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Aldactazide (Generic Spironolactone and Hydrochlorothiazide)

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Laboratory mice exposed to spirolactone developed tumours. Discuss the advantages and disadvantages of using this medication for your condition with your doctor.

When starting your treatment, you shouldn’t use this drug. Only once your doctor has determined the proper spironolactone and hydrochlorothiazide dosages for you specifically should you start taking this medicine.

Why is this medication prescribed?

Spironolactone and hydrochlorothiazide are used in conjunction to treat high blood pressure. Additionally, this drug is used to treat patients with edoema (fluid retention) brought on by a variety of illnesses, such as renal, liver, or cardiac problems. The drug spirolactone belongs to a group of drugs known as aldosterone receptor antagonists. It increases the amount of potassium lost from the body while causing the kidneys to excrete more water and sodium into the urine. Diuretics, also known as “water pills,” are a class of drugs that includes hydrochlorothiazide. It functions by causing the kidneys to excrete salt and water from the body through the urine.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

How should this medicine be used?

Spironolactone and hydrochlorothiazide are packaged as a tablet for oral consumption. Typically, it is consumed once or twice a day. Take spironolactone and hydrochlorothiazide at roughly the same time(s) each day to help you remember to take them. If you must take it once daily, do so in the morning; if you must take it twice daily, do so in the morning and in the late afternoon to prevent waking up in the middle of the night to use the restroom. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Spironolactone and hydrochlorothiazide should be taken exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

While controlling high blood pressure and edoema, this drug does not treat either of these disorders. Even if you feel better, keep taking hydrochlorothiazide and spironolactone. Without consulting your doctor, do not stop taking hydrochlorothiazide and spironolactone.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you’re interested in using this medication for any other conditions.

What special precautions should I follow?

Before taking spironolactone and hydrochlorothiazide,

  • If you have any allergies, including to penicillin, sulfa-based drugs, thiazide diuretics (often known as “water pills”), spironolactone, hydrochlorothiazide, or any of the substances in spironolactone and hydrochlorothiazide tablets, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: Aldosterone-blocking drugs like eplerenone (Inspra), benazepril, captopril, enalapril, lisinopril, moexipril, perindopril, quinapril, (Accupril, in Accuretic, in Quinaretic), ramipril, (Altace), and trandolapril are examples of angiotensin-converting enzyme (ACE) inhibitors. Benazepril is found in Lotrel, Capoten; ARBs (angiotensin receptor blockers) include angiotensin II antagonists such as losartan (Cozaar, in Hyzaar), irbesartan (Avapro, in Avalide), eprosartan (Teveten, in Teveten HCT), candesartan (Atacand, in Atacand HCT), and azilsartan (Edarbi, in Edarbyclor) (Benicar, in Azor, Benicar HCT), a spirin and other nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen (Advil, Motrin), indomethacin (Indocin, Tivorbex), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, in Exforge); cholestyramine (Prevalite); digoxin (Lanoxin), low molecular weight heparins like enoxaparin (Lovenox), lithium (Lithobid), diabetes or high blood pressure medications, potassium-sparing diuretics (also known as “water pills”) like amiloride (Midamor) or triamterene (Dyrenium, in Dyazide, in Maxzide), and potassium supplements. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have renal or liver illness, high blood potassium or calcium levels, Addison’s disease, other conditions that could raise potassium levels in the blood, or any of these conditions in the past. Your physician might advise against using hydrochlorothiazide plus spironolactone.
  • If you have diabetes, gout, asthma, or systemic lupus erythematosus (SLE, a chronic inflammatory disease), let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking hydrochlorothiazide and spironolactone.
  • Inform your doctor or dentist that you are taking spironolactone and hydrochlorothiazide if you are undergoing surgery, including dental surgery.
  • You should be aware that this medicine may cause you to feel sleepy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • Keep in mind that drinking alcohol can increase the drowsiness brought on by this drug.

What special dietary instructions should I follow?

A low-salt or low-sodium diet and a daily exercise regimen should be followed as prescribed by your doctor. Salt replacements with potassium should be avoided. Eat foods low in potassium in moderation (e.g., bananas, prunes, raisins, and orange juice). Find out from your doctor how much of these foods you should consume.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Hydrochlorothiazide with spirolactone may have negative side effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Reduced appetite
  • Abdominal pain
  • Often urinating
  • Dizziness
  • Headache
  • Big or uncomfortable breasts
  • Irregular intervals of menstruation
  • Having trouble getting or keeping an erection
  • Post-menopausal vaginal bleeding (after “the change of life,” the cessation of monthly menstrual cycles) women
  • Drowsiness

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Weakened or cramping muscles
  • Vision changes or eye pain
  • Rapid, uncontrollable weight loss
  • Fatigue
  • Irregular or slow heartbeat
  • Abnormal bleeding or bruising
  • The skin or eyes turning yellow
  • Skin rash
  • Itching
  • Fever
  • Confusion

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. Blood tests should be performed occasionally, and your blood pressure should be checked often.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

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