, or symptoms related to severe side effects.
• If you suspect an overdose, contact your healthcare provider immediately or seek emergency medical attention. Provide as much information as possible about the dose taken and the time it occurred.
• Call emergency services (911 or your local emergency number) if you experience severe reactions or symptoms.
• Contact your local poison control center for guidance on managing an overdose.

What other information should I know?

• Regular Monitoring: Regular follow-up appointments and tests are crucial to monitor your response to Alecensa and manage any side effects.
• Interactions: Be aware of potential drug interactions. Always inform your healthcare provider about any other medications, vitamins, or supplements you are taking.
• Lifestyle Adjustments: Maintain a healthy lifestyle, including balanced nutrition and regular exercise, to support overall health during your treatment.
• Patient Information Leaflet: Read the patient information leaflet that comes with Alecensa for detailed information about the drug, including dosage, side effects, and other important details.

If you have any specific concerns or questions about Alecensa, your healthcare provider or pharmacist can provide personalized advice based on your health condition and treatment plan.