There is a chance that using abacavir, lamivudine, or zidovudine will result in a severe or fatal allergic reaction. If you experience any of the following symptoms, call your doctor right away to discuss whether you should stop taking abacavir, lamivudine, and zidovudine:

• Group 1: fever
• Group 2: rash
• Group 3: abdominal pain, vomiting, diarrhoea, or nausea
• Group 4: overall malaise, excessive exhaustion, or ache
• Group 5: wheezing, coughing, or sore throat

Each time you obtain a prescription from your pharmacist, you will receive a warning card. To help you and those around you identify an allergic reaction, the Warning Card includes a list of the symptoms indicated above. Keep this Warning Card with you at all times.

Based on their genetic makeup or ancestry, certain people may be more susceptible to experience an adverse reaction when using abacavir. Prior to starting abacavir, lamivudine, and zidovudine, your doctor may request a genetic blood test to ascertain whether you are more prone to experience an allergic reaction to abacavir. If you are allergic to abacavir or any other abacavir-containing drugs, or if you are aware that you have a certain genetic composition, let your doctor and pharmacist know right once. Never take abacavir, lamivudine, or zidovudine (or a drug containing abacavir) again if your doctor instructs you to stop taking them because you experienced an adverse reaction. Abacavir, lamivudine, and zidovudine should not be restarted without first consulting your doctor if you stop taking them for any other reason, such as missing many doses in a row or running out of medication. Even if you’ve never had a reaction to abacavir, lamivudine, or zidovudine before, restarting them raises your risk of getting one. When you restart this drug, you’ll need to be near individuals who can get emergency medical help or call for it if it’s necessary.

Zidovudine, lamivudine, and abacavir may prevent your body from producing enough red blood cells. Inform your physician if you now have or have ever had anaemia, bone marrow issues, a low quantity of any type of blood cells, or any other blood diseases. Call your doctor right away if you have any of the following symptoms: Shortness of breath, pale complexion, fever, chills, and other infection-related symptoms, as well as excessive exhaustion or weakness, are all markers of atypical health.

Muscle problems could be brought on by zidovudine, lamivudine, and abacavir. If you have or have ever had a muscular illness or muscle swelling, let your doctor know. Call your doctor right away if you feel any weakening or pain in your muscles.

Lactic acidosis, a potentially fatal illness, and potentially life-threatening liver damage are risks associated with abacavir, lamivudine, and zidovudine (buildup of lactic acid in the blood). If you have liver illness now or ever had it, let your doctor know. Your doctor will generally advise against using abacavir, lamivudine, and zidovudine if you have liver illness. If you are female, extremely obese, or have used nucleoside reverse transcriptase inhibitor drugs like abacavir, lamivudine, and zidovudine for a long period, you may also be at an elevated risk of getting lactic acidosis. Get emergency medical care if you encounter any of the following symptoms, or call your doctor right away: nausea, vomiting, pain in your upper right stomach, loss of appetite, flu-like symptoms, extreme exhaustion, unusual bleeding or bruising, weakness, dizziness, lightheadedness, fast or irregular heartbeat, difficulty breathing, dark yellow or brown urine, light-colored bowel movements, yellowing of the skin or eyes, feeling cold, especially in your arms or legs, or muscle pain that is different from any muscle pain you typically experience.

Hepatitis B virus infection should not be treated with abacavir, lamivudine, or zidovudine (HBV; an ongoing liver infection). If you suspect you may have HBV, let your doctor know. Before you start your treatment with abacavir, lamivudine, and zidovudine, your physician may do a test to determine whether you have HBV. When you quit taking abacavir, lamivudine, or zidovudine if you have HBV, your condition could abruptly get worse. For several months after you stop using this medicine, your doctor will check on you and place lab testing to see if your HBV has gotten worse.

When you start taking abacavir, lamivudine, or zidovudine as part of a treatment plan as well as each time you get a prescription refill, your doctor or pharmacist will provide you the medication guide (patient information sheet) provided by the manufacturer. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the Food and Drug Administration (FDA) website.

The dangers of using abacavir, lamivudine, and zidovudine should be discussed with your doctor.

To treat human immunodeficiency virus (HIV) infection, abacavir, lamivudine, and zidovudine may be used alone or in combination with other drugs. Nucleoside reverse transcriptase inhibitors are a class of drugs that includes abacavir, lamivudine, and zidovudine (NRTIs). They function by lowering the level of HIV in the blood. Although the trifecta of abacavir, lamivudine, and zidovudine does not treat HIV, it may lessen your risk of contracting AIDS and other HIV-related diseases such serious infections or cancer. The danger of transferring the HIV virus to other people may be reduced by taking these medications, engaging in safer sexual behaviour, and altering other aspects of one’s lifestyle.

Abacavir, lamivudine, and zidovudine are available as a tablet for oral use. It is often taken twice daily, with or without food. Take zidovudine, lamivudine, and abacavir at around the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the directions on the label for abacavir, lamivudine, and zidovudine. Never take it in larger or less amounts or more frequently than directed by your doctor.

Zidovudine, lamivudine, and abacavir assist manage HIV infection but do not treat it. Even if you feel OK, keep taking abacavir, lamivudine, and zidovudine. Without consulting your doctor, don’t stop taking abacavir, lamivudine, and zidovudine. If you skip doses or stop using abacavir, lamivudine, or zidovudine, your condition can get worse or you might experience an allergic response when you resume taking the drug (See Important Warning section).

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before taking abacavir, lamivudine, and zidovudine,

• If you have any allergies to any of the components of abacavir, lamivudine, or zidovudine tablets, tell your doctor and pharmacist. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Medication for cancer, methadone (Dolophine, Methadose), nelfinavir (Viracept), probenecid (Probalan, in Col-Probenecid), ribavirin (Copegus, Rebetol, Ribasphere), stavudine (Copegus, Rebetol, Ribasphere), valproic acid, and emtricitabine are among the drugs that are used. Emtricitabine (Depakene). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Abacavir, lamivudine, and zidovudine may all interact with one another, so be sure to let your doctor know about any of the drugs you’re taking, even those that aren’t on this list.
• Inform your doctor if you smoke, consume alcohol, have high blood pressure, high cholesterol, diabetes, heart disease, kidney disease, or if you’ve previously had any of the conditions listed in the IMPORTANT WARNING section.
• Inform your doctor if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you conceive while taking abacavir, lamivudine, or zidovudine. If you have HIV or are taking abacavir, lamivudine, or zidovudine, you shouldn’t breastfeed.
• You need to be aware that your body fat may expand or shift to several regions, including your upper back, neck (the “buffalo hump”), breasts, and the area surrounding your abdomen. Your face, legs, and arms may show a reduction of body fat.
• You should be aware that while you use medications to treat your HIV infection, your immune system could become stronger and start to fight other infections you previously have in your body or trigger the development of other illnesses. You might start to exhibit signs of certain illnesses as a result of this. Throughout your course of abacavir, lamivudine, and zidovudine therapy, be careful to let your doctor know if you experience any new or worsening symptoms.

Keep eating normally unless your doctor instructs you otherwise.

Zidovudine, lamivudine, and abacavir could all have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Anxiety
• Depression
• Headache

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you encounter any of the signs and symptoms mentioned in the IMPORTANT WARNING section.

Zidovudine, lamivudine, and abacavir may also have unwanted consequences. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Headache
• Vomiting
• Extreme fatigue

Keep all of your appointments with your physician and the lab. To determine how your body is responding to abacavir, lamivudine, and zidovudine, your doctor may request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

Abacavir, lamivudine, and zidovudine should always be available. Do not put off getting a refill on your prescription until you are out of medicine.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.