WARNING

Zyprexa Zydis (olanzapine) is an antipsychotic medication that can be effective for treating certain mental health conditions, but like any medication, it comes with potential risks. It’s important to note that the decision to use Zyprexa Zydis should be made in consultation with a healthcare professional, weighing the potential benefits against the risks. Some of the risks associated with taking Zyprexa Zydis include:

• Weight Gain: Zyprexa is known to be associated with significant weight gain in some individuals. This can contribute to other health issues, such as metabolic syndrome and diabetes.
• Metabolic Effects: Zyprexa Zydis can lead to metabolic changes, including elevated blood sugar levels and increased cholesterol levels. Regular monitoring of these parameters is often recommended.
• Orthostatic Hypotension: Some people may experience a drop in blood pressure upon standing, leading to dizziness or fainting.
• Extrapyramidal Symptoms: Zyprexa Zydis may cause extrapyramidal symptoms, including tremors, stiffness, and restlessness.
• Sedation: Drowsiness and sedation are common side effects of Zyprexa, which can affect daily activities requiring alertness.
• Increased Risk of Stroke in Elderly Patients with Dementia: Elderly patients with dementia-related psychosis treated with antipsychotic medications like Zyprexa Zydis are at an increased risk of stroke and death.
• Neuroleptic Malignant Syndrome (NMS): Though rare, Zyprexa Zydis can potentially cause a serious condition known as neuroleptic malignant syndrome, characterized by fever, muscle rigidity, and altered mental status.
• Tardive Dyskinesia: Prolonged use of antipsychotic medications, including Zyprexa, may lead to tardive dyskinesia—a condition characterized by involuntary movements, especially of the face.
• Increased Mortality in Elderly Patients with Dementia-Related Psychosis: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

It’s crucial for individuals taking Zyprexa Zydis to be closely monitored by their healthcare provider for any potential side effects. The decision to use this medication should be based on a thorough evaluation of the individual’s mental health condition, medical history, and potential risks and benefits. Before starting or discontinuing any medication, it’s important to discuss the plan with a healthcare professional.

Why is this medication prescribed?

Zyprexa Zydis is a brand name for the medication olanzapine, which belongs to a class of drugs called atypical antipsychotics. It is primarily prescribed for the treatment of certain mental/mood conditions, such as schizophrenia and bipolar disorder. Here are some key points about Zyprexa Zydis:

• Schizophrenia: Zyprexa Zydis is used for the treatment of schizophrenia, a mental disorder characterized by disturbances in thinking, emotions, and behavior.
• Bipolar Disorder: It is also used in the treatment of bipolar disorder (manic or mixed episodes), which involves episodes of mania (elevated mood, excessive activity) and depression.

How should this medicine be used?

Zyprexa Zydis is an orally disintegrating tablet (ODT) formulation of the medication olanzapine. Here are general guidelines for the use of Zyprexa Zydis. However, it is important to note that individualized dosing instructions may vary, and patients should always follow the specific guidance provided by their healthcare provider:

• Administration:  Zyprexa Zydis is designed to dissolve quickly in the mouth without the need for water. It should be taken exactly as prescribed by the healthcare provider. The tablet should be handled with dry hands and placed on the tongue, where it will disintegrate within seconds.
• Dosage: The dosage of Zyprexa Zydis is determined by the healthcare provider based on the individual’s condition, response to treatment, and other factors. Patients should never adjust the dosage on their own without consulting their healthcare provider.
• Timing of Administration: Zyprexa Zydis can be taken with or without food. However, patients should follow their healthcare provider’s instructions regarding the timing of administration.
• Consistency: It is important to take Zyprexa Zydis consistently at the same time each day to maintain a steady level of the medication in the body.
• Do Not Crush or Chew: The orally disintegrating tablet should not be crushed, chewed, or broken. It is designed to be taken whole, and the disintegration in the mouth allows for rapid absorption.
• Missed Dose:  If a dose is missed, it should be taken as soon as remembered. However, if it is close to the time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed.
• Follow-up Appointments: Patients taking Zyprexa Zydis should have regular follow-up appointments with their healthcare provider to monitor the effectiveness of the medication and address any concerns or potential side effects.
• Adherence: It is crucial to adhere to the prescribed dosage and schedule. Abruptly stopping the medication without consulting a healthcare provider can lead to withdrawal symptoms or a return of symptoms.
• Side Effects and Reporting: Patients should be aware of potential side effects and report any unusual or severe symptoms to their healthcare provider promptly.

It is important to emphasize that the information provided here is general, and patients should always follow the specific instructions given by their healthcare provider. If there are any questions or concerns about the use of Zyprexa Zydis, patients should consult their healthcare professional for clarification and guidance.

Other uses for this medicine

Zyprexa Zydis, with the active ingredient olanzapine, is primarily prescribed for the treatment of certain mental/mood conditions, such as schizophrenia and bipolar disorder. It is an antipsychotic medication that works by affecting certain chemicals in the brain.

While it’s essential to use medications only for their intended purposes as prescribed by a healthcare professional, Zyprexa may sometimes be used off-label for conditions not specifically approved by regulatory authorities. Off-label use should only occur under the guidance and supervision of a healthcare provider.

What special precautions should I follow?

