WARNING

Camzyos (Generic Mavacamten) is a medication primarily used to treat hypertrophic cardiomyopathy (HCM), a condition where the heart muscle becomes abnormally thick. While effective, like any medication, Camzyos carries certain risks:

• Side Effects: Common side effects may include headache, dizziness, nausea, and fatigue. These are usually mild but can affect quality of life.
• Cardiovascular Effects: Due to its action on the heart muscle, Camzyos can lead to changes in heart rhythm (arrhythmias) or exacerbate existing cardiovascular conditions. Monitoring by a healthcare provider is essential.
• Liver Function: There is a potential risk of liver enzyme elevation, which may require monitoring through blood tests.
• Interactions: Camzyos may interact with other medications or supplements, potentially altering their effectiveness or increasing side effects.
• Allergic Reactions: While rare, allergic reactions such as rash, itching, swelling, or difficulty breathing can occur and require immediate medical attention.
• Pregnancy and Breastfeeding: Safety during pregnancy and breastfeeding is not well-established, and caution is advised.
• Kidney Function: In some cases, Camzyos can affect kidney function, especially in individuals with pre-existing kidney disease.
• Long-Term Effects: Since Camzyos is a relatively new medication, its long-term effects on various organs and systems are still being studied.

It’s crucial for patients taking Camzyos to communicate openly with their healthcare provider, adhere strictly to prescribed dosages, and attend regular follow-up appointments to monitor for any developing issues or side effects.

Why is this medication prescribed?

Camzyos is primarily prescribed to treat hypertrophic cardiomyopathy (HCM), a genetic heart condition where the heart muscle becomes abnormally thick. This thickening can make it harder for the heart to pump blood effectively, leading to symptoms such as shortness of breath, chest pain, fatigue, and in severe cases, heart failure. Camzyos works by inhibiting the enzyme myosin ATPase, which reduces the excessive contraction of the heart muscle and helps to improve its function.

How should this medicine be used?

Camzyos is typically taken orally as a tablet. The dosage and frequency will be determined by the prescribing healthcare provider based on individual factors such as the severity of the condition, other medications being taken, and overall health. Generally, the starting dose is low and gradually increased over time to achieve optimal therapeutic effect while minimizing side effects.

Here are some general guidelines for using Camzyos:

• Follow Prescribed Instructions: Always follow the exact dosing instructions provided by your healthcare provider. Do not change the dose or stop taking Camzyos without consulting your doctor.
• Take with or without Food: Camzyos can be taken with or without food. It’s important to take it consistently in relation to meals to maintain steady blood levels.
• Regular Monitoring: Your doctor will likely schedule regular follow-up appointments to monitor your response to Camzyos and check for any side effects or changes in your condition. This may include blood tests and cardiac evaluations.
• Missed Doses: If you miss a dose of Camzyos, take it as soon as you remember, unless it is close to the time of your next scheduled dose. Do not double up on doses to make up for a missed one.
• Storage: Camzyos should be stored at room temperature, away from moisture and heat. It should be kept in its original container or packaging to protect it from light and humidity. Make sure to keep Camzyos out of reach of children and pets.

If you have any specific questions about how to use Camzyos or concerns about its storage, always consult your healthcare provider or pharmacist for guidance tailored to your situation.

Other uses for this medicine

Currently, there are no other approved uses for Camzyos beyond its indication for HCM. It is essential to use Camzyos only as prescribed by your healthcare provider and for the specific condition it is intended to treat.

What special precautions should I follow?

Special Precautions for Camzyos:

