WARNING

Deferasirox is a medication used to remove excess iron from the body, particularly in patients who receive frequent blood transfusions. While it’s generally effective, like any medication, it carries certain risks. Some potential risks of taking Deferasirox include:

• Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, and abdominal pain. These symptoms can range from mild to severe and may require medical attention.
• Renal Toxicity: Deferasirox has been associated with kidney problems, including renal failure. It’s important for patients to have regular monitoring of kidney function while taking this medication.
• Liver Toxicity: Rare cases of liver damage have been reported with Deferasirox use. Patients may experience elevated liver enzymes or jaundice, indicating liver problems.
• Auditory and Ocular Disturbances: Some individuals may experience changes in hearing or vision while taking Deferasirox. Regular monitoring of auditory and ocular function is recommended.
• Skin Reactions: Allergic reactions, including severe skin rashes such as Stevens-Johnson syndrome, have been reported with Deferasirox use. Patients should seek medical attention if they develop any unusual skin symptoms.
• Electrolyte Imbalance: Deferasirox can affect electrolyte levels in the body, leading to conditions such as hypokalemia (low potassium) or hypomagnesemia (low magnesium). Monitoring of electrolytes is essential during treatment.
• Bone Marrow Suppression: Rarely, Deferasirox may cause bone marrow suppression, resulting in decreased production of blood cells. Symptoms may include fatigue, weakness, and increased susceptibility to infections.
• Interactions with Other Medications: Deferasirox may interact with other drugs, potentially leading to adverse effects or reduced efficacy. Patients should inform their healthcare provider about all medications they are taking.
• Fertility and Pregnancy: The effects of Deferasirox on fertility and pregnancy are not fully understood. It’s essential for women of childbearing age to use effective contraception while taking this medication.
• Long-term Safety: Because Deferasirox is a relatively new medication, its long-term safety profile is still being studied. Patients should be aware that additional risks may emerge with prolonged use.

Overall, while Deferasirox can effectively manage iron overload, patients should be closely monitored for potential adverse effects, and any concerning symptoms should be promptly reported to a healthcare professional.

Why is this medication prescribed?

Deferasirox is prescribed primarily for the treatment of iron overload in patients who receive regular blood transfusions, such as those with certain types of anemia, like thalassemia or sickle cell disease. Iron overload can lead to organ damage over time, so removing excess iron from the body is crucial for these patients.

Deferasirox is an oral medication usually taken once daily. The dosage prescribed by a healthcare provider depends on factors such as the patient’s age, weight, underlying condition, and severity of iron overload. It’s typically taken on an empty stomach, at least 30 minutes before food, to enhance absorption.

How should this medicine be used?

Here are some general guidelines for using Deferasirox:

• Dosage: Follow your healthcare provider’s instructions regarding the dosage and frequency of Deferasirox. Do not alter the dosage without consulting your doctor.
• Administration: Swallow the tablet whole with water. Do not crush, chew, or break the tablet, as it may affect the medication’s effectiveness and increase the risk of side effects.
• Timing: Take Deferasirox at the same time each day to maintain consistent levels of the medication in your body.
• Monitoring: Your healthcare provider will regularly monitor your iron levels, kidney function, liver function, and other relevant parameters while you’re taking Deferasirox. Attend all scheduled appointments and inform your doctor of any concerning symptoms.
• Adherence: It’s essential to take Deferasirox exactly as prescribed, even if you feel well. Missing doses or stopping the medication abruptly can lead to inadequate iron removal and potential complications.
• Storage: Store Deferasirox tablets at room temperature away from moisture and heat. Keep the medication out of reach of children and pets.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you’re taking, as some substances may interact with Deferasirox, affecting its efficacy or increasing the risk of side effects.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Deferasirox with your healthcare provider. They will help you make an informed decision regarding its use during pregnancy or lactation.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about using Deferasirox.

Other uses for this medicine

Apart from treating iron overload due to blood transfusions, Deferasirox may have potential off-label uses or investigational uses in conditions associated with iron accumulation, such as hereditary hemochromatosis. However, the use of Deferasirox for these purposes would be at the discretion of the prescribing physician and based on individual patient needs.

What special precautions should I follow?

