For the treatment of high blood pressure, methyldopa and hydrochlorothiazide are combined. In order to facilitate easier blood circulation throughout the body, methyldopa acts by relaxing the blood vessels. By removing surplus salt and water from the body, hydrochlorothiazide lowers blood pressure.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

To be taken orally, this drug is available as a tablet. Typically, it is consumed twice or three times day. Take methyldopa and hydrochlorothiazide at roughly the same times each day to help you remember to take them. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take hydrochlorothiazide and methyldopa precisely as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Although it doesn’t treat high blood pressure, this medicine manages it. Even if you feel good, keep taking hydrochlorothiazide and methyldopa. Without consulting your doctor, do not discontinue taking hydrochlorothiazide with methyldopa.

Other prescriptions for this drug are possible. For more information, consult your physician or pharmacist.

Before taking methyldopa and hydrochlorothiazide,

• If you have any allergies, including to methyldopa, hydrochlorothiazide, sulfa drugs, other medications, or any of the substances in methyldopa and hydrochlorothiazide tablets, tell your doctor and pharmacist right away. For a list of the ingredients, ask your doctor or pharmacist.
• Inform your physician if you are using an MAOs inhibitor, such as tranylcypromine (Eldepryl, Emsam, Zelapar), phenelzine (Nardil), isocarboxazid (Marplan), and selegiline (Eldepryl, Emsam) (Parnate). Most likely, your physician will advise against using hydrochlorthiazide and methyldopa.
• Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Any of the following should be mentioned: cholestyramine (Prevalite), digoxin (Lanoxin), haloperidol (Haldol), levodopa (in Sinemet, in Stalevo), lithium (Lithobid), diabetes drugs, prednisone (Rayos), probenecid (Probalan, in Col-Probenecid), and tolbutamide. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Avoid using methyldopa and hydrochlorthiazide at the same time if you are taking iron supplements or vitamins that contain iron. Find out from your doctor how long you should wait to take methyldopa after taking these supplements.
  Inform your doctor if you have diabetes, gout, high blood cholesterol, renal or liver disease, or have ever had any of these conditions.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking hydrochlorothiazide with methyldopa.
• If you are 65 years of age or older, discuss with your doctor the advantages and disadvantages of taking methyldopa plus hydrochlorothiazide. Methyldopa and hydrochlorothiazide are typically not recommended for older persons since they are less safe than alternative drugs that can be used to treat the same issue.
• Inform your physician or dentist that you are taking methyldopa and hydrochlorothiazide if you are undergoing surgery, including dental surgery.
• You should be aware that this medicine may cause you to feel sleepy. After starting this medication or after your dose has been adjusted, you should wait 48 to 72 hours before operating machinery or driving a car.
• Inquire with your doctor if drinking is safe for you to do while taking hydrochlorothiazide and methyldopa. The negative effects of methyldopa and hydrochlorothiazide can be exacerbated by alcohol.

Your doctor might advise a low-sodium or low-salt diet. Pay close attention to these guidelines.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Hydrochlorothiazide and methyldopa both have potential adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Dark faeces
• Often urinating
• Mouth ache
• Headache
• Uneasy stomach
• Vomiting
• Reduced appetite
• Diarrhea
• Gas
• Rash

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

• Extreme fatigue
• Weakened or cramping muscles
• Unidentified fever
• The skin or eyes turning yellow
• Difficulty breathing
• Swollen feet or ankles

Other negative effects of this medicine could occur. If you have any strange side effects while taking this medicine, contact your doctor right once.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Store away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. Regular blood pressure checks are necessary to monitor how well you are responding to methyldopa and hydrochlorothiazide.

Chew gum or suck hard candy to ease the dry mouth that methyldopa and hydrochlorothiazide induce.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.