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Why is this medication prescribed?

Prednisone and a particular kind of prostate cancer that has spread to the body’s other organs are combined to treat the condition. A group of drugs known as androgen biosynthesis inhibitors includes abiraterone. It functions by lowering the body’s levels of specific hormones.

How should this medicine be used?

A pill form of abiraterone is available to be taken orally with water on an empty stomach, one hour before or two hours after consuming any food. Typically, it is taken once or twice a day. Take abiraterone every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take abiraterone as prescribed by your doctor. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not split, chew, or crush the pills; instead, swallow them whole with water.

Abiraterone should still be used even if you are feeling OK. Prednisone or abiraterone should not be stopped abruptly without consulting your doctor.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking abiraterone,

  • If you have an allergy to abiraterone, any other drugs, or any of the ingredients in abiraterone tablets, inform your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Dextromethorphan, carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek), among other seizure treatments, should be mentioned. Ketoconazole, nefazodone, pioglitazone (Actos), rifabutin (Mycobutin), rifampin (Rifadin, in R Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all the drugs you are taking, including any not on this list, since many other drugs may also interact with abiraterone.
  • Infections, low potassium levels, unusual stress, adrenal or pituitary gland issues, heart failure, an irregular heartbeat, including QT prolongation (an irregular heart rhythm that can cause fainting, loss of consciousness, seizures, or sudden death), high blood pressure, heart or liver disease, or any other medical condition should be disclosed to your doctor.
  • Abiraterone should only be used in men, as you are aware. In particular, women who are breastfeeding or who may become pregnant shouldn’t take this drug. Abiraterone may be harmful to the foetus if taken by pregnant women. Without safety gloves, women who are, could become, or might become pregnant should avoid handling abiraterone tablets. A pregnant woman should call her doctor right once if she consumes or comes into contact with abiraterone tablets.
  • Men taking abiraterone who have a female partner must utilise reliable contraception during the course of treatment and for three weeks following the last dose. Consult your doctor about the birth control methods that are best for you.
  • You should be aware that this drug may reduce male fertility. The dangers of using abiraterone should be discussed with your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Take your regular dose the following day if you miss one. Call your doctor as soon as possible if you miss more than one dose.

What side effects can this medication cause?

Side effects from abiraterone are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Joint edoema or discomfort
  • Groyne ache
  • Hot flash (a sudden wave of mild or intense body heat)
  • Diarrhoea
  • Heartburn
  • Cough
  • Difficulty Sleeping or remaining asleep

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Dizziness
  • Feeling lightheaded or dizzy
  • Headache
  • Confusion
  • Rapid or erratic heartbeats
  • Muscular pains or weakness
  • Leg ache
  • Edoema of the lower legs, ankles, feet, or hands
  • Rash
  • Significant bruising or bleeding
  • Not enough energy
  • Extreme fatigue
  • Nausea
  • Vomiting
  • Appetite loss
  • Yellowing of the skin or eyes
  • Pain in the upper right portion of the stomach
  • Flu-like signs, including fever
  • Urinary blood
  • Frequent, painful, or challenging urinating
  • Bone breakage

Other negative effects of abiraterone are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. Regular blood pressure checks are advised. To determine how well your body is responding to abiraterone, your doctor will request a few lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Zytiga®
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