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Admelog (Generic Insulin Lispro Injection)

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Why is this medication prescribed?

Type 1 diabetes is treated with medications containing the insulin lispro injection (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). People with type 2 diabetes (a condition in which the body does not utilise insulin normally and cannot control the quantity of sugar in the blood) who require insulin to control their diabetes can also be treated with insulin lispro injectable solutions. Unless it is used in an external insulin pump, insulin lispro injectable products are always administered to patients with type 1 diabetes together with another type of insulin. Insulin lispro injectable products can be combined with another kind of insulin or with oral diabetic medications in people with type 2 diabetes. Products for injecting insulin lispro are synthetic, short-acting substitutes for human insulin. Insulin lispro injectable products function by substituting for the insulin that the body normally produces and by assisting in the movement of blood sugar into other body tissues where it is utilised as an energy source. They likewise prevent the liver from generating additional sugar.

People with diabetes and high blood sugar over time may experience serious or fatal complications, such as heart disease, stroke, kidney issues, nerve damage, and vision issues. It may be possible to control your diabetes and enhance your health by using medication(s), making lifestyle changes (such as diet, exercise, and quitting smoking), and routinely checking your blood sugar. This treatment may also lower your risk of heart attack, stroke, kidney failure, nerve damage (resulting in numb, cold legs or feet and diminished sex capacity in both men and women), eye issues, such as changes in eyesight or blindness, or gum disease, which are all symptoms of diabetes. The optimal strategy to manage your diabetes will be discussed with you by your doctor and other healthcare professionals.

How should this medicine be used?

Products for injecting subcutaneously with insulin lispro are available as a solution (liquid) and a suspension (liquid with particles that will settle on standing) (under the skin). Typically, insulin lispro solution (Admelog, Humalog) is administered within 15 minutes after or right after eating. 15 minutes prior to a meal, inject insulin lispro suspension (Humalog Mix 75/25 or Humalog Mix 50/50). The insulin lispro-aabc solution (Lyumjev) should be administered 20 minutes or less before you begin eating a meal. How frequently you should administer insulin lispro products each day will be determined by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow all instructions when using insulin lispro injectable products. Use it only as directed by your doctor, neither more nor less often.

In a medical environment, a doctor or nurse may also inject insulin lispro injectable products intravenously (into a vein). You will be closely observed by a doctor or nurse for side effects.

When experiencing hypoglycemia (low blood sugar) symptoms or after checking your blood sugar and finding it to be low, never use insulin lispro injectable products.

Diabetes cannot be cured but is controlled by insulin lispro injectable products. Even if you feel well, keep taking medications containing insulin lispro. Without consulting your doctor, never discontinue using insulin or lispro injectable products. Without consulting your doctor, never switch to a different brand or type of insulin or alter the dosage of any type of insulin you are now on. To ensure that you obtained the correct type of insulin from the pharmacy, always check the label on the insulin bottle.

Vials, dosing pens with medication-filled cartridges, and cartridges with dosing pens are the three different forms that insulin lispro injectable products are available in. Make sure you are aware of the sort of container your insulin lispro comes in as well as any additional equipment you will require to inject your prescription, such as needles, syringes, or pens.

You will need syringes to administer your dose if the insulin lispro injection medication you are using is supplied in vials. Ask your physician or pharmacist to demonstrate how to use a syringe to administer an insulin lispro injectable product. If you have any concerns about the kind of syringe you ought to use, consult your physician or pharmacist.

If your insulin lispro injectable product is a cartridge-based device, you will also need to buy an insulin pen. To determine what kind of pen is best for the cartridge size you are using, consult the manufacturer’s information for the patient. Read the pen’s instructions thoroughly, and then ask your doctor or pharmacist to demonstrate how to use it. If you have any concerns concerning the kind of pen you ought to use, consult your physician or pharmacist.

Make careful to read and comprehend the manufacturer’s instructions if your insulin lispro injectable product is in a pen. You can get the pen’s instructions from your doctor or pharmacist. Always prime the pen before use, and carefully follow the instructions.

Never share needles, syringes, cartridges, or pens, and never reuse needles or syringes. Always take out the needle from an insulin pen as soon as you’ve finished injecting your dose. Put needles and syringes in a container that won’t puncture. For disposal instructions on the puncture-resistant container, consult your doctor or pharmacist.

Your doctor might advise you to use the same syringe to administer your insulin lispro solution together with another type of insulin (NPH insulin). You will be given detailed instructions by your doctor. Always inject the insulin right away after mixing, always use the same brand of syringe, and always draw insulin lispro into the syringe first. Other than NPH insulin, insulin preparations other than insulin lispro injectable products shouldn’t be combined. No other insulin preparations should be used with insulin lispro suspension.

To make it simpler to monitor your dose, your doctor may advise you to dilute insulin lispro injection products prior to administration. You will be given detailed instructions by your doctor.

