Why is this medication prescribed?

Capmatinib is a medication prescribed for the treatment of a specific type of lung cancer known as metastatic non-small cell lung cancer (NSCLC) that has a mutation in the mesenchymal-epithelial transition (MET) gene. This mutation leads to the MET exon 14 skipping alteration, which can drive the growth of cancer cells.

How should this medicine be used?

Here’s how Capmatinib is typically used:

• Dosage: The dosage of Capmatinib can vary based on individual patient factors and should be determined by a healthcare provider. It is usually taken orally in the form of tablets.
• Administration: Capmatinib tablets are generally taken with food to help with absorption and reduce the likelihood of gastrointestinal side effects.
• Duration: Treatment with Capmatinib is usually continued as long as it is effective and tolerated by the patient. Regular monitoring by a healthcare provider is essential to assess the response to treatment and manage any potential side effects.
• Follow-up: Patients prescribed Capmatinib should follow their healthcare provider’s instructions carefully regarding dosage and timing of administration. It’s important not to adjust the dosage or stop taking the medication without consulting a healthcare provider.
• Special Instructions: Certain medications or supplements may interact with Capmatinib, so it’s crucial to inform healthcare providers about all medications and supplements being taken.

Overall, Capmatinib is a targeted therapy designed to specifically inhibit the activity of the abnormal MET protein in cancer cells, thereby slowing down or stopping the growth and spread of metastatic NSCLC with MET exon 14 skipping alterations.

Other uses for this medicine

Capmatinib is primarily used for the treatment of metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping alterations. Currently, its use is specifically indicated for this condition. However, as research continues and new clinical trials emerge, there may be exploration into other potential uses for Capmatinib in different types of cancers or conditions related to the MET pathway.

What special precautions should I follow?

Regarding special precautions for Capmatinib, here are important considerations:

• Medical History: Before starting Capmatinib, it’s essential to inform your healthcare provider about your complete medical history, especially if you have any liver problems, lung disease, or other medical conditions.
• Pregnancy and Breastfeeding: Capmatinib can cause harm to an unborn baby if used during pregnancy. Therefore, it is crucial to use effective contraception during treatment and avoid becoming pregnant. Additionally, it is not known whether Capmatinib passes into breast milk, so breastfeeding should be avoided during treatment and for a period after the last dose.
• Liver Function: Capmatinib can affect liver function, so regular monitoring of liver enzymes and function tests is typically recommended during treatment. Your healthcare provider may adjust your dose or temporarily stop treatment if liver enzyme levels become elevated.
• Interstitial Lung Disease (ILD) or Pneumonitis: Capmatinib can cause ILD or pneumonitis, which are serious lung problems. Patients should be monitored for new or worsening symptoms such as difficulty breathing, cough, or fever. Treatment may need to be interrupted or discontinued if ILD or pneumonitis occurs.
• Eye Disorders: Capmatinib may cause eye problems such as vision changes or eye swelling. Patients should report any new or worsening eye symptoms to their healthcare provider.
• Other Medications: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as Capmatinib may interact with other drugs.
• Routine Monitoring: Regular monitoring of blood counts, liver function tests, and other laboratory parameters may be necessary during treatment with Capmatinib to manage potential side effects and assess treatment response.

Always follow your healthcare provider’s instructions regarding the use of Capmatinib and report any concerns or side effects promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Capmatinib. However, taking Capmatinib with food can help with absorption and reduce the likelihood of gastrointestinal side effects. It’s generally recommended to take Capmatinib tablets with a meal or snack unless otherwise instructed by your healthcare provider.

What should I do if I forget a dose?

If you miss a dose of Capmatinib, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and take your regular dose at the scheduled time. Do not take extra medicine to make up for a missed dose.

What side effects can this medication cause?

Capmatinib, like any medication, can cause side effects. Some of the common and potentially serious side effects associated with Capmatinib include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, constipation, and abdominal pain are common side effects. Taking Capmatinib with food can help reduce these symptoms.
• Liver Function Abnormalities: Elevated liver enzymes (ALT, AST) and bilirubin levels can occur, which may indicate liver problems. Regular monitoring of liver function tests is necessary during treatment.
• Interstitial Lung Disease (ILD) or Pneumonitis: This is a serious side effect characterized by inflammation in the lungs, which can cause symptoms such as cough, difficulty breathing, and fever. Prompt medical attention is required if these symptoms develop.
• Edema (Fluid Retention): Swelling in the hands, feet, ankles, or other parts of the body can occur due to fluid retention.
• Fatigue: Feeling tired or weak is a common side effect of Capmatinib.
• Musculoskeletal Effects: Muscle or joint pain, as well as muscle weakness, can occur.
• Eye Disorders: Capmatinib may cause vision changes or eye swelling. Inform your healthcare provider about any new or worsening eye symptoms.
• Skin Reactions: Rash, itching, dry skin, and hair color changes are possible.
• Kidney Problems: Changes in kidney function, including increased creatinine levels, have been reported.
• Cardiovascular Effects: Palpitations (irregular heartbeat) and hypertension (high blood pressure) can occur.
• Other Side Effects: Headache, fever, decreased appetite, and changes in taste sensation are less common but possible.

It’s important to note that not all individuals will experience these side effects, and some may experience them to varying degrees of severity. Your healthcare provider will monitor you closely for any side effects during treatment with Capmatinib. If you experience any concerning symptoms or side effects, it’s crucial to report them promptly to your healthcare provider for evaluation and management.

What should I know about storage and disposal of this medication?

Storage and Disposal of Capmatinib:

• Storage: Capmatinib tablets should be stored at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect from moisture: Keep the tablets in their original packaging and protect from moisture.
• Keep out of reach: Store Capmatinib in a secure place away from children and pets.
• Do not use expired medication: Check the expiration date on the packaging and do not use Capmatinib if it has expired.

In case of emergency/overdose

• Seek immediate medical attention: Contact your local emergency services or go to the nearest emergency room.
• Symptoms: Overdose symptoms may include severe gastrointestinal symptoms (such as vomiting or diarrhea), liver function abnormalities, and potential exacerbation of other known side effects.
• Inform healthcare provider: Provide information about the amount of Capmatinib taken and any symptoms experienced.

What other information should I know?

• Regular Monitoring: Your healthcare provider will monitor your response to Capmatinib and assess for any side effects or complications. This may involve regular blood tests, imaging studies, and clinical evaluations.
• Follow-up appointments: Attend all scheduled appointments with your healthcare provider for ongoing assessment and management of your condition.
• Medication adherence: Take Capmatinib exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider first.
• Drug interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking to avoid potential interactions with Capmatinib.
• Pregnancy and breastfeeding: Capmatinib can cause harm to unborn babies, so effective contraception should be used during treatment and breastfeeding should be avoided.
• Handling tablets: Handle Capmatinib tablets with care and wash hands thoroughly after handling.

Always keep the contact information for your healthcare provider and pharmacy readily available in case you have questions or need assistance related to Capmatinib.