Regarding special precautions for Deferasirox, it’s crucial to adhere to the following guidelines:

• Regular Monitoring: Your healthcare provider will regularly monitor your iron levels, kidney function, liver function, and other relevant parameters while you’re taking Deferasirox. Attend all scheduled appointments and inform your doctor of any concerning symptoms.
• Kidney Function: Deferasirox can cause kidney problems, so it’s essential to have regular monitoring of kidney function, including serum creatinine levels and urine protein tests. Your healthcare provider may adjust your dosage based on your kidney function.
• Liver Function: Liver function tests should be performed periodically to monitor for any signs of liver damage. If you experience symptoms such as jaundice, abdominal pain, or unusual fatigue, notify your healthcare provider immediately.
• Auditory and Ocular Function: Report any changes in hearing or vision to your healthcare provider, as Deferasirox may rarely cause auditory or ocular disturbances.
• Adherence to Dosage Instructions: Take Deferasirox exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting them first.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Deferasirox with your healthcare provider. They will help you make an informed decision regarding its use during pregnancy or lactation.

By following these precautions and guidelines, you can help ensure the safe and effective use of Deferasirox as prescribed by your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Deferasirox. However, it’s generally recommended to maintain a balanced diet and stay hydrated while taking the medication. Your healthcare provider may advise you to avoid excessive consumption of alcohol, which can exacerbate potential liver problems.

What should I do if I forget a dose?

If you forget to take a dose of Deferasirox, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance. It’s important to maintain consistency in taking Deferasirox to ensure its effectiveness in managing iron overload.

What side effects can this medication cause?

Deferasirox, like any medication, can cause side effects. Common side effects of Deferasirox may include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal pain are common side effects. These symptoms may improve over time as your body adjusts to the medication.
• Renal Toxicity: Deferasirox can affect kidney function, leading to kidney problems such as increased serum creatinine levels, proteinuria (protein in the urine), and kidney damage. Regular monitoring of kidney function is essential.
• Liver Toxicity: Rare cases of liver damage, indicated by elevated liver enzymes or jaundice, have been reported with Deferasirox use. If you experience symptoms such as abdominal pain, yellowing of the skin or eyes (jaundice), or unusual fatigue, seek medical attention promptly.
• Auditory and Ocular Disturbances: Some individuals may experience changes in hearing or vision while taking Deferasirox. This can include ringing in the ears (tinnitus), hearing loss, or visual disturbances. Notify your healthcare provider if you notice any changes in your auditory or visual function.
• Skin Reactions: Allergic reactions, including severe skin rashes such as Stevens-Johnson syndrome or toxic epidermal necrolysis, have been reported with Deferasirox use. Seek medical attention immediately if you develop a rash, blistering, or peeling of the skin, as these can be signs of a serious allergic reaction.
• Electrolyte Imbalance: Deferasirox can affect electrolyte levels in the body, leading to conditions such as hypokalemia (low potassium), hypomagnesemia (low magnesium), or hypophosphatemia (low phosphate). Monitoring of electrolytes is important during treatment.
• Bone Marrow Suppression: Rarely, Deferasirox may cause bone marrow suppression, resulting in decreased production of blood cells. This can lead to symptoms such as fatigue, weakness, and increased susceptibility to infections.
• Other Side Effects: Other less common side effects of Deferasirox may include headache, dizziness, fever, and musculoskeletal pain.

It’s important to report any unusual or persistent symptoms to your healthcare provider while taking Deferasirox. They can help determine whether any side effects require medical attention or adjustments to your treatment regimen.

What should I know about storage and disposal of this medication?

Storage and disposal of Deferasirox:

Storage:

• Store Deferasirox tablets at room temperature, away from moisture and heat.
• Keep the medication in its original packaging or container, tightly closed.
• Store Deferasirox out of reach of children and pets.

Disposal:

• Dispose of unused or expired Deferasirox tablets properly according to local regulations or guidelines.
• Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
• Consult your pharmacist or local waste disposal authority for information on proper disposal methods.

In case of emergency/overdose

• In case of an overdose of Deferasirox, seek emergency medical attention or contact a poison control center immediately.
• Symptoms of an overdose may include severe gastrointestinal symptoms (e.g., vomiting, diarrhea), kidney problems, liver damage, electrolyte imbalances, and other adverse effects.
• Be prepared to provide information about the amount of Deferasirox ingested, the timing of ingestion, and any symptoms experienced.

What other information should I know?

• Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Deferasirox, as some substances may interact with it.
• Attend all scheduled medical appointments for monitoring of iron levels, kidney function, liver function, and other relevant parameters.
• Notify your healthcare provider of any new or worsening symptoms while taking Deferasirox, as they may require adjustments to your treatment plan.
• Follow your healthcare provider’s instructions carefully regarding dosage, administration, and dietary recommendations while taking Deferasirox.
• Keep Deferasirox and all medications out of sight and reach of children and pets to prevent accidental ingestion.
• Do not share Deferasirox with others, even if they have similar symptoms or conditions, as it may not be appropriate for their situation.

By following these guidelines, you can ensure the safe storage, disposal, and use of Deferasirox while minimizing the risk of adverse effects and complications.