WARNING

Activella is a medication used for hormone replacement therapy (HRT) in postmenopausal women. It combines estrogen and progestin to help manage symptoms of menopause and prevent osteoporosis. However, it comes with several risks:

• Blood Clots: Increases the risk of developing blood clots, which can lead to deep vein thrombosis or pulmonary embolism.
• Stroke and Heart Attack: May elevate the risk of stroke and heart attack, particularly in women with existing cardiovascular risk factors.
• Breast Cancer: Prolonged use is associated with an increased risk of breast cancer.
• Endometrial Cancer: In women with a uterus, there’s a risk of endometrial cancer if not paired with a progestin.
• Gallbladder Issues: Can lead to gallbladder disease or exacerbate existing conditions.
• Liver Issues: Potential liver complications, though rare.

It’s essential to discuss these risks with your healthcare provider to determine if Activella is appropriate for you and to monitor for any side effects.

Why is this medication prescribed?

Activella is a prescription medication used primarily for hormone replacement therapy (HRT) in postmenopausal women. It combines two hormones, estradiol (an estrogen) and norethindrone (a progestin), to help manage symptoms of menopause, such as hot flashes, vaginal dryness, and to prevent bone loss. It can also be used to regulate menstrual cycles in women who haven’t gone through menopause yet but need hormonal treatment for other reasons.

How should this medicine be used?

Activella is usually taken as a daily oral tablet. The typical dosage is one tablet per day, taken at the same time each day to help remember to take it consistently. Here are some general guidelines for using Activella:

• Follow the Prescription: Take the medication exactly as prescribed by your healthcare provider. Do not take more or less than directed.
• Daily Routine: Take your tablet at the same time each day to help keep your hormone levels steady.
• Consistency: Try to take your medication consistently each day to ensure its effectiveness.
• Missed Dose: If you miss a dose, follow the instructions provided by your healthcare provider or check the medication guide. Generally, you should take the missed dose as soon as you remember, but if it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
• Check with Your Provider: Regular follow-ups with your healthcare provider are important to monitor your progress and adjust the dosage if needed.

Always read and follow the specific instructions provided with your medication, and consult your healthcare provider with any questions or concerns.

Other uses for this medicine

In addition to managing menopausal symptoms and preventing bone loss, Activella can sometimes be prescribed for other hormone-related issues, such as irregular menstrual cycles or to provide hormone support in women who have had a hysterectomy but still need estrogen therapy. However, its primary use is for menopause management.

What special precautions should I follow?

Special Precautions for Activella:

• Medical History: Inform your healthcare provider if you have a history of certain medical conditions, including:
  • Blood clots or clotting disorders
  • Heart disease or stroke
  • Liver disease
  • Breast cancer or other hormone-sensitive cancers
  • Uncontrolled high blood pressure
  • Diabetes
• Regular Check-Ups: Regular check-ups with your healthcare provider are important to monitor for any side effects or complications.
• Monitoring for Side Effects: Be aware of potential side effects such as:
  • Breast tenderness
  • Nausea
  • Headaches
  • Mood changes
  • Unusual vaginal bleeding
• Drug Interactions: Inform your healthcare provider about all other medications and supplements you are taking, as some can interact with Activella.
• Pregnancy: Activella is not intended for use during pregnancy. If you become pregnant while taking Activella, contact your healthcare provider immediately.
• Smoking: If you smoke, discuss this with your healthcare provider, as smoking can increase the risk of certain side effects associated with hormone therapy.

Always follow the advice of your healthcare provider and report any unusual symptoms or concerns promptly.

What special dietary instructions should I follow?

• General Diet: There are no specific dietary restrictions for Activella, but maintaining a balanced diet can support overall health.
• Alcohol: Moderate alcohol consumption is generally acceptable, but excessive alcohol can affect liver function and may interact with hormone therapy.
• Calcium and Vitamin D: Ensure adequate intake of calcium and vitamin D to support bone health, especially since Activella is used for osteoporosis prevention.

What should I do if I forget a dose?

• Timing: If you remember within 12 hours of the missed dose, take it as soon as you can. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
• Instructions: Follow any specific instructions provided by your healthcare provider or refer to the medication guide for guidance.
• Consult Your Provider: If you miss multiple doses or have any concerns, contact your healthcare provider for advice.

What side effects can this medication cause?

Activella, like all medications, can cause side effects. While not everyone experiences them, here are some potential side effects associated with Activella:

Common Side Effects:

• Breast Tenderness: Sensitivity or pain in the breasts.
• Nausea: Feeling queasy or having an upset stomach.
• Headaches: Pain or discomfort in the head.
• Mood Changes: Emotional swings or changes in mood.
• Spotting or Bleeding: Light bleeding or spotting between periods.

Less Common but Serious Side Effects:

• Blood Clots: Symptoms may include swelling, pain, or redness in the legs, or sudden shortness of breath.
• Stroke or Heart Attack: Symptoms can include sudden numbness or weakness, especially on one side of the body, difficulty speaking, sudden vision changes, or chest pain.
• Liver Issues: Symptoms might include jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.
• Unusual Vaginal Bleeding: Especially if it occurs after the first few months of use.
• Breast Lump: Any new or unusual lumps in the breast should be evaluated.

Allergic Reactions:

• Rash, Itching, or Swelling: Especially in the face, tongue, or throat.
• Severe Dizziness or Fainting: Which could indicate a severe allergic reaction.
• Report Side Effects: Inform your healthcare provider about any side effects you experience, especially if they are severe or persistent.
• Seek Medical Attention: If you experience symptoms of a serious side effect, such as severe chest pain, sudden difficulty breathing, or signs of a stroke, seek immediate medical attention.

Always follow your healthcare provider’s advice and report any unusual symptoms or concerns promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal of Activella:

• Storage:
  • Temperature: Store Activella at room temperature, away from excess heat and moisture. Typically, this means keeping it in a dry place away from direct sunlight.
  • Container: Keep the medication in its original container, tightly closed to protect it from moisture.
• Disposal:
  • Do Not Flush: Do not flush Activella down the toilet or pour it into a drain unless instructed to do so.
  • Drug Take-Back Programs: Check if there are any local drug take-back programs or disposal sites in your area. These are often the safest way to dispose of unused or expired medications.
  • Household Disposal: If no take-back programs are available, you can dispose of the medication in household trash, but make sure to mix it with an undesirable substance (like used coffee grounds or cat litter) and place it in a sealed bag or container to prevent accidental ingestion.

In case of emergency/overdose

• Symptoms of Overdose:
  • Nausea and Vomiting: Feeling sick to the stomach or throwing up.
  • Unusual Bleeding: Heavy or prolonged bleeding.
  • Dizziness or Fainting: Feeling lightheaded or faint.
  • Contact Emergency Services: If you suspect an overdose or experience severe symptoms, seek immediate medical attention by calling emergency services or going to the nearest emergency room.
  • Poison Control: You can also contact a poison control center for guidance on what to do.

What other information should I know?

• Follow-Up Appointments: Regular check-ups with your healthcare provider are important to monitor your response to the medication and adjust the dosage if necessary.
• Consistency: Taking Activella at the same time every day helps maintain hormone levels and improves effectiveness.
• Medication Review: Keep your healthcare provider informed about any other medications, supplements, or herbal products you are taking to avoid potential interactions.
• Lifestyle Factors: A healthy lifestyle, including a balanced diet and regular exercise, can support overall health and enhance the effectiveness of your treatment.
• Patient Information: Always read the patient information leaflet provided with your medication for specific instructions and information.

If you have any additional questions or concerns about Activella, your healthcare provider or pharmacist can provide more personalized advice.