WARNING

Belzutifan is a medication used to treat certain types of cancer by blocking a specific protein involved in tumor growth. While it can be effective, like any medication, it carries potential risks. Some common side effects include nausea, diarrhea, fatigue, and elevated liver enzymes. More serious risks may include high blood pressure, bleeding, or impaired wound healing. It’s essential to discuss all potential risks and benefits with your healthcare provider before starting this medication. Regular monitoring and communication with your healthcare team can help manage these risks effectively.

Why is this medication prescribed?

Belzutifan is a medication prescribed for the treatment of certain types of tumors associated with von Hippel-Lindau (VHL) disease, a rare genetic disorder. It belongs to a class of drugs known as hypoxia-inducible factor (HIF) inhibitors. Belzutifan works by blocking the activity of HIF-2α, a protein that plays a role in promoting the growth and spread of tumors.

How should this medicine be used?

Belzutifan is typically taken orally, usually once daily, with or without food. The dosage and duration of treatment may vary depending on the individual’s medical condition and response to the medication. It’s important to follow the dosage instructions provided by your healthcare provider. Additionally, it’s essential to inform your doctor about any other medications or supplements you are taking before starting Belzutifan, as it may interact with other drugs.

As with any prescription medication, it’s crucial to take Belzutifan exactly as prescribed by your healthcare provider and to not adjust the dosage or stop taking it without consulting your doctor first. If you have any questions or concerns about how to use Belzutifan, it’s best to discuss them with your healthcare provider.

Other uses for this medicine

Belzutifan is primarily used for the treatment of certain tumors associated with von Hippel-Lindau (VHL) disease, as mentioned earlier. However, researchers are continually exploring potential additional uses for this medication in the treatment of other types of cancers and related conditions. Clinical trials may investigate its efficacy in various tumor types and disease contexts.

What special precautions should I follow?

Regarding special precautions for Belzutifan, it’s essential to follow your healthcare provider’s guidance closely. Here are some general precautions to consider:

• Medical History: Inform your doctor about your complete medical history, including any allergies, pre-existing conditions, or medications you are currently taking. This information will help your doctor assess whether Belzutifan is suitable for you.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Belzutifan with your doctor. The safety of this medication during pregnancy and breastfeeding has not been established, so caution is advised.
• Liver and Kidney Function: Belzutifan may affect liver and kidney function. Your doctor may monitor your liver and kidney function through blood tests while you are taking this medication.
• Interactions: Inform your doctor about all the medications, supplements, and herbal products you are currently taking. Some medications may interact with Belzutifan, potentially affecting its effectiveness or increasing the risk of side effects.
• Side Effects: Be aware of the potential side effects of Belzutifan, which may include nausea, vomiting, diarrhea, fatigue, headache, high blood pressure, and changes in blood electrolyte levels. If you experience any severe or persistent side effects, contact your doctor promptly.
• Driving and Operating Machinery: Belzutifan may cause dizziness or fatigue. Avoid driving, operating machinery, or engaging in activities that require alertness until you know how this medication affects you.
• Regular Follow-up: Attend all scheduled appointments with your doctor for monitoring and follow-up assessments. Regular check-ups are essential to evaluate the effectiveness of the treatment and monitor for any potential adverse effects.

Always consult your healthcare provider for personalized advice and recommendations regarding the use of Belzutifan, as individual circumstances may vary.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Belzutifan. However, it’s essential to maintain a balanced and healthy diet as recommended by your healthcare provider. If you have any concerns about your diet or nutrition while taking Belzutifan, consult your doctor or a registered dietitian for personalized advice.

What should I do if I forget a dose?

If you miss a dose of Belzutifan, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you are unsure about what to do, or if you have missed multiple doses, contact your healthcare provider or pharmacist for advice. They can provide guidance on how to proceed based on your specific situation.

What side effects can this medication cause?

Belzutifan, like any medication, can cause side effects. Not everyone experiences these side effects, and their severity can vary from person to person. Common side effects of Belzutifan may include:

• Nausea and vomiting: Feeling sick to your stomach or vomiting.
• Diarrhea: Frequent, loose, or watery bowel movements.
• Fatigue: Feeling tired or lacking energy.
• Headache: Pain or discomfort in the head, ranging from mild to severe.
• Increased blood pressure: Belzutifan can sometimes cause a rise in blood pressure, which may require monitoring and management.
• Changes in blood electrolyte levels: Belzutifan may affect the levels of certain electrolytes in the blood, such as potassium, sodium, and calcium.
• Decreased appetite: A reduced desire to eat or feeling less hungry than usual.
• Constipation: Difficulty passing stools or having infrequent bowel movements.

These side effects are not necessarily experienced by everyone taking Belzutifan, and some individuals may experience additional or different side effects. It’s essential to report any side effects you experience to your healthcare provider, especially if they are severe, persistent, or concerning.

In some cases, Belzutifan can cause serious side effects that require immediate medical attention. These may include:

• Allergic reactions: Symptoms may include rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing, or severe dizziness. Seek emergency medical attention if you experience signs of an allergic reaction.
• Severe hypertension: Belzutifan can sometimes cause a significant increase in blood pressure, which may require urgent medical treatment.
• Severe liver or kidney problems: In rare cases, Belzutifan may cause severe liver or kidney damage. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, swelling of the abdomen, or changes in urination pattern.
• Other serious side effects: These may include severe diarrhea or dehydration, electrolyte imbalances, or worsening of pre-existing conditions.

If you experience any serious or concerning side effects while taking Belzutifan, seek medical attention immediately. Your healthcare provider can assess your symptoms and determine the appropriate course of action.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Belzutifan:

• Storage: Store Belzutifan tablets at room temperature away from light and moisture. Keep the medication in its original packaging and out of reach of children and pets.
• Disposal: Dispose of unused or expired Belzutifan tablets properly according to local regulations or guidelines. Do not flush them down the toilet or pour them into a drain unless instructed to do so. You can consult your pharmacist or healthcare provider for guidance on safe disposal methods.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms after taking Belzutifan, such as severe hypertension, allergic reactions, or any other serious side effects, seek immediate medical attention or contact your local poison control center. You can also call emergency services for assistance. Be sure to provide as much information as possible about the medication you have taken, including the dosage and when it was ingested.

What other information should I know?

• Regular Monitoring: Your healthcare provider may require regular monitoring of your liver and kidney function, as well as blood pressure and electrolyte levels, while you are taking Belzutifan.
• Follow-up Appointments: Attend all scheduled follow-up appointments with your doctor to assess the effectiveness of the treatment and monitor for any potential side effects or complications.
• Medication Compliance: Take Belzutifan exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your doctor first.
• Drug Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as they may interact with Belzutifan. Your doctor can advise you on potential interactions and adjust your treatment regimen accordingly.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Belzutifan with your doctor. The safety of this medication during pregnancy and breastfeeding is not well established.
• Driving and Operating Machinery: Belzutifan may cause dizziness or fatigue. Avoid driving, operating machinery, or engaging in activities that require alertness until you know how this medication affects you.

Always follow your healthcare provider’s instructions and recommendations regarding the use of Belzutifan, and consult them if you have any questions or concerns.