Your thighs, stomach, upper arms, or buttocks are all acceptable locations to administer your insulin lispro injection medication. With each dose, switch (rotate) the injection location inside the designated area. Avoid injecting into sections of skin that are thick, lumpy, painful, bruised, scaly, or hard, or into skin that has scars or has been harmed.

Before injecting your insulin, always check the label. The insulin used in lispro solution should be transparent and colourless. If the insulin lispro product is coloured, hazy, or includes solid particles, do not use it. If you’re using insulin lispro suspension, the insulin after mixing should seem murky or milky. If the liquid contains clumps or if there are solid white particles adhering to the bottle’s bottom or walls, do not use this kind of insulin product. Any form of insulin should not be used after the expiration date indicated on the bottle.

Before using, the insulin lispro suspension needs to be gently mixed by being shook or rubbed between your palms. If you need to combine the type of insulin you are taking, ask your doctor or pharmacist how to do it.

Admelog, Humalog U-100, and Lyumjev U-100 are examples of insulin lispro solutions that can be used with an external insulin pump. Read the pump label to confirm that it is possible to use the pump for continuous fast-acting insulin delivery before utilising insulin lispro products in a pump system. Ask your doctor or pharmacist to demonstrate how to use the insulin pump, and read the pump manual for information on suggested reservoir and tube settings. When using insulin lispro with an external insulin pump, do not dilute it or combine it with any other type of insulin. When utilising insulin lispro products with an external insulin pump, change the infusion set and infusion set insertion site at least every 3 days, and replace the insulin in the reservoir at least every 7 days (Admelog, Humalog U-100), or at least every 9 days (Lyumjev U-100). Use an alternative infusion site and notify your doctor if the infusion site becomes red, itchy, lumpy, or thickened.

High blood sugar may occur quickly while using insulin lispro solution in an external insulin pump if the pump malfunctions or if the insulin in the pump reservoir is exposed to direct sunlight or temperatures higher than 98.6°F (37°C). If the tube leaks, kinks, blocks, disconnects, or becomes detached, high blood sugar may also result. Call your doctor right away if the issue cannot be identified and fixed straight away. It’s possible that you’ll need to utilise insulin subcutaneously for a while (using syringes or an insulin pen). Ensure you have extra insulin on hand, as well as any other tools or supplies, and ask your doctor or pharmacist to demonstrate how to use them.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using an insulin lispro injection product,

  • If you have any allergies, including to any of the substances in insulin lispro injection products (Humulin, Novolin, and others), insulin lispro, insulin lispro-aabc, or any other medicines, tell your doctor right away. For a list of the ingredients, consult your pharmacist or the manufacturer’s patient information.
  • Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are taking. Incorporate any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Epaned, Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Qbrelis, Zestril, in Zestoretic), moexipril, perindopril (in Prestalia), quina;  Azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), and olmesartan are angiotensin receptor blockers (Benicar, in Azor, in Benicar HCT, in Tribenzor), beta blockers include atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), and nadolol. Telmisartan is found in the drugs Micardis, Micardis HCT, Twynsta, and Diovan. Valsartan is found in the drugs Diovan, Diovan HCT, Entresto, and Exforge (Corgard), and propranolol (Inderal); a few drugs used to decrease cholesterol, including niacin (Niacor, Niaspan, in Advicor), gemfibrozil (Lopid), and fenofibrate (Antara, Lipofen, TriCor, Triglide, among others); a few anti-HIV drugs, such as atazanavir (Reyataz, in Evotaz), darunavir (Prezista, in Prezcobix, in Symtuza), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), saquina; diuretics (‘water pills’); fluoxetine (Prozac, in Symbyax); hormone replacement therapy; isoniazid (in rifater, rifamate); lithium (Lithobid); drugs for asthma and colds; clonidine (Catapres); clozapine (Clozaril, Versacloz); danazol; disopyramide (Norpace); drugs for nausea and mental illness; octreotide (Mycapssa, Sandostatin); monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate); oral contraceptives (birth control pills), oral diabetes medications like pioglitazone (Actos, in Actoplus Met and others), and rosiglitazone (Avandia), oral steroids like dexamethasone (Hemady), methylprednisolone (Medrol), and prednisone (Rayos), patiromer (Veltassa), pentamidine (NebuPent, Pentam), aspirin, choline magnesium trisalicylate (Trisalate), choline salicylate (Arthropan), diflunisal, magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic) are examples of salicylate pain relievers. Other examples include sodium polystyrene sulfonate (Kalexate, Kionex, SPS), somatropin (Nutrop Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had heart failure, low blood potassium levels, diabetes-related nerve damage, or any other health issues, such as liver, renal, or heart problems. Additionally, let your doctor know if you have hypoglycemia on a regular basis.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you get pregnant while using insulin lispro injectable products.
  • Inform the surgeon or dentist that you are using an insulin lispro injectable product if you are having surgery, including dental surgery.
  • Alcohol may alter blood sugar levels. While taking an insulin lispro injection product, find out from your doctor whether it’s safe to consume alcoholic beverages and take prescription or over-the-counter drugs that include alcohol.
  • When you become ill, suffer extraordinary stress, modify your diet, exercise routine, or activity schedule, consult your doctor for advice. Your dosing regimen and the amount of insulin you may need may alter as a result of these modifications.
  • You should be aware that if you use insulin lispro injection products for the first time or have a significant dose increase, you could develop blurred vision or other vision issues as well as a painful, burning, weak, or numb sensation in your hands, arms, feet, or legs. These side effects ought to fade away, but if they persist, let your doctor know.
  • Find out from your doctor how frequently you should test your blood sugar. Be mindful that hypoglycemia can impair your ability to do activities like driving, and ask your doctor if you should check your blood sugar before operating machinery or driving.

