Treatment for wet age-related macular degeneration involves the injection of aflibercept (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). Additionally, it is used to treat diabetic macular edoema, which is an eye condition brought on by diabetes and can result in vision loss, diabetic retinopathy, and macular edoema following retinal vein occlusion, which is an eye condition brought on by a blockage of blood flow from the eye and causes blurred vision and vision loss (damage to the eyes caused by diabetes). Aflibercept injection belongs to the group of drugs known as VEGF-A and PlGF antagonists (sometimes known as VEGF-A and PlGF antagonists together). It functions by halting the development and leakage of aberrant blood vessels in the eye(s), which may result in vision loss in patients with specific eye disorders.

Aflibercept injection is a solution (liquid) that a physician injects directly into the eye. Usually, a doctor’s office administers it. According to a timetable that is ideal for you and your condition, your doctor will provide injections to you.

Your doctor will clean and numb your eye before to injecting you with aflibercept in order to prevent infection and minimise pain. Before you leave the office following your injection, your doctor will need to check your eyes.

The injection of aflibercept manages some eye diseases but does not treat them. Your doctor will closely monitor you to determine how effectively the aflibercept injection functions for you. How long you should continue receiving aflibercept injections for treatment should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving aflibercept injection,

• If you have an allergy to aflibercept, any other drugs, or any of the ingredients in aflibercept injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use.
• If you have an infection or swelling in or around your eye, let your doctor know. Most likely, your doctor will advise against getting an injection of aflibercept.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Before or throughout your aflibercept injection treatment, you shouldn’t get pregnant. Use reliable birth control before, during, and for three months after your therapy. Call your doctor if you get pregnant while having an injection of aflibercept.
• You should be aware that very away following your aflibercept injection, vision issues could arise. Drive a car or use machinery only once your vision has returned to normal.

Keep eating normally unless your doctor instructs you otherwise.

Call your doctor as soon as you can if you are unable to make an appointment to receive an injection of aflibercept.

Aflibercept injectable side effects are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Noticing anything in your eye
• Bleak eyes

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Eye discomfort or redness
• Light sensitivity in the eyes
• Reduction or modification of vision
• Eye bleeding or eyelid bleeding
• Observing “floaters” or tiny dots
• Hurting after injection
• Observing light flashes
• Chest discomfort
• Breathing difficulty
• Sweating
• Slow or challenging speech
• Unsteadiness or weakness
• Arm or leg weakness or numbness
• Rash
• Itching
• Hives
• Breathing or swallowing challenges

Aflibercept injection could result in additional adverse effects. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your doctor’s appointments.

Ask your pharmacist any inquiries you may have regarding the injection of aflibercept.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.