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Advair Diskus (Generic Fluticasone and Salmeterol Oral Inhalation)

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Why is this medication prescribed?

Fluticasone and salmeterol (Advair Diskus, Advair HFA, AirDuo Respiclick) are used to treat the symptoms of asthma, including breathing difficulties, wheezing, shortness of breath, coughing, and chest tightness. Additionally, C. o. pulmonary disease-related chest tightness, coughing, wheezing, and shortness of breath are prevented and treated with the fluticasone and salmeterol combination (Advair Diskus) (COPD; a group of lung diseases that includes chronic bronchitis and emphysema). Fluticasone and salmeterol are combined to form the Advair Diskus medication, which is prescribed to both adults and children over the age of four. Children 12 and older can utilise the fluticasone and salmeterol combination (Advair HFA, AirDuo Respiclick). Fluticasone belongs to the group of drugs known as steroids. It lessens airway edoema, which is how it works. Salmeterol belongs to a group of drugs known as long-acting beta-agonists (LABAs). Breathing becomes simpler as a result of the lungs’ opening and relaxation.

How should this medicine be used?

Fluticasone and salmeterol are available as a powder and an oral solution for inhalation through a specially crafted inhaler. It is typically utilised twice daily, in the morning and evening, separated by roughly 12 hours. Use salmeterol and fluticasone at around the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Salmeterol and fluticasone must be used exactly as prescribed. Use it only as directed by your doctor, neither more nor less often.

During your therapy with salmeterol and fluticasone inhalation, discuss with your doctor how you should take any additional oral or inhaled asthma drugs. Your doctor would generally advise you to discontinue regularly taking a short-acting beta agonist inhaler, such as albuterol (Proventil, Ventolin), but to keep using it to treat unexpected bouts of asthma symptoms. Pay close attention to these guidelines. Without first consulting your doctor, never alter how you take any of your drugs or stop taking any of them.

During an asthma or COPD attack, avoid using fluticasone and salmeterol. To use during attacks, your doctor will prescribe a short-acting inhaler.

Inhaling fluticasone and salmeterol reduces the symptoms of some lung disorders but does not treat them. Before you experience the full benefits of fluticasone and salmeterol, it could take a week or longer. Even if you feel good, keep taking salmeterol and fluticasone. Fluticasone and salmeterol should not be stopped without consulting your doctor. Your symptoms can reappear if you stop using fluticasone and salmeterol inhalation.

Read the enclosed written package instructions before using fluticasone and salmeterol inhalation (Advair Diskus, Advair HFA, or AirDuo Respiclick) for the first time. Make sure you are familiar with all the elements of the inhaler by carefully studying the illustrations and instructions on the packaging. You should request instructions on using the inhaler from your physician, pharmacist, or respiratory therapist. While they are watching, practise using your inhaler to be sure you are doing it correctly.

Make sure your child is familiar with how to use fluticasone and salmeterol inhalation if they will be using it. Make sure your child uses the inhaler correctly by watching them each time.

Never disassemble the inhaler, wash the mouthpiece, or use the inhaler to exhale into. Dry off the inhaler. The inhaler must not be used with a spacer.

Request a copy of the patient’s manufacturer’s information for the fluticasone and salmeterol inhalation (Advair Diskus, Advair HFA, or AirDuo Respiclick) from your pharmacist or physician.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using fluticasone and salmeterol oral inhalation,

  • If you have any allergies, including those to milk protein, any foods, fluticasone (Flonase, Flovent), salmeterol (Serevent), any other medications, or any of the substances in fluticasone and salmeterol oral inhalation, let your doctor and pharmacist know right once. For a list of the ingredients, consult the patient information or speak with your pharmacist.
  • Inform your physician if you take any additional LABAs, such as salmeterol or formoterol (Perforomist, Dulera, and Symbicort) (Serevent, in Advair). Fluticasone and salmeterol inhalation should not be used together with these drugs. Your doctor will advise you on which medications to take and which to quit using.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you’re using. Incorporate any of the following: beta-blockers including atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), and propranolol (Inderal); clarithromycin (Biaxin, in Prevpac); diuretics (‘water pills’); specific antifungals like itraconazole (Onmel, Sporanox) and ketoconazole; atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase) are HIV protease inhibitors. Other asthma or COPD treatments. Seizure meds. Metronidazole (Flagyl). Nefazodone (Ketek; no longer available in U.S.). Additionally, let your doctor and pharmacist know if you’ve recently stopped using any of the following medications: Amitriptyline, amoxapine, doxepin, silenor, imipramine, nortriptyline (Pamelor), clomipramine (Anafranil), desipramine (Norpramin), protriptyline, and others are antidepressants (Vivactil), and trimipramine (Surmontil); as well as monoamine oxidase (MAO) inhibitors such as tranylcypromine (Eldepryl, Emsam, Zelapar), isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), and phenelzine (Parnate). Fluticasone and salmeterol may also interact with many other drugs, so be sure to let your doctor know about all the drugs you’re taking, even if they don’t appear on this list. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had osteoporosis (a condition in which the bones become brittle and weak), high blood pressure, irregular heartbeat, seizures, hyperthyroidism (overactive thyroid), diabetes, tuberculosis (TB), cataracts (clouding of the lens of the eye), glaucoma (an eye disease), any condition that affects your immune system, liver or heart disease, or hyperthyroidism (overactive thyroid). Additionally, let your doctor know if you smoke or use tobacco products, have a herpes eye infection, or any other sort of infection.
  • Inform your doctor if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you get pregnant while taking salmeterol and fluticasone.
  • Inform your doctor or dentist that you are using fluticasone and salmeterol if you are undergoing surgery, including dental surgery.
  • If you have never had chickenpox or measles and have not had a vaccination against these diseases, let your doctor know. Avoid sick people, especially those who have the measles or chickenpox. Call your doctor right once if you are exposed to these infections or if you start to experience their symptoms. To safeguard yourself against certain infections, you might need to receive a vaccine (shot).

What special dietary instructions should I follow?

If you plan to consume grapefruit or grapefruit juice while taking this medicine, consult your doctor.

What should I do if I forget a dose?

Ignore the missed dose and carry on with my normal dosing routine. To make up for a missing dose, do not take a second dose.

What side effects can this medication cause?

Salmeterol and fluticasone may have negative side effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Clogged nose
  • Sneezing
  • Unwell throat
  • Throat annoyance
  • Sinus pain
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Bone and muscle discomfort
  • Dizziness
  • Weakness
  • Tiredness
  • Sweating
  • Tooth ache
  • Shaking of a body part that you are unable to control
  • Issues with sleep

Some adverse effects can be very harmful. Call your doctor right away if you suffer any of the following side effects:

  • Chest tightness, wheezing, or cough that starts immediately after using fluticasone and salmeterol inhalation
  • Hives
  • Rash
  • Swelling of the lower legs, hands, feet, ankles, or face, throat, tongue, and lips
  • Choking or swallowing issues
  • Hoarseness
  • High-pitched, clamorous respiration
  • Erratic or pounding heartbeat
  • Fainting
  • Chest discomfort
  • Cough
  • Tingling or burning in the feet or hands
  • Mouth with white spots
  • Fever, chills, and other infection-related symptoms


Salmeterol and fluticasone may make kids grow more slowly. The physician for your child will keep a close eye on his or her development. The hazards of giving your child this medication should be discussed with your child’s doctor.

Fluticasone and salmeterol may make you more likely to get cataracts or glaucoma. During your fluticasone and salmeterol treatment, you’ll probably need to undergo regular eye exams. If you have any of the following symptoms, including eye pain, redness, or irritation; blurred vision; seeing haloes or vivid colours around lights; or any other changes in vision, let your doctor know straight once. Discuss the dangers of using this drug with your doctor.

Your chance of developing osteoporosis may increase if you take fluticasone and salmeterol. Discuss the dangers of using this drug with your doctor.

Salmeterol and fluticasone may also have other adverse effects. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from sunshine, excessive heat, and moisture at room temperature (not in the bathroom). Consult your pharmacist for advice on how to properly dispose of your medications.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Seizures
  • Chest discomfort
  • Dizziness
  • Fainting
  • Distorted vision
  • Hammering, rapid, or erratic heartbeat
  • Nervousness
  • Headache
  • Shaking of a body part that you are unable to control
  • Muscle weakness or cramps
  • Mouth ache
  • Nausea
  • Excessive fatigue
  • Not enough energy
  • Having trouble falling or staying asleep

What other information should I know?

Remain on time for all of your doctor’s and eye doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Advair® Diskus
  • Advair® HFA
  • AirDuo® Respiclick
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