Special Precautions for Zyprexa Zydis:

• Medical History: Inform your healthcare provider of your complete medical history, including any allergies, liver problems, diabetes, seizures, or cardiovascular conditions.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of Zyprexa Zydis during pregnancy and breastfeeding should be discussed.
• Interactions with Other Medications: Inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are currently taking. Some medications may interact with Zyprexa Zydis.
• Diabetes Risk: Zyprexa Zydis may be associated with an increased risk of high blood sugar and diabetes. Regular monitoring of blood sugar levels is typically recommended, especially in individuals with pre-existing diabetes or those at risk.
• Cardiovascular Effects: Zyprexa Zydis may cause changes in blood pressure and lipid levels. Regular monitoring of cardiovascular health may be necessary.
• Weight Gain: Weight gain is a potential side effect of Zyprexa Zydis. Monitoring weight and making lifestyle adjustments may be recommended.
• Elderly Population: Elderly individuals with dementia-related psychosis treated with antipsychotic drugs like Zyprexa Zydis may be at an increased risk of death. This medication is not approved for the treatment of patients with dementia-related psychosis.
• Seizures: Zyprexa Zydis should be used with caution in individuals with a history of seizures.
• Hypersensitivity Reactions: If you have had a hypersensitivity reaction to olanzapine in the past, inform your healthcare provider.
• Alcohol and CNS Depression: Combining Zyprexa Zydis with alcohol or other central nervous system (CNS) depressants may increase the risk of sedation and impairment.

It’s crucial to follow your healthcare provider’s advice, attend regular check-ups, and communicate any concerns or side effects promptly. This information is not exhaustive, and individualized guidance from a healthcare professional is essential for safe and effective use.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Zyprexa Zydis. However, individuals taking this medication should maintain a healthy and balanced diet. The medication may be associated with weight gain, so monitoring food intake and engaging in regular physical activity can be important.

What should I do if I forget a dose?

If you forget to take a dose of Zyprexa Zydis:

• If you forget to take a dose of Zyprexa Zydis, take it as soon as you remember.
• However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double up on doses to make up for a missed one.
• If you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zyprexa Zydis (olanzapine) is an antipsychotic medication that is used to treat certain mental/mood conditions, such as schizophrenia and bipolar disorder. Like all medications, Zyprexa Zydis can cause side effects, and it’s important to be aware of them. Keep in mind that not everyone will experience these side effects, and some people may experience effects that are not listed. If you are prescribed Zyprexa Zydis, your healthcare provider will closely monitor you for any side effects. Common side effects include:

• Drowsiness: Zyprexa Zydis may cause drowsiness. Avoid activities that require alertness (such as driving) until you know how the medication affects you.
• Weight Gain: Significant weight gain can occur in some individuals taking Zyprexa. Maintaining a healthy diet and exercise routine is important. If you notice significant weight gain, discuss it with your healthcare provider.
• Increased Appetite: Some people may experience an increase in appetite while taking Zyprexa, contributing to potential weight gain.
• Dry Mouth: Zyprexa may cause dry mouth. Staying hydrated and using sugarless gum or candy may help alleviate this symptom.
• Constipation: Constipation is a common side effect of Zyprexa. Eating a high-fiber diet, drinking plenty of water, and staying physically active can help prevent or manage constipation.
• Dizziness: Zyprexa Zydis may cause dizziness, especially when standing up from a sitting or lying position. Take care when moving to avoid falls.
• Increased Blood Sugar Levels: Olanzapine can affect blood sugar levels. Individuals with diabetes may need to monitor their blood sugar more closely while taking this medication.
• Increased Cholesterol Levels: Zyprexa Zydis can lead to an increase in cholesterol levels. Regular monitoring of cholesterol levels is typically recommended.
• Restlessness or Tremors: Some individuals may experience restlessness or tremors, which should be reported to a healthcare provider.
• Sleep Disturbances: Changes in sleep patterns, including insomnia, may occur.

It’s important to contact your healthcare provider if you experience any side effects, especially if they are severe or persistent. Additionally, if you experience any serious side effects, such as difficulty breathing, chest pain, severe dizziness, or unusual muscle movements, seek immediate medical attention.

This is not an exhaustive list of side effects, and individual responses to medications can vary. Always consult with your healthcare provider for personalized information regarding your specific situation.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zyprexa Zydis:

• Storage:
  • Store Zyprexa Zydis at room temperature between 20-25°C (68-77°F).
  • Keep the medication in its original packaging to protect it from light and moisture.
• Disposal:
  • Follow local guidelines or regulations for the proper disposal of medications.
  • Do not flush Zyprexa Zydis down the toilet unless instructed to do so.
  • If unsure about how to dispose of the medication, consult with a pharmacist or healthcare provider.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention immediately. Symptoms of overdose may include:

• Severe drowsiness or sedation
• Agitation or restlessness
• Rapid or irregular heartbeat
• Uncontrolled movements or seizures
• Loss of consciousness

What other information should I know?

• Medication Adherence: Take Zyprexa Zydis exactly as prescribed by your healthcare provider. Do not change the dose without consulting them.
• Regular Follow-ups: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and check for any potential side effects.
• Avoid Alcohol: Limit or avoid alcohol while taking Zyprexa Zydis, as alcohol can interact with the medication.
• Inform Healthcare Providers: Inform any healthcare provider treating you about all the medications you are taking, including prescription and over-the-counter medications, as well as any supplements.

Always follow the advice and instructions provided by your healthcare provider. If you have specific questions or concerns about Zyprexa Zydis, consult with your healthcare professional for personalized guidance.