Why is this medication prescribed?

Dostarlimab-gxly is a prescription medication used to treat certain types of cancer. Specifically, it belongs to a class of drugs called immune checkpoint inhibitors, which work by helping the immune system recognize and attack cancer cells. Dostarlimab-gxly is typically prescribed for the treatment of advanced or recurrent endometrial cancer (cancer of the lining of the uterus) that has not responded to other treatments.

How should this medicine be used?

Dostarlimab-gxly is typically administered as an intravenous (IV) infusion by a healthcare professional in a clinical setting, such as a hospital or infusion center. The exact dosage and schedule for Dostarlimab-gxly will be determined by your healthcare provider based on factors such as the type and stage of cancer being treated, your overall health, and any other medications you may be taking.

Before each infusion, your healthcare provider will perform necessary checks to ensure that you are suitable for treatment with Dostarlimab-gxly. During the infusion, you will be closely monitored for any signs of an allergic reaction or other adverse effects.

It’s important to follow your healthcare provider’s instructions regarding the dosage and schedule for Dostarlimab-gxly precisely. Do not change the dosage or frequency of administration without consulting your healthcare provider. If you have any questions or concerns about the use of Dostarlimab-gxly, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Dostarlimab-gxly injection is primarily indicated for the treatment of certain types of cancer, particularly advanced or recurrent endometrial cancer. However, it may also be used off-label or in clinical trials for other types of cancer or medical conditions. Off-label use refers to the use of a medication for a purpose other than what it was approved for by regulatory agencies.

What special precautions should I follow?

Regarding special precautions for Dostarlimab-gxly injection, it’s important to consider the following:

• Allergic Reactions: Inform your healthcare provider about any known allergies, especially to other medications, and report any signs of allergic reactions during or after receiving Dostarlimab-gxly injection, such as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Immune-related Adverse Events (irAEs): Dostarlimab-gxly is an immune checkpoint inhibitor, which can cause the immune system to attack normal cells in addition to cancer cells. This may lead to immune-related adverse events, such as inflammation of the lungs (pneumonitis), intestines (colitis), liver (hepatitis), hormone glands (endocrinopathies), or skin (dermatitis). These side effects can be serious and require prompt medical attention.
• Infections: Since Dostarlimab-gxly can suppress the immune system, there is an increased risk of developing infections. Report any signs or symptoms of infection to your healthcare provider immediately, such as fever, chills, cough, sore throat, difficulty breathing, or unusual tiredness.
• Pregnancy and Breastfeeding: Dostarlimab-gxly may harm an unborn baby, so it is important to avoid becoming pregnant while receiving treatment and for some time afterward. Similarly, it is not recommended to breastfeed while receiving Dostarlimab-gxly injection and for some time after the last dose.
• Other Medications and Supplements: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as some may interact with Dostarlimab-gxly and affect its effectiveness or increase the risk of side effects.
• Regular Monitoring: Your healthcare provider will monitor you closely for any signs of side effects or complications during treatment with Dostarlimab-gxly. Be sure to attend all scheduled appointments and report any concerns promptly.

Always follow your healthcare provider’s instructions and guidelines for the safe and effective use of Dostarlimab-gxly injection, and do not hesitate to ask any questions or seek clarification about your treatment plan.

What special dietary instructions should I follow?

Regarding special dietary instructions for Dostarlimab-gxly injection, there are no specific dietary restrictions associated with this medication. However, maintaining a healthy and balanced diet can support overall well-being and may aid in managing potential side effects of cancer treatment. It’s essential to stay hydrated and consume a variety of nutrient-rich foods unless advised otherwise by your healthcare provider.

What should I do if I forget a dose?

If you forget a dose of Dostarlimab-gxly injection, contact your healthcare provider or clinic as soon as possible to reschedule the missed dose. Do not attempt to administer the medication yourself or double up on doses to make up for the missed one without consulting your healthcare provider first. They will provide guidance on the appropriate course of action based on your individual treatment plan and schedule.

What side effects can this medication cause?

Dostarlimab-gxly injection, like many medications, can cause side effects, although not everyone experiences them. Common side effects of Dostarlimab-gxly injection may include:

• Fatigue
• Nausea
• Diarrhea
• Rash
• Itching
• Decreased appetite
• Constipation
• Cough
• Shortness of breath
• Headache
• Muscle or joint pain
• Abdominal pain
• Fever
• Changes in thyroid hormone levels
• Elevated liver enzymes

These side effects are usually mild to moderate in severity and may improve over time as your body adjusts to the medication. However, some individuals may experience more serious side effects that require medical attention. These may include:

• Severe allergic reactions: Symptoms may include rash, itching, difficulty breathing, swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience any signs of a severe allergic reaction.
• Immune-related adverse events (irAEs): Dostarlimab-gxly works by boosting the immune system, which can sometimes lead to the immune system attacking normal tissues and organs. This can cause inflammation in various parts of the body, such as the lungs (pneumonitis), intestines (colitis), liver (hepatitis), hormone glands (endocrinopathies), or skin (dermatitis). These side effects can be serious and require prompt medical evaluation and management.
• Infections: Dostarlimab-gxly can suppress the immune system, increasing the risk of infections. Contact your healthcare provider if you develop signs or symptoms of an infection, such as fever, chills, cough, sore throat, difficulty breathing, or unusual tiredness.

It’s important to discuss any side effects or concerns with your healthcare provider, as they can provide guidance on managing side effects and adjusting your treatment plan if necessary. Additionally, report any new or worsening symptoms to your healthcare provider promptly, as they may indicate a serious adverse reaction that requires medical attention.

What should I know about storage and disposal of this medication?

Storage and disposal of Dostarlimab-gxly Injection:

• Storage: Dostarlimab-gxly Injection should be stored in its original packaging at the recommended temperature as specified on the label. It is typically stored refrigerated but may be allowed to reach room temperature before use. Do not freeze. Keep it out of reach of children and pets.
• Disposal: Any unused or expired Dostarlimab-gxly Injection should be disposed of properly according to local regulations or guidelines. Do not dispose of it in household trash or flush it down the toilet unless instructed to do so. Contact your healthcare provider, pharmacist, or local waste disposal facility for instructions on how to safely dispose of the medication.

In case of emergency/overdose

In case of an emergency or overdose with Dostarlimab-gxly Injection, seek immediate medical attention or contact a poison control center. It’s essential to have emergency contact information readily available, such as the number for your healthcare provider or local emergency services.

What other information should I know?

• Other Information: Before starting treatment with Dostarlimab-gxly Injection, inform your healthcare provider about any medical conditions you have, including allergies, current medications you are taking (including prescription and over-the-counter drugs, vitamins, and supplements), and any previous treatments or surgeries you have undergone. Follow all instructions provided by your healthcare provider regarding the dosage, administration, and monitoring of Dostarlimab-gxly Injection. Attend all scheduled appointments for follow-up monitoring and evaluation of your response to treatment.
• Monitoring: Your healthcare provider will monitor you closely during treatment with Dostarlimab-gxly Injection for any signs of side effects or complications. Be sure to report any new or worsening symptoms to your healthcare provider promptly. It’s essential to communicate openly with your healthcare team and ask any questions or express any concerns you may have throughout the course of treatment.

By following these guidelines and staying informed about the proper storage, disposal, and emergency procedures related to Dostarlimab-gxly Injection, you can help ensure safe and effective use of the medication as part of your cancer treatment regimen.