What special dietary instructions should I follow?

Make sure to abide by any dietary advice given to you by your physician or nutritionist. It’s crucial to maintain a healthy diet and eat the same foods in the same amounts at around the same times every day. Your ability to control your blood sugar levels may suffer if you skip or delay meals, change the quantity or type of food you eat, or all three.

What should I do if I forget a dose?

It is necessary to inject insulin lispro injectable products right before or right after a meal. Inject the missed dose as soon as possible if you remember to take it just before or directly after eating. If it has been some time since your last meal, call your doctor to inquire about whether you should inject the missed dose or follow your doctor’s advice. To make up for a missing dose, do not provide a second injection.

What side effects can this medication cause?

Your blood sugar levels may alter as a result of this drug. You should be aware of the signs of low and high blood sugar as well as what to do if you experience these signs.

Products for injecting insulin lispro may have negative effects. If any of the following symptoms are severe or persistent, consult your doctor:

  • Redness, swelliness, or itching where you administered the insulin lispro
  • A change in the texture of your skin, such as thickening, a little depression, or skin bumps
  • gaining weight
  • Constipation

Some adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right once if you notice any of them:

  • Rash and itching, breathing issues, hives, wheezing, a rapid heartbeat, sweating, and feeling sleepy, disoriented, or dizzy
  • Face, tongue, or throat swelling
  • Weakness, cramping muscles, irregular pulse
  • Breathing difficulty
  • Quite a bit of weight gain quickly
  • Arms, hands, foot, ankles, or lower legs swelling

Other negative effects of insulin lispro could occur. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication out of the reach of children and in the original container. Vials, cartridges, and pens for insulin lispro that have not been opened should be refrigerated rather than frozen. Refrigerated insulin lispro products should be kept refrigerated until the date specified on the manufacturer’s label. The unopened vials, cartridges, or pens of insulin lispro solution (Admelog, Humalog, Lyumjev) should be kept at room temperature and away from strong sunlight and extreme heat if a refrigerator is not available (for instance, while on vacation). Insulin lispro solution vials, cartridges, and pens (Admelog, Humalog, Lyumjev) that have not been opened or refrigerated must be thrown away after 28 days. Insulin lispro suspension vials (Humalog 50/50, Humalog 70/25) that have not been opened or refrigerated can be used within 28 days and unopened, unrefrigerated pens can be used within 10 days before being thrown.

Admelog and Humalog insulin lispro solution vials can be kept open for up to 28 days at room temperature or in the fridge. A vial of diluted Humalog can be kept for 28 days in the fridge or 14 days at room temperature, a vial of diluted Admelog can be kept for 1 day (24 hours) in the fridge or 4 hours at room temperature, and a vial of diluted Lyumjev can be kept for 4 days in the fridge or 12 hours at room temperature, if your doctor instructs you to dilute your insulin lispro injection product solution. Do not store opened insulin lispro solution (Admelog, Humalog) cartridges or pens in the refrigerator; instead, keep them at room temperature for up to 28 days. Opened Humalog 50/50 or Humalog 75/25 pens can be kept at room temperature for up to 10 days; refrigeration is not required. Lyumjev (insulin lispro solution) pens that have already been opened can be kept at room temperature for up to 28 days. Any insulin lispro product that has been in a temperature extreme should be thrown away.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

If you use the recommended dosage of insulin lispro injection products, but you eat less than normal or exercise more than usual, you could have an overdose of the medication. An excess of insulin lispro might result in hypoglycemia. Follow your doctor’s recommendations for what to do if you experience any hypoglycemia-related symptoms. Other overdose signs include:

  • Coma
  • Seizures

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how well your body is responding to insulin lispro injectable products, your doctor will request specific lab tests. Your doctor will also instruct you on how to measure your blood sugar levels at home to determine how well you are responding to insulin and lispro injectable products. Pay close attention to these directions.

Wearing a diabetes identity bracelet will ensure that you receive the right care in an emergency.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Admelog®
  • Humalog®
  • Humalog® Mix50/50
  • Humalog® Mix75/25
  • Lyumjev®(insulin lispro-aabc)
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