Why is this medication prescribed?

Bevacizumab injection products are used in conjunction with other chemotherapy drugs to treat specific types of cancer that start in the large intestine and colon, non-small cell lung cancer (NSCLC), glioblastoma (a specific kind of brain tumor), renal cell cancer (RCC), cervical cancer (a cancer that starts in the opening of the uterus [womb]), ovarian (the female reproductive organs where the eggs are formed), fallopian tube (the tube that carries the eggs released by the ovaries to the uterus), or peritoneal (a layer of tissue lining the abdomen) cancer.Additionally, atezolizumab (Tecentriq) and bevacizumab (Avastin) are used in tandem to treat hepatocellular carcinoma (HCC) that has spread or is not surgically resectable.

In patients who have not previously had chemotherapy, bevacizumab (Avastin) and atezolizumab (Tecentriq) are also used in conjunction to treat hepatocellular carcinoma (HCC) that has spread or cannot be removed surgically. Bevacizumab injection products are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.

How should this medicine be used?

Bevacizumab injection is typically administered by a healthcare professional in a clinical setting, such as a hospital or doctor’s office. The specific dosage and administration schedule depend on various factors, including the type of cancer being treated, the patient’s overall health, and other medications they may be taking.

Here are some general guidelines for the use of Bevacizumab injection:

• Administration: Bevacizumab is usually given as an intravenous infusion, which means it is injected directly into a vein. The infusion is typically delivered over a period of time, often ranging from 30 minutes to several hours. The healthcare provider will determine the appropriate infusion rate based on the patient’s condition and tolerance.
• Dosage: The dosage of Bevacizumab can vary depending on factors such as the type of cancer being treated and the patient’s body weight. It is important to follow the prescribing doctor’s instructions regarding the dosage and schedule of administration.
• Frequency: Bevacizumab is often administered on a regular schedule, such as once every two or three weeks. The frequency of treatment may vary depending on the specific treatment regimen prescribed by the doctor.
• Monitoring: During treatment with Bevacizumab, patients will typically undergo regular monitoring to assess their response to therapy and monitor for any potential side effects. This may involve blood tests, imaging studies, and physical examinations.
• Duration: The duration of treatment with Bevacizumab can vary depending on factors such as the type and stage of cancer, the patient’s response to therapy, and other treatment modalities being used. Some patients may receive Bevacizumab for a limited course of treatment, while others may continue treatment for a longer period of time.

It’s important for patients to communicate openly with their healthcare providers throughout the course of treatment, reporting any side effects or concerns they may experience. Additionally, patients should follow any additional instructions provided by their doctor regarding pre-treatment preparations or post-treatment care.

Other uses for this medicine

In addition to its primary use in treating various types of cancer, Bevacizumab injection may also be used in certain other medical conditions, although such uses would be prescribed off-label and should be discussed thoroughly with a healthcare provider. Off-label use might include conditions like age-related macular degeneration (AMD), diabetic retinopathy, and macular edema.

What special precautions should I follow?

Special precautions should be observed when using Bevacizumab injection due to its potential for serious side effects and interactions with other medications. Here are some important precautions to consider:

• Risk of Bleeding: Bevacizumab can increase the risk of bleeding, which can be serious or even fatal. Patients with a history of bleeding disorders or those taking anticoagulant medications should be closely monitored during treatment.
• Hypertension: Bevacizumab may cause high blood pressure (hypertension). Blood pressure should be monitored regularly during treatment, and antihypertensive medications may be prescribed if necessary.
• GI Perforation: There is a risk of gastrointestinal (GI) perforation (a hole in the stomach, intestine, or bowel) associated with Bevacizumab use. Patients with a history of GI perforation or those at increased risk should use Bevacizumab with caution.
• Wound Healing: Bevacizumab may impair wound healing, which can be problematic before or after surgery. It’s essential to inform healthcare providers about Bevacizumab treatment before undergoing any surgical procedures.
• Heart Problems: Bevacizumab may increase the risk of heart problems such as heart attack or heart failure. Patients with pre-existing heart conditions should be closely monitored during treatment.
• Proteinuria: Bevacizumab can cause proteinuria (protein in the urine), which may indicate kidney damage. Regular monitoring of kidney function is recommended during treatment.
• Pregnancy and Breastfeeding: Bevacizumab can harm the unborn baby and should not be used during pregnancy unless the potential benefits outweigh the risks. It is also not recommended for use while breastfeeding.
• Allergic Reactions: Patients should be monitored for signs of allergic reactions during and after Bevacizumab infusion. Symptoms may include difficulty breathing, swelling of the face or throat, rash, or itching.
• Immunizations: Live vaccines should not be administered during treatment with Bevacizumab due to the risk of infection. Inactivated vaccines may be less effective during treatment.

It’s crucial for patients to discuss their medical history, including any existing health conditions and medications they are taking, with their healthcare provider before starting treatment with Bevacizumab. Open communication and close monitoring can help mitigate risks and ensure safe and effective treatment.