• Liver Function: Camzyos may cause elevated liver enzymes in some individuals. Regular monitoring of liver function through blood tests is recommended during treatment.
• Heart Rhythm: Due to its effects on heart muscle contraction, Camzyos may affect heart rhythm (arrhythmias). Patients with pre-existing arrhythmias or other cardiovascular conditions should be closely monitored by a healthcare provider.
• Drug Interactions: Inform your doctor about all medications, vitamins, and supplements you are taking before starting Camzyos. Some medications may interact with Camzyos, affecting its effectiveness or increasing the risk of side effects.
• Pregnancy and Breastfeeding: The safety of Camzyos during pregnancy and breastfeeding has not been established. It should only be used during pregnancy if clearly needed and after consultation with a healthcare provider.
• Kidney Function: Camzyos may affect kidney function in some individuals, especially those with pre-existing kidney disease. Regular monitoring of kidney function may be necessary during treatment.
• Allergic Reactions: If you have a known allergy to Camzyos or any of its components, inform your doctor before starting treatment. Allergic reactions can range from mild (e.g., rash) to severe (e.g., difficulty breathing), requiring immediate medical attention.
• Driving and Operating Machinery: Camzyos may cause dizziness or fatigue as side effects. If you experience these symptoms, avoid driving or operating machinery until you know how Camzyos affects you.
• Follow-up Care: Attend all scheduled appointments with your healthcare provider for monitoring of your condition and response to Camzyos. This helps ensure the medication is working effectively and safely for you.

Always discuss any concerns or questions about Camzyos with your healthcare provider. They can provide personalized guidance based on your medical history and individual circumstances.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Camzyos. However, maintaining a healthy diet as recommended by your healthcare provider is beneficial for overall cardiovascular health. If you have any concerns about diet and medication interactions, discuss them with your doctor or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Camzyos, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Camzyos (Generic Mavacamten) can cause various side effects, although not everyone experiences them. Common side effects include:

• Headache: Mild to moderate headaches can occur.
• Nausea: Some people may experience feelings of nausea.
• Dizziness: Feeling lightheaded or dizzy may occur, especially when standing up quickly.
• Fatigue: Feeling tired or fatigued is a common side effect.
• Abdominal Pain: Some individuals may experience abdominal discomfort.
• Diarrhea: Loose stools or diarrhea can occur in some cases.
• Muscle Pain: Muscular discomfort or pain may occur.
• Abnormal Liver Function Tests: Camzyos can sometimes cause elevated liver enzymes, which would be detected through blood tests.

Less common but potentially more serious side effects include:

• Arrhythmias: Changes in heart rhythm may occur, which could manifest as palpitations or irregular heartbeat.
• Allergic Reactions: Rarely, allergic reactions such as rash, itching, swelling of the face/tongue/throat, severe dizziness, or trouble breathing may occur. These require immediate medical attention.

It’s important to discuss any concerns about side effects with your healthcare provider. They can provide guidance on managing side effects and determine if any adjustments to your treatment plan are necessary. If you experience severe or persistent side effects, contact your healthcare provider promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal of Camzyos:

• Storage: Keep Camzyos tablets in the original container at room temperature, away from moisture and heat. Avoid storing them in the bathroom or in places where they could get wet. Keep Camzyos out of reach of children and pets.
• Disposal: If you have unused or expired Camzyos tablets, it’s important to dispose of them properly to prevent accidental ingestion. You can check with your pharmacist or local waste disposal company for guidelines on how to safely dispose of medications.

In case of emergency/overdose

• Emergency: If you suspect an overdose or have any serious symptoms such as severe dizziness, fainting, irregular heartbeat, or difficulty breathing, seek immediate medical attention or call your local emergency services (such as 911 in the United States).
• Overdose: There is limited information available about specific overdose symptoms with Camzyos. However, if you accidentally take more than the prescribed dose, contact your healthcare provider or go to the nearest emergency room for evaluation and management.

What other information should I know?

• Monitoring: Regular follow-up appointments with your healthcare provider are important to monitor your response to Camzyos and check for any potential side effects or changes in your condition.
• Compliance: Take Camzyos exactly as prescribed by your healthcare provider. Do not adjust your dose or stop taking the medication without consulting your doctor.
• Medication Interactions: Inform your doctor about all other medications, vitamins, and supplements you are taking, as Camzyos may interact with other drugs.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Camzyos during pregnancy and breastfeeding has not been established.
• Driving and Machinery: Camzyos may cause dizziness or fatigue as side effects. Avoid driving or operating machinery if you experience these symptoms.
• Allergic Reactions: If you have a known allergy to Camzyos or its components, inform your healthcare provider before starting treatment.

Always keep your healthcare provider informed about any changes in your health or any new symptoms you experience while taking Camzyos. They can provide personalized advice and guidance based on your medical history and current condition.