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ADP Sodium (Generic Pamidronate Injection)

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Why is this medication prescribed?

Pamidronate is used to treat elevated blood calcium levels that may result from specific forms of cancer. Pamidronate is also used in conjunction with chemotherapy to treat bone damage brought on by multiple myeloma (a type of cancer that starts in the plasma cells, a type of white blood cell that generates chemicals essential to fight infection), as well as by breast cancer that has spread to the bones. Additionally, Paget’s disease is treated with pamidronate (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Pamidronate injection belongs to the bisphosphonates class of drugs. It works by delaying bone deterioration, boosting bone density (thickness), and reducing the quantity of calcium released from the bones into the blood.

How should this medicine be used?

Pamidronate injection is available as a solution (liquid) that is injected gradually over 2 to 24 hours into a vein. Usually, it is injected by a medical professional in a clinic, hospital, or doctor’s office. It can be administered as a single dose that can be repeated after 1 week or more, as a daily dose for 3 days straight, or once every 3 to 4 weeks. The course of treatment is determined by your condition.

During your therapy, your doctor might advise you to take a calcium supplement and a multivitamin that contains vitamin D. These supplements should be taken daily as prescribed by your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving pamidronate injection,

  • If you have an allergy to pamidronate injection, alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), tiludronate (Skelid), zoledronic acid (Zometa), any other drugs, or any of the ingredients in pamidronate injection, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Incorporate any of the following: chemotherapeutic drugs for cancer, thalidomide, and oral steroids such dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone) (Thalomid). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of your current medications, even those not on this list, as many additional drugs may interact with pamidronate injection.
  • Inform your doctor if you are undergoing radiation therapy, have undergone thyroid surgery, have ever experienced seizures, or suffer from liver or kidney illness.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While using pamidronate, you should utilise an effective method of birth control to avoid getting pregnant. Dial your doctor right away if you get pregnant while taking pamidronate. If you intend to conceive in the near future, discuss your plans with your doctor because pamidronate may stay in your system for years after you stop using it.
  • You should be aware that pamidronate can seriously harm your jaw, particularly if you have dental care or undergo surgery while taking the medicine. Before you begin taking pamidronate, a dentist should check your teeth and carry out any necessary procedures. While receiving pamidronate, make sure to thoroughly brush your teeth and care for your mouth. Before getting any dental work done while taking this medication, see your doctor.
  • You should be aware that pamidronate injection may produce excruciating pain in the joints, muscles, or bones. Within days, months, or even years of receiving your initial pamidronate injection, you can start to experience severe pain. It’s critical that you and your doctor understand that this type of discomfort could be brought on by pamidronate, even though it might not appear until after you’ve been receiving pamidronate injections for some time. If you ever feel significant pain while receiving pamidronate injection therapy, call your doctor straight once. When you stop taking pamidronate injection, your discomfort may go away and your doctor may stop administering it to you.

What special dietary instructions should I follow?

Continue eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you forget to take your pamidronate dose or your appointment to take it, call your doctor right away.

What side effects can this medication cause?

Side effects from a pamidronate injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, erythema, or edoema at the injection site
  • Abdominal pain
  • Reduced appetite
  • Constipation
  • Nausea
  • Vomiting
  • Heartburn
  • Alterations in food taste
  • Infections in the mouth
  • Fever
  • Headache
  • Dizziness
  • Excessive fatigue
  • Having trouble falling or staying asleep
  • Coughing
  • Having a difficult or painful urinating
  • Hand, arm, foot, ankle, or lower leg swelling

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Bruised or painful gums
  • Tooth sensitivity
  • Jaw tingling or feeling heavy
  • Jaw healing is not very good
  • Vomit that is reddish-colored or resembles coffee grounds
  • Stools that are red or dark and tarry
  • Breathing difficulty
  • Rapid heart rate
  • Fainting
  • Muscles tensing up quickly
  • Tingling or numbness in the mouth
  • Tears or eye ache

Other negative consequences from pamidronate injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Your healthcare practitioner will provide instructions on how to store this medication if you are administering it at home. Pay close attention to these directions.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Fever
  • Alterations in food taste
  • Muscles tensing up quickly
  • Tingling or numbness in the mouth

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the pamidronate injection, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aredia®
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