WARNING

Basiliximab injection is a medication used to prevent organ rejection after kidney transplantation. Like all medications, it carries some risks. Common side effects may include headache, diarrhea, nausea, and fever. More serious risks include allergic reactions, infections, and decreased kidney function. It’s essential for patients to discuss these risks with their healthcare provider and follow their guidance closely during treatment.

Why is this medication prescribed?

Basiliximab injection is prescribed to prevent rejection of transplanted kidneys in patients who have undergone kidney transplantation. It is typically used in combination with other immunosuppressive medications to help prevent the body’s immune system from attacking and rejecting the transplanted organ.

How should this medicine be used?

The medication is administered intravenously (into a vein) usually as a single dose within hours before or after the kidney transplant surgery, and then a second dose is given about 4 days later. The dosage and timing may vary based on individual patient factors and the specific protocol recommended by the healthcare provider. It’s crucial for patients to follow their healthcare provider’s instructions carefully and attend all scheduled appointments for monitoring and adjustment of their treatment regimen.

Other uses for this medicine

Basiliximab injection is primarily used for preventing organ rejection after kidney transplantation and is not typically prescribed for other purposes. It works by targeting certain cells in the immune system to help prevent them from attacking the transplanted kidney.

What special precautions should I follow?

Special precautions should be observed when using Basiliximab injection:

• Allergic reactions: Patients should inform their healthcare provider of any known allergies, especially to medications or proteins. Allergic reactions to basiliximab can occur and may require immediate medical attention.
• Infections: Basiliximab suppresses the immune system, which can increase the risk of infections. Patients should be vigilant for signs of infection and report any symptoms to their healthcare provider promptly.
• Vaccinations: Live vaccines should be avoided while receiving basiliximab or within a certain period after treatment. Patients should consult their healthcare provider for advice on vaccination schedules.
• Monitoring: Patients will require regular monitoring of their kidney function, blood pressure, and overall health while receiving basiliximab treatment. Close communication with healthcare providers is essential to ensure proper management and adjustment of the treatment plan as needed.
• Pregnancy and breastfeeding: The safety of basiliximab during pregnancy and breastfeeding has not been established. Patients should inform their healthcare provider if they are pregnant, planning to become pregnant, or breastfeeding before starting treatment.
• Drug interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as basiliximab may interact with certain drugs.

It’s important for patients to discuss any concerns or questions about basiliximab with their healthcare provider to ensure safe and effective treatment.

What special dietary instructions should I follow?

Special dietary instructions for Basiliximab Injection are generally not required. However, it’s essential to maintain a healthy and balanced diet to support overall health and aid in the recovery process post-transplantation. Follow any dietary recommendations provided by your healthcare provider or transplant team.

What should I do if I forget a dose?

If you forget a dose of Basiliximab Injection, contact your healthcare provider or transplant team immediately for guidance. It’s important to follow the prescribed dosing schedule closely to ensure the effectiveness of the medication in preventing organ rejection. Missing a dose may increase the risk of rejection, so it’s crucial to address any missed doses promptly.

What side effects can this medication cause?

Basiliximab injection, like any medication, can cause side effects, although not everyone experiences them. Common side effects may include:

• Headache: Mild to moderate headaches are relatively common.
• Nausea and vomiting: Some patients may experience gastrointestinal discomfort such as nausea or vomiting.
• Fever: Low-grade fever may occur, especially in the days following administration.
• Diarrhea: Digestive disturbances like diarrhea may occur.
• Pain at injection site: Discomfort or pain at the site of injection is possible.
• High blood pressure: Some patients may experience elevated blood pressure as a side effect.

Less common but more serious side effects may include:

• Allergic reactions: This can manifest as rash, itching, swelling, dizziness, or difficulty breathing. Severe allergic reactions require immediate medical attention.
• Infections: Since basiliximab suppresses the immune system, it can increase the risk of infections. Patients should monitor for signs of infection such as fever, chills, cough, or sore throat.
• Decreased kidney function: In some cases, basiliximab may cause a decrease in kidney function, although this is usually temporary.

It’s important for patients to report any side effects to their healthcare provider promptly. They can provide guidance on managing side effects and may adjust the treatment plan if necessary to minimize discomfort or risk.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Basiliximab Injection:

• Storage: Store Basiliximab Injection in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the medication in its original carton to protect it from light. Do not shake the vial.
• Disposal: Unused or expired Basiliximab Injection should be disposed of properly according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not dispose of medications in wastewater or household waste unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose of Basiliximab Injection, seek immediate medical attention or contact a poison control center. Overdose symptoms may include severe allergic reactions, severe infections, or other serious side effects. It’s essential to have emergency medical assistance available in case of such situations.

What other information should I know?

• Follow-up: Attend all scheduled follow-up appointments with your healthcare provider or transplant team. Regular monitoring of kidney function, blood pressure, and overall health is essential during treatment with Basiliximab Injection.
• Medical Alert: Inform all healthcare providers involved in your care, including dentists and specialists, that you are receiving Basiliximab Injection. This is important for proper coordination of care and management of any potential interactions or complications.
• Avoiding Illness: Since Basiliximab suppresses the immune system, it’s important to take precautions to avoid illness and infection. Practice good hygiene, wash hands frequently, avoid close contact with sick individuals, and follow any additional recommendations provided by your healthcare provider.
• Medication Compliance: It’s crucial to adhere to the prescribed dosage and schedule of Basiliximab Injection as directed by your healthcare provider. Skipping doses or altering the treatment regimen without medical supervision can increase the risk of organ rejection or other complications.

By following these guidelines and staying informed about Basiliximab Injection, you can ensure safe and effective treatment after kidney transplantation.