What special dietary instructions should I follow?

Regarding special dietary instructions for Bevacizumab Injection, there are no specific dietary restrictions associated with its use. However, maintaining a balanced and nutritious diet can support overall health and well-being during cancer treatment. It’s essential to stay hydrated and consume a variety of foods rich in vitamins, minerals, and antioxidants to support your body’s immune system and energy levels.

What should I do if I forget a dose?

If you forget a dose of Bevacizumab Injection, it’s important to contact your healthcare provider or treatment facility as soon as possible for guidance. Depending on the circumstances and your treatment plan, your healthcare provider may recommend rescheduling the missed dose or adjusting your treatment schedule. Do not try to administer the missed dose yourself or double up on doses without consulting your healthcare provider, as this can increase the risk of side effects and complications.

What side effects can this medication cause?

Bevacizumab injection, like many medications, can cause a range of side effects. Some of these side effects are common, while others are less common but potentially more serious. It’s essential to be aware of these potential side effects and to discuss any concerns with your healthcare provider. Common side effects of Bevacizumab injection may include:

• Hypertension (high blood pressure): Bevacizumab can cause an increase in blood pressure, which may require monitoring and management with antihypertensive medications.
• Proteinuria (protein in the urine): Bevacizumab may lead to increased protein levels in the urine, which can indicate kidney damage.
• Bleeding or clotting problems: Bevacizumab can increase the risk of bleeding or clotting disorders, which may manifest as nosebleeds, easy bruising, or blood in the urine or stool.
• GI perforation (gastrointestinal perforation): In rare cases, Bevacizumab may cause a hole to form in the stomach, intestine, or bowel, leading to serious complications.
• Wound healing complications: Bevacizumab may impair the body’s ability to heal wounds, which can be problematic before or after surgery.
• Fatigue: Feeling tired or fatigued is a common side effect of Bevacizumab treatment.
• Loss of appetite: Some patients may experience a decreased appetite while receiving Bevacizumab.
• Headache: Headaches are a relatively common side effect of Bevacizumab treatment.
• Nausea and vomiting: These gastrointestinal symptoms may occur during Bevacizumab treatment.
• Diarrhea: Bevacizumab can cause diarrhea in some patients.

Less common but more serious side effects of Bevacizumab injection may include:

• Allergic reactions: Anaphylaxis or severe allergic reactions are rare but possible with Bevacizumab treatment.
• Heart problems: Bevacizumab may increase the risk of heart attack, heart failure, or other cardiovascular complications.
• Thromboembolic events: Bevacizumab treatment may increase the risk of blood clots, which can lead to serious conditions such as stroke or pulmonary embolism.
• Hypertensive crisis: In rare cases, Bevacizumab can cause a sudden and severe increase in blood pressure, known as a hypertensive crisis.

It’s important to report any side effects experienced during Bevacizumab treatment to your healthcare provider promptly. Your healthcare team can provide guidance on managing side effects and adjusting your treatment plan if necessary.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Bevacizumab Injection:

Storage:

• Bevacizumab Injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
• Do not freeze Bevacizumab. Freezing may damage the medication and make it ineffective.
• Keep Bevacizumab Injection in its original packaging or container until ready to use to protect it from light.
• Do not shake the vial vigorously. Gently invert the vial to mix the solution if necessary.

Disposal:

• Unused or expired Bevacizumab Injection should be disposed of properly according to local regulations or guidelines.
• Do not dispose of Bevacizumab in household trash or flush it down the toilet unless instructed to do so by a healthcare professional or pharmacist.
• Contact your healthcare provider, clinic, or pharmacy for instructions on how to safely dispose of Bevacizumab Injection.

In case of emergency/overdose

• Seek immediate medical attention by calling emergency services or visiting the nearest emergency room.
• Provide as much information as possible about the medication, including the dosage and time of administration.
• Be prepared to provide information about the patient’s medical history, current medications, and any symptoms or adverse reactions experienced.

What other information should I know?

• Bevacizumab may interact with other medications, supplements, or herbal products. Inform your healthcare provider about all medications you are taking before starting Bevacizumab treatment.
• Bevacizumab may weaken the immune system, increasing the risk of infections. Avoid close contact with people who are sick, practice good hygiene, and follow your healthcare provider’s recommendations for infection prevention.
• Regular medical monitoring, including blood tests, imaging studies, and physical examinations, may be necessary during Bevacizumab treatment to assess its effectiveness and monitor for potential side effects.
• Notify your healthcare provider if you experience any new or worsening symptoms during Bevacizumab treatment, including signs of allergic reactions, bleeding, heart problems, or other serious adverse effects.
• Bevacizumab is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Do not share Bevacizumab with others or use it for conditions for which it has not been prescribed.

Always follow your healthcare provider’s instructions and recommendations regarding the use, storage, and disposal of Bevacizumab Injection, and contact them if you have any questions